There are 6 ways to get from Des Moines to Chicago Loop by plane, bus, car, or bus (Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Chicago O'Hare International Airport
best- Fly from Des Moines (DSM) to Chicago O'Hare International Airport (ORD)DSM - ORD
2h 28m$70–376Bus via Des Moines #2 (Greyhound)
cheapest- Take the bus from Des Moines to Chicago Bus StationGreyhound US0123 / ...
8h 9m$49–95Bus
- Take the bus from Des Moines to ChicagoOmaha
6h 10m$65–143Drive 330.9 mi
- Drive from Des Moines to Chicago Loop330.9 mi
5h 31m$61–88Fly to Chicago Midway International Airport
- Fly from Des Moines (DSM) to Chicago Midway International Airport (MDW)DSM - MDW
2h 17m$95–526Bus via Des Moines
- Take the bus from Des Moines to ChicagoDes Moines
7h 29m$59–157
Des Moines to Chicago Loop by bus
Questions & Answers
The cheapest way to get from Des Moines to Chicago Loop is to bus via Des Moines which costs $45 - $95 and takes 8h 9m.
The fastest way to get from Des Moines to Chicago Loop is to fly which takes 2h 17m and costs $95 - $550.
Yes, there is a direct bus departing from Des Moines and arriving at Chicago. Services depart once daily, and operate every day. The journey takes approximately 6h 10m.
The distance between Des Moines and Chicago Loop is 324 miles. The road distance is 332.9 miles.
The best way to get from Des Moines to Chicago Loop without a car is to bus which takes 6h 10m and costs $65 - $150.
It takes approximately 2h 28m to get from Des Moines to Chicago Loop, including transfers.
Des Moines to Chicago Loop bus services, operated by Burlington Trailways, depart from Des Moines station.
The best way to get from Des Moines to Chicago Loop is to fly which takes 2h 28m and costs $70 - $380. Alternatively, you can bus, which costs $65 - $150 and takes 6h 10m.
Des Moines to Chicago Loop bus services, operated by Burlington Trailways, arrive at Chicago station.
Yes, the driving distance between Des Moines to Chicago Loop is 333 miles. It takes approximately 5h 31m to drive from Des Moines to Chicago Loop.
What companies run services between Des Moines, IA, USA and Chicago Loop, IL, USA?
American Airlines, United Airlines, and Delta fly from Des Moines (DSM) to Chicago O'Hare International Airport (ORD) every 2 hours. Alternatively, Burlington Trailways operates a bus from Des Moines to Chicago once daily. Tickets cost $65–143 and the journey takes 6h 10m.
Transport is disrupted due to the Russia-Ukraine war. Read more
- Website
- aa.com
Flights from Des Moines to Chicago O'Hare International Airport
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- $50–350
- Website
- united.com
Flights from Des Moines to Chicago O'Hare International Airport
- Ave. Duration
- 1h 32m
- When
- Every day
- Estimated price
- $50–350
- Website
- southwest.com
Flights from Des Moines to Chicago Midway International Airport
- Ave. Duration
- 1h 20m
- When
- Monday, Thursday, and Friday
- Estimated price
- $75–500
Flights from Des Moines to Chicago Midway International Airport via St. Louis
- Ave. Duration
- 3h 30m
- When
- Monday, Tuesday, Wednesday, and Saturday
- Estimated price
- $95–550
- Website
- delta.com
Flights from Des Moines to Chicago O'Hare International Airport via Minneapolis
- Ave. Duration
- 4h 2m
- When
- Every day
- Estimated price
- $70–410
- Phone
- +1 (319) 753-2864
- info@burlingtontrailways.com
- Website
- burlingtontrailways.com
Bus from Des Moines to Chicago
- Ave. Duration
- 6h 10m
- Frequency
- Once daily
- Estimated price
- $65–143
- Website
- https://burlingtontrailways.com
- Saver Fares
- $65–100
- Flexible Fares
- $90–140
- Saver Fare
- $104
- Flex Fare
- $143
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Des Moines to Chicago Bus Station
- Ave. Duration
- 7h 55m
- Frequency
- 3 times a day
- Estimated price
- $45–95
- Website
- https://www.greyhound.com/
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
More Questions & Answers
There are 1226+ hotels available in Chicago Loop.





