There are 6 ways to get from Des Moines to Cincinnati by plane, bus (Greyhound), bus, train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Covington
best- Fly from Des Moines (DSM) to Covington (CVG)plane DSM - CVG
4h 32m$131–675Bus
cheapest- Take the bus from Des Moines to Indianapolis Union Stationbus Greyhound US0157S
- Take the bus from Indianapolis to Cincinnatibus Bsb 15 / ...
14h 35m$96–202Bus, train
- Take the bus from Des Moines to Galesburgbus
- Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Indianapolistrain
- Take the bus from Indianapolis to Cincinnatibus
19h 29m$236–444Drive 572.5 mi
- Drive from Des Moines to Cincinnaticar 572.5 mi
9h 44m$105–151Fly to Louisville International Airport, drive
- Fly from Des Moines (DSM) to Louisville International Airport (SDF)plane DSM - SDF
- Drive from Louisville-Airport-SDF to Cincinnaticar
5h 34m$148–701Fly to Blue Grass Airport, drive
- Fly from Des Moines (DSM) to Blue Grass Airport (LEX)plane DSM - LEX
- Drive from Lexington-Airport-LEX to Cincinnaticar
6h$99–426
Des Moines to Cincinnati by bus
Comparing Your Travel Options
The cheapest way to get from Des Moines to Cincinnati is to drive which costs $100 - $160 and takes 9h 44m.
The fastest way to get from Des Moines to Cincinnati is to fly which takes 4h 32m and costs $130 - $700.
No, there is no direct bus from Des Moines to Cincinnati. However, there are services departing from Des Moines and arriving at Cincinnati via Indianapolis and Cincinnati. The journey, including transfers, takes approximately 14h 35m.
The distance between Des Moines and Cincinnati is 527 miles. The road distance is 575.8 miles.
The best way to get from Des Moines to Cincinnati without a car is to bus which takes 14h 35m and costs $95 - $210.
It takes approximately 4h 32m to get from Des Moines to Cincinnati, including transfers.
Des Moines to Cincinnati bus services, operated by Greyhound USA, depart from Des Moines station.
The best way to get from Des Moines to Cincinnati is to fly which takes 4h 32m and costs $130 - $700. Alternatively, you can bus, which costs $95 - $210 and takes 14h 35m.
Des Moines to Cincinnati bus services, operated by Greyhound USA, arrive at Indianapolis Union Station.
Cincinnati is 1h ahead of Des Moines. It is currently 5:33 AM in Des Moines and 6:33 AM in Cincinnati.
What companies run services between Des Moines, IA, USA and Cincinnati, OH, USA?
Southwest Airlines, Delta, and two other airlines fly from Des Moines (DSM) to Covington (CVG) hourly. Alternatively, you can take a bus from Des Moines to Cincinnati via Indianapolis and Cincinnati in around 14h 35m.
- Website
- delta.com
Flights from Des Moines to Covington via Detroit
- Ave. Duration
- 4h 51m
- When
- Every day
- Estimated price
- $130–700
Flights from Des Moines to Covington via Minneapolis
- Ave. Duration
- 4h 9m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $130–750
Flights from Des Moines to Covington via Atlanta
- Ave. Duration
- 5h 20m
- When
- Every day
- Estimated price
- $160–800
Flights from Des Moines to Louisville International Airport via Atlanta
- Ave. Duration
- 5h 4m
- When
- Every day
- Estimated price
- $160–850
Flights from Des Moines to Louisville International Airport via Detroit
- Ave. Duration
- 6h 48m
- When
- Every day
- Estimated price
- $140–750
Flights from Des Moines to Louisville International Airport via Minneapolis
- Ave. Duration
- 6h 3m
- When
- Every day
- Estimated price
- $140–750
Flights from Des Moines to Blue Grass Airport via Atlanta
- Ave. Duration
- 5h 4m
- When
- Every day
- Estimated price
- $90–460
Flights from Des Moines to Blue Grass Airport via Detroit
- Ave. Duration
- 6h 41m
- When
- Thursday and Saturday
- Estimated price
- $80–420
- Website
- united.com
Flights from Des Moines to Covington via Chicago O'Hare
- Ave. Duration
- 4h 33m
- When
- Every day
- Estimated price
- $110–650
Flights from Des Moines to Louisville International Airport via Chicago O'Hare
- Ave. Duration
- 4h 34m
- When
- Every day
- Estimated price
- $110–650
Flights from Des Moines to Blue Grass Airport via Chicago O'Hare
- Ave. Duration
- 4h 37m
- When
- Every day
- Estimated price
- $65–380
- Website
- aa.com
Flights from Des Moines to Covington via Chicago O'Hare
- Ave. Duration
- 4h 18m
- When
- Every day
- Estimated price
- $110–650
Flights from Des Moines to Covington via Charlotte
- Ave. Duration
- 6h 11m
- When
- Every day
- Estimated price
- $170–850
Flights from Des Moines to Louisville International Airport via Charlotte
- Ave. Duration
- 5h 54m
- When
- Every day
- Estimated price
- $170–850
Flights from Des Moines to Louisville International Airport via Chicago O'Hare
- Ave. Duration
- 6h 36m
- When
- Every day
- Estimated price
- $110–650
Flights from Des Moines to Blue Grass Airport via Charlotte
- Ave. Duration
- 4h 52m
- When
- Thursday
- Estimated price
- $95–470
Flights from Des Moines to Blue Grass Airport via Philadelphia
- Ave. Duration
- 6h 10m
- When
- Every day
- Estimated price
- $120–550
Flights from Des Moines to Blue Grass Airport via Dallas/Ft.Worth
- Ave. Duration
- 7h 34m
- When
- Every day
- Estimated price
- $110–550
Flights from Des Moines to Blue Grass Airport via Chicago O'Hare
- Ave. Duration
- 8h 33m
- When
- Every day
- Estimated price
- $65–380
- Website
- southwest.com
Flights from Des Moines to Covington via Chicago Midway
- Ave. Duration
- 3h 52m
- When
- Every day
- Estimated price
- $110–650
Flights from Des Moines to Covington via Nashville
- Ave. Duration
- 3h 55m
- When
- Monday to Friday
- Estimated price
- $130–700
Flights from Des Moines to Louisville International Airport via Chicago Midway
- Ave. Duration
- 4h 1m
- When
- Tuesday to Saturday
- Estimated price
- $110–650
Flights from Des Moines to Louisville International Airport via Nashville
- Ave. Duration
- 5h 15m
- When
- Monday, Thursday, and Friday
- Estimated price
- $120–700
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Galesburg Amtrak Station to Chicago Union Station
- Ave. Duration
- 2h 55m
- Frequency
- 3 times a day
- Estimated price
- $85–140
- Website
- Amtrak
Train from Chicago Union Station to Indianapolis
- Ave. Duration
- 4h 54m
- Frequency
- 3 times a week
- Estimated price
- $100–170
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- Greyhound
Bus from Des Moines to Indianapolis Union Station
- Ave. Duration
- 9h 25m
- Frequency
- Once daily
- Estimated price
- $80–130
- Website
- Greyhound
Bus from Des Moines to Galesburg
- Ave. Duration
- 4h 30m
- Frequency
- Once daily
- Estimated price
- $35–55
- Website
- Greyhound
- Phone
- +1 888-378-3823
- info@baronsbus.com
- Website
- Barons Bus
Bus from Indianapolis to Cincinnati
- Ave. Duration
- 2h 55m
- Frequency
- Twice daily
- Estimated price
- $13–50
- Website
- Barons Bus
Bus from Indianapolis to Cincinnati
- Ave. Duration
- 2h 55m
- Frequency
- Twice daily
- Estimated price
- $13–50
- Website
- Barons Bus
Want to know more about travelling around United States
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Booking & Getting There
Yes, the driving distance between Des Moines to Cincinnati is 576 miles. It takes approximately 9h 44m to drive from Des Moines to Cincinnati.
Book your Des Moines to Cincinnati bus tickets online with Omio.
There are 598+ hotels available in Cincinnati.












