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How to get fromDes Moines to Lexingtonby plane, car or bus

Find Transport to Lexington

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There are 5 ways to get from Des Moines to Lexington by plane, car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Louisville International Airport, drive

    best
    1. Fly from Des Moines (DSM) to Louisville International Airport (SDF)plane plane DSM - SDF
    2. Drive from Louisville-Airport-SDF to Lexingtoncar car
    5h 57m
    $192–992

  2. Drive 648.6 mi

    cheapest
    1. Drive from Des Moines to Lexingtoncar car 648.6 mi
    11h 13m
    $119–171

  3. Bus, drive

    1. Take the bus from Des Moines to Kansas Citybus bus
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    4. Take the bus from Evansville, IN to Corydon, INbus bus
    5. Drive from Middletown Station @ Target to Lexingtoncar car
    19h 23m
    $183–334

  4. Fly to Covington, drive

    1. Fly from Des Moines (DSM) to Covington (CVG)plane plane DSM - CVG
    2. Drive from Covington (CVG) to Lexingtoncar car
    5h 25m
    $243–1,343

  5. Fly to Blue Grass Airport

    1. Fly from Des Moines (DSM) to Blue Grass Airport (LEX)plane plane DSM - LEX
    6h 31m
    $130–673

Des Moines (DSM) to Louisville International Airport (SDF) flights

Calendar85Weekly Planes
Duration5h 47mAverage Duration
Ticket$163Cheapest Price
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Questions & Answers

What companies run services between Des Moines, IA, USA and Lexington, KY, USA?

United Airlines, American Airlines, and Delta fly from Des Moines (DSM) to Blue Grass Airport (LEX) every 2 hours.

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