There are 5 ways to get from Des Moines to East Saint Louis by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  3 h 3 min

  1. Fly from Des Moines (DSM) to St. Louis (STL) DSM - STL

$195 - $905

Cheapest option

Bus Greyhound USA  •  8 h 26 min

  1. Take the bus from Des Moines, IA to Kansas City, MO 803 / ...
  2. Take the bus from Kansas City, Mo to St Louis, Mo 1682 / ...

$75 - $130

3 alternative options

Bus, train  •  10 h 26 min

  1. Take the bus from Des Moines, IA to Kansas City, MO 803 / ...
  2. Take the train from Kansas City Amtrak to St. Louis Gateway Station Missouri River Runner

$98 - $192

Bus Burlington Trailways  •  17 h

  1. Take the bus from Des Moines, IA to Burlington, IA 1491,1401 / ...
  2. Take the bus from Burlington, IA to St Louis, MO 1490

$85 - $155

Drive  •  6 h 29 min

  1. Drive from Des Moines to East Saint Louis 353 miles

$30 - $50

Questions & Answers

The cheapest way to get from Des Moines to East Saint Louis is to drive which costs $30 - $50 and takes 6 h 29 min.

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The quickest way to get from Des Moines to East Saint Louis is to fly which costs $190 - $950 and takes 3 h 3 min.

More details

The distance between Des Moines and East Saint Louis is 277 miles. The road distance is 353 miles.

Get driving directions

The best way to get from Des Moines to East Saint Louis without a car is to bus which takes 8 h 26 min and costs $70 - $130.

More details

It takes approximately 3 h 3 min to get from Des Moines to East Saint Louis, including transfers.

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The best way to get from Des Moines to East Saint Louis is to fly which takes 3 h 3 min and costs $190 - $950. Alternatively, you can bus, which costs $70 - $130 and takes 8 h 26 min.

Mode details

The quickest flight from Des Moines Airport to St. Louis Airport is the direct flight which takes 55 min.

Search flights

Yes, the driving distance between Des Moines to East Saint Louis is 353 miles. It takes approximately 6 h 29 min to drive from Des Moines to East Saint Louis.

Get driving directions

Southwest Airlines offers flights from Des Moines Airport to St. Louis Airport.

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There are 158+ hotels available in East Saint Louis. Prices start at $74 USD per night.

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The best way to get from Des Moines to Des Moines Airport is to line 8 bus which takes 11 min and costs $2.

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Map of how to get from Des Moines to East Saint Louis.
Launch map view
  • Distance: 276.6 miles
  • Duration: 3 h 3 min

What companies run services between Des Moines, IA, USA and East Saint Louis, IL, USA?

Southwest Airlines flies from Des Moines to East Saint Louis twice daily. Alternatively, you can take a bus from Des Moines to East Saint Louis via Kansas City, MO, Kansas City, Mo, St Louis, Mo, 20Th Street @ Cass Sb, Civic Center Transit Center, and CIVIC CENTER station in around 8 h 26 min.

Airlines
Southwest Airlines
Website
southwest.com
Flights from Des Moines to St. Louis
Ave. Duration
58 min
When
Every day
Estimated price
$190 - $900
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Kansas City Amtrak to St. Louis Gateway Station
Ave. Duration
5 h 40 min
Frequency
Twice daily
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$85 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Bus operators
Jefferson Lines
Phone
800-451-5333
Email
info@jeffersonlines.com
Website
jeffersonlines.com
Bus from Des Moines, IA to Kansas City, MO
Ave. Duration
3 h 10 min
Frequency
Hourly
Estimated price
$40 - $55
Book at
jeffersonlines.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Kansas City, Mo to St Louis, Mo
Ave. Duration
4 h
Frequency
Hourly
Estimated price
$29 - $70
Website
greyhound.com
Economy
$29 - $45
Flexible
$50 - $70
Burlington Trailways
Website
burlingtontrailways.com
Bus from Des Moines, IA to Burlington, IA
Ave. Duration
10 h 50 min
Frequency
Once daily
Estimated price
$35 - $55
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Bus from Burlington, IA to St Louis, MO
Ave. Duration
4 h 55 min
Frequency
Once daily
Estimated price
$45 - $100
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com

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