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How to get fromDes Moines to Chicago Loopby plane, bus, car or bus (Greyhound)

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There are 6 ways to get from Des Moines to Chicago Loop by plane, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Chicago O'Hare International Airport

    best
    1. Fly from Des Moines (DSM) to Chicago O'Hare International Airport (ORD)planeDSM - ORD
    2h 28m
    $70–376
  2. Bus via Des Moines #2 (Greyhound)

    cheapest
    1. Take the bus from Des Moines to Chicago Bus StationbusGreyhound US0123 / ...
    8h 9m
    $49–95
  3. Bus

    1. Take the bus from Des Moines to ChicagobusOmaha
    6h 10m
    $65–143
  4. Drive 330.9 mi

    1. Drive from Des Moines to Chicago Loopcar330.9 mi
    5h 31m
    $61–88
  5. Fly to Chicago Midway International Airport

    1. Fly from Des Moines (DSM) to Chicago Midway International Airport (MDW)planeDSM - MDW
    2h 17m
    $95–526
  6. Bus via Des Moines

    1. Take the bus from Des Moines to ChicagobusDes Moines
    7h 29m
    $59–157

Des Moines to Chicago Loop by bus

Calendar7Weekly Buses
Duration6h 10mAverage Duration
Ticket$65Cheapest Price
See schedules

Questions & Answers

What companies run services between Des Moines, IA, USA and Chicago Loop, IL, USA?

American Airlines, United Airlines, and Delta fly from Des Moines (DSM) to Chicago O'Hare International Airport (ORD) every 2 hours. Alternatively, Burlington Trailways operates a bus from Des Moines to Chicago once daily. Tickets cost $65–143 and the journey takes 6h 10m.

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