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How to get fromDes Moines to Cape Codby plane, bus, train, bus (Flixbus) or car

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There are 8 ways to get from Des Moines to Cape Cod by plane, bus, train, bus (Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Boston Logan Airport, bus

    best
    1. Fly from Des Moines (DSM) to Boston Logan Airport (BOS)planeDSM - BOS
    2. Take the bus from Logan International Airport to Hyannis Transportation Centerbus
    6h 53m
    $189–764
  2. Bus, train

    1. Take the bus from Des Moines to Chicagobus
    2. Take the train from Chicago Union Station to Bostontrain
    3. Take the bus from Boston South Station to Hyannis Transportation Centerbus
    32h 50m
    $211–836
  3. Bus

    1. Take the bus from Des Moines to Chicagobus
    2. Take the bus from Chicago Bus Station to New York Midtownbus
    3. Take the bus from New York Midtown to Bostonbus
    4. Take the bus from Boston South Station to Hyannis Transportation Centerbus
    36h 9m
    $211–481
  4. Drive 1,345.5 mi

    1. Drive from Des Moines to Cape Codcar1,345.5 mi
    22h 54m
    $246–355
  5. Fly to Barnstable Municipal Airport

    1. Fly from Des Moines (DSM) to Barnstable Municipal Airport (HYA)planeDSM - HYA
    7h 2m
    $204–977
  6. Bus, train via Des Moines

    1. Take the bus from Des Moines to Chicagobus
    2. Take the train from Chicago Union Station to Bostontrain
    3. Take the bus from Boston South Buses to Hyannis Transportation Centerbus
    33h 53m
    $216–842
  7. Bus, train via Des Moines #2

    1. Take the bus from Des Moines to Chicago Bus Stationbus
    2. Take the train from Chicago Union Station to Bostontrain
    3. Take the bus from Boston South Buses to Hyannis Transportation Centerbus
    34h 33m
    $202–761
  8. Bus, train via Galesburg

    1. Take the bus from Des Moines to Burlingtonbus
    2. Take the bus from Burlington to Galesburgbus
    3. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain
    4. Take the train from Chicago Union Station to Bostontrain
    5. Take the bus from Boston South Station to Hyannis Transportation Centerbus
    35h 26m
    $229–880

Des Moines to Cape Cod by bus, foot, and train

Calendar7Weekly Services
Duration32h 50mAverage Duration
Ticket$211Cheapest Price
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Questions & Answers

What companies run services between Des Moines, IA, USA and Cape Cod, MA, USA?

You can take a bus from Des Moines to Town Hall Lawton Bus Shelter via Chicago Bus Station, New York Midtown, Boston, Boston South Station, and Hyannis Transportation Center in around 36h 9m. Alternatively, American Airlines, Allegiant Air, and two other airlines fly from Des Moines (DSM) to Barnstable Municipal Airport (HYA) twice daily.

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