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How to get fromDes Moines to Buffaloby plane, bus (Greyhound), bus, train, car or shuttle

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There are 6 ways to get from Des Moines to Buffalo by plane, bus (Greyhound), bus, train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Buffalo Niagara International Airport

    best
    1. Fly from Des Moines (DSM) to Buffalo Niagara International Airport (BUF)plane plane DSM - BUF
    5h 12m
    $363–1,949

  2. Bus

    cheapest
    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus bus
    3. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    19h 25m
    $114–239

  3. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123 / ...
    2. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    19h 58m
    $173–444

  4. Drive 848.1 mi

    1. Drive from Des Moines to Buffalocar car 848.1 mi
    14h 16m
    $155–224

  5. Fly to Rochester, bus

    1. Fly from Des Moines (DSM) to Rochester (ROC)plane plane DSM - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    6h 42m
    $244–1,165

  6. Fly to Toronto Pearson International Airport, shuttle

    1. Fly from Des Moines (DSM) to Toronto Pearson International Airport (YYZ)plane plane DSM - YYZ
    2. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    8h
    $208–719

Des Moines to Buffalo by bus

Calendar14Weekly Buses
Duration19h 25mAverage Duration
Ticket$114Cheapest Price
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Questions & Answers

What companies run services between Des Moines, IA, USA and Buffalo, NY, USA?

Southwest Airlines, Delta, and two other airlines fly from Des Moines (DSM) to Buffalo Niagara International Airport (BUF) every 3 hours. Alternatively, you can take a bus from Des Moines to Buffalo, NY via Chicago Bus Station, Cleveland Bus Station, and Cleveland, OH in around 19h 25m.

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