There are 5 ways to get from Des Moines to Chicago Loop by plane, bus (Greyhound), car, subway, bus, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Chicago O'Hare International Airport
best- Fly from Des Moines (DSM) to Chicago O'Hare International Airport (ORD)plane DSM - ORD
2h 29m$70–386Bus (Greyhound)
cheapest- Take the bus from Des Moines to Chicago Bus Stationbus Greyhound US0123S / ...
7h 19m$54–101Drive 330.9 mi
- Drive from Des Moines to Chicago Loopcar 330.9 mi
5h 34m$61–88Fly to Chicago Midway International Airport, subway
- Fly from Des Moines (DSM) to Chicago Midway International Airport (MDW)plane DSM - MDW
- Take the subway from Midway to Washington/Wellssubway
2h 17m$95–516Bus, train
- Take the bus from Des Moines to Galesburgbus Greyhound US0157S
- Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain Carl Sandburg / ...
8h 40m$76–161
Des Moines to Chicago Loop by bus (Greyhound)
Questions & Answers
The cheapest way to get from Des Moines to Chicago Loop is to bus which costs $50 - $110 and takes 7h 19m.
The fastest way to get from Des Moines to Chicago Loop is to fly and subway which takes 2h 17m and costs $95 - $550.
No, there is no direct bus from Des Moines to Chicago Loop. However, there are services departing from Des Moines and arriving at Washington & Lasalle via Jefferson & Harrison. The journey, including transfers, takes approximately 7h 19m.
The distance between Des Moines and Chicago Loop is 324 miles. The road distance is 332.9 miles.
The best way to get from Des Moines to Chicago Loop without a car is to bus which takes 7h 19m and costs $50 - $110.
It takes approximately 2h 29m to get from Des Moines to Chicago Loop, including transfers.
Des Moines to Chicago Loop bus services, operated by Greyhound USA, depart from Des Moines station.
The best way to get from Des Moines to Chicago Loop is to fly which takes 2h 29m and costs $70 - $390. Alternatively, you can bus, which costs $50 - $110 and takes 7h 19m.
Des Moines to Chicago Loop bus services, operated by Greyhound USA, arrive at Chicago Bus Station.
Yes, the driving distance between Des Moines to Chicago Loop is 333 miles. It takes approximately 5h 34m to drive from Des Moines to Chicago Loop.
What companies run services between Des Moines, IA, USA and Chicago Loop, IL, USA?
American Airlines and United Airlines fly from Des Moines (DSM) to Chicago O'Hare International Airport (ORD) every 2 hours. Alternatively, Greyhound USA operates a bus from Des Moines to Chicago Bus Station 3 times a day. Tickets cost $50–100 and the journey takes 7h 5m.
- Website
- united.com
Flights from Des Moines to Chicago O'Hare International Airport
- Ave. Duration
- 1h 38m
- When
- Every day
- Estimated price
- $50–360
- Website
- aa.com
Flights from Des Moines to Chicago O'Hare International Airport
- Ave. Duration
- 1h 44m
- When
- Every day
- Estimated price
- $50–360
- Website
- southwest.com
Flights from Des Moines to Chicago Midway International Airport
- Ave. Duration
- 1h 21m
- When
- Every day
- Estimated price
- $75–490
- Phone
- +1 888-968-7282
- Website
- transitchicago.com
Subway from Midway to Washington/Wells
- Ave. Duration
- 28 min
- Frequency
- Every 15 minutes
- Estimated price
- $2–5
- Website
- https://www.transitchicago.com
- Schedules at
- https://www.transitchicago.com/schedules/
- Adult
- $2–5
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Galesburg Amtrak Station to Chicago Union Station
- Ave. Duration
- 2h 55m
- Frequency
- 3 times a day
- Estimated price
- $45–100
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Des Moines to Chicago Bus Station
- Ave. Duration
- 7h 5m
- Frequency
- 3 times a day
- Estimated price
- $50–100
- Website
- https://www.greyhound.com/
Bus from Des Moines to Galesburg
- Ave. Duration
- 4h 45m
- Frequency
- Once daily
- Estimated price
- $30–65
- Website
- https://www.greyhound.com/
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide
More Questions & Answers
There are 1418+ hotels available in Chicago Loop.













