There are 5 ways to get from Des Moines to East Saint Louis by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  3 h 4 min

  1. Fly from Des Moines (DSM) to St. Louis (STL) DSM - STL

$194 - $904

Cheapest option

Bus Greyhound USA  •  8 h 15 min

  1. Take the bus from Des Moines, IA to Kansas City, MO 803 / ...
  2. Take the bus from Kansas City, Mo to St Louis, Mo 1682 / ...

$74 - $129

3 alternative options

Bus, train  •  10 h 28 min

  1. Take the bus from Des Moines, IA to Kansas City, MO 803 / ...
  2. Take the train from Kansas City Amtrak to St. Louis Gateway Station Amtrak Missouri River Runner

$97 - $191

Bus Burlington Trailways  •  17 h

  1. Take the bus from Des Moines, IA to Burlington, IA 1491,1401 / ...
  2. Take the bus from Burlington, IA to St Louis, MO 1490

$84 - $154

Drive  •  6 h 29 min

  1. Drive from Des Moines to East Saint Louis 353 miles

$30 - $50

What companies run services between Des Moines, IA, USA and East Saint Louis, IL, USA?

Southwest Airlines flies from Des Moines to East Saint Louis twice daily. Alternatively, you can take a bus from Des Moines to East Saint Louis via Kansas City, MO, Kansas City, Mo, St Louis, Mo, 20Th Street @ Cass Sb, Civic Center Transit Center, and CIVIC CENTER station in around 8 h 15 min.

Airlines
Southwest Airlines
Website
southwest.com
Flights from Des Moines to St. Louis
Ave. Duration
58 min
When
Every day
Estimated price
$190 - $900
Train operators
Amtrak
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Kansas City Amtrak to St. Louis Gateway Station Amtrak
Ave. Duration
5 h 40 min
Frequency
Twice daily
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$85 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Bus operators
Jefferson Lines
Phone
800-451-5333
Email
info@jeffersonlines.com
Website
jeffersonlines.com
Bus from Des Moines, IA to Kansas City, MO
Ave. Duration
3 h 10 min
Frequency
Hourly
Estimated price
$40 - $55
Schedules at
jeffersonlines.com
Greyhound USA
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Kansas City, Mo to St Louis, Mo
Ave. Duration
4 h
Frequency
Hourly
Estimated price
$29 - $70
Website
greyhound.com
Economy
$29 - $45
Flexible
$50 - $70
Burlington Trailways
Website
burlingtontrailways.com
Bus from Des Moines, IA to Burlington, IA
Ave. Duration
10 h 50 min
Frequency
Once daily
Estimated price
$35 - $55
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Bus from Burlington, IA to St Louis, MO
Ave. Duration
4 h 55 min
Frequency
Once daily
Estimated price
$45 - $100
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Questions & Answers

The distance between Des Moines and East Saint Louis is 443 km. The road distance is 565 km.

The cheapest way to get from Des Moines to East Saint Louis is to drive which costs $30 - $50 and takes 6 h 29 min.

The quickest way to get from Des Moines to East Saint Louis is to fly which takes 3 h 4 min and costs $190 - $950.

It takes approximately 3 h 4 min to get from Des Moines to East Saint Louis, including transfers.