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How to get fromDes Moines to Chicago Loopby plane, bus, car, subway or bus (Greyhound)

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There are 6 ways to get from Des Moines to Chicago Loop by plane, bus, car, subway, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Chicago O'Hare International Airport

    best
    1. Fly from Des Moines (DSM) to Chicago O'Hare International Airport (ORD)plane plane DSM - ORD
    2h 30m
    $85–446
  2. Bus via Des Moines #2

    cheapest
    1. Take the bus from Des Moines to Chicagobus bus Des Moines
    7h 29m
    $59–157
  3. Bus

    1. Take the bus from Des Moines to Chicagobus bus Omaha
    6h 10m
    $65–143
  4. Drive 330.9 mi

    1. Drive from Des Moines to Chicago Loopcar car 330.9 mi
    5h 31m
    $61–88
  5. Fly to Chicago Midway International Airport, subway

    1. Fly from Des Moines (DSM) to Chicago Midway International Airport (MDW)plane plane DSM - MDW
    2. Take the subway from Midway to Washington/Wellssubway subway
    2h 18m
    $110–626
  6. Bus via Des Moines (Greyhound)

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123 / ...
    7h 19m
    $60–103

Des Moines to Chicago Loop by bus

Calendar7Weekly Buses
Duration6h 10mAverage Duration
Ticket$65Cheapest Price
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Questions & Answers

What companies run services between Des Moines, IA, USA and Chicago Loop, IL, USA?

American Airlines and United Airlines fly from Des Moines (DSM) to Chicago O'Hare International Airport (ORD) every 2 hours. Alternatively, Burlington Trailways operates a bus from Des Moines to Chicago once daily. Tickets cost $65–143 and the journey takes 6h 10m.

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