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How to get fromDes Moines to Ithacaby plane, bus, train, bus (Greyhound, Flixbus) or car

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There are 12 ways to get from Des Moines to Ithaca by plane, bus, train, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Syracuse Hancock International Airport, bus

    best
    1. Fly from Des Moines (DSM) to Syracuse Hancock International Airport (SYR)planeDSM - SYR
    2. Take the bus from Syracuse Airport, NY to Ithaca, NYbus
    7h 28m
    $228–1,076

  2. Bus via Cleveland

    cheapest
    1. Take the bus from Des Moines to Chicagobus
    2. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus
    3. Take the bus from Cleveland, OH to Buffalo, NYbus
    4. Take the bus from Buffalo to Ithacabus
    23h 15m
    $146–338

  3. Bus, train

    1. Take the bus from Des Moines to Chicagobus
    2. Take the train from Chicago Union Station to Syracuse Regional Transportation Centertrain
    3. Take the bus from Syracuse Bus Station to Ithacabus
    22h 21m
    $182–392

  4. Drive 974 mi

    1. Drive from Des Moines to Ithacacar974 mi
    16h 47m
    $178–257

  5. Fly to Rochester, bus

    1. Fly from Des Moines (DSM) to Rochester (ROC)planeDSM - ROC
    2. Take the bus from Rochester, NY to Ithaca, NYbus
    7h 56m
    $188–881

  6. Fly to Greater Binghamton Airport, bus

    1. Fly from Des Moines (DSM) to Greater Binghamton Airport (BGM)planeDSM - BGM
    2. Take the bus from Binghamton to Ithacabus
    8h 59m
    $186–751

  7. Fly to Elmira/Corning Regional Airport, bus

    1. Fly from Des Moines (DSM) to Elmira/Corning Regional Airport (ELM)planeDSM - ELM
    2. Take the bus from Transit Center - PO Side to Tompkins County Librarybus
    7h 46m

  8. Fly to Wilkes-Barre/Scranton International Airport, bus

    1. Fly from Des Moines (DSM) to Wilkes-Barre/Scranton International Airport (AVP)planeDSM - AVP
    2. Take the bus from Scranton, Pa to Ithacabus
    8h 26m
    $195–781

  9. Fly to Laguardia Airport, bus

    1. Fly from Des Moines (DSM) to Laguardia Airport (LGA)planeDSM - LGA
    2. Take the bus from New York, NY to Ithaca, NYbus
    9h
    $158–751

  10. Bus, train via Des Moines

    1. Take the bus from Des Moines to Chicagobus
    2. Take the train from Chicago Union Station to Syracuse Regional Transportation Centertrain
    3. Take the bus from Syracuse Bus Station to Ithacabus
    23h 26m
    $170–403

  11. Bus, train via Galesburg

    1. Take the bus from Des Moines to Burlingtonbus
    2. Take the bus from Burlington to Galesburgbus
    3. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain
    4. Take the train from Chicago Union Station to Syracuse Regional Transportation Centertrain
    5. Take the bus from Syracuse Bus Station to Ithacabus
    24h 57m
    $200–446

  12. Bus

    1. Take the bus from Des Moines to Chicago Bus Stationbus
    2. Take the bus from Chicago Bus Station to Detroit Bus Stationbus
    3. Take the bus from Detroit Bus Station to Torontobus
    4. Take the bus from Toronto to Ithacabus
    30h 55m
    $160–317

Des Moines to Ithaca by bus, foot, and train

Calendar7Weekly Services
Duration22h 21mAverage Duration
Ticket$182Cheapest Price
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Questions & Answers

What companies run services between Des Moines, IA, USA and Ithaca, NY, USA?

You can take a bus from Des Moines to Ithaca via Chicago Bus Station, Cleveland Bus Station, Cleveland, OH, Buffalo, NY, and Buffalo in around 23h 15m.

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