There are 6 ways to get from Des Moines to Buffalo by plane, bus (Greyhound), bus, train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Buffalo Niagara International Airport
best- Fly from Des Moines (DSM) to Buffalo Niagara International Airport (BUF)plane DSM - BUF
4h 57m$340–1,823Bus
cheapest- Take the bus from Des Moines to Chicago Bus Stationbus
- Take the bus from Chicago Bus Station to Cleveland Bus Stationbus
- Take the bus from Cleveland, OH to Buffalo, NYbus
20h 25m$118–246Bus, train
- Take the bus from Des Moines to Chicago Bus Stationbus Greyhound US0155S
- Take the train from Chicago Union Station to Buffalo Depew Stationtrain Lake Shore Limited
20h 58m$197–481Drive 848.1 mi
- Drive from Des Moines to Buffalocar 848.1 mi
14h 16m$155–224Fly to Rochester, bus
- Fly from Des Moines (DSM) to Rochester (ROC)plane DSM - ROC
- Take the bus from Rochester Bus Stop to Buffalobus
6h 42m$224–1,166Bus, train via Saint Paul
- Take the bus from Des Moines to St. Paulbus
- Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain
- Take the train from Chicago Union Station to Buffalo Depew Stationtrain
25h 58m$263–709
Des Moines to Buffalo by bus
Questions & Answers
The cheapest way to get from Des Moines to Buffalo is to bus which costs $110 - $250 and takes 20h 25m.
The fastest way to get from Des Moines to Buffalo is to fly which takes 4h 57m and costs $340 - $1,900.
No, there is no direct bus from Des Moines to Buffalo. However, there are services departing from Des Moines and arriving at Buffalo, NY via Chicago Bus Station and Cleveland, OH. The journey, including transfers, takes approximately 20h 25m.
The distance between Des Moines and Buffalo is 794 miles. The road distance is 853 miles.
The best way to get from Des Moines to Buffalo without a car is to bus which takes 20h 25m and costs $110 - $250.
It takes approximately 4h 57m to get from Des Moines to Buffalo, including transfers.
Des Moines to Buffalo bus services, operated by Greyhound USA, depart from Des Moines station.
The best way to get from Des Moines to Buffalo is to fly which takes 4h 57m and costs $340 - $1,900. Alternatively, you can bus, which costs $110 - $250 and takes 20h 25m.
Des Moines to Buffalo bus services, operated by Greyhound USA, arrive at Chicago Bus Station.
Buffalo is 1h ahead of Des Moines. It is currently 12:56 PM in Des Moines and 1:56 PM in Buffalo.
What companies run services between Des Moines, IA, USA and Buffalo, NY, USA?
Southwest Airlines, Delta, and two other airlines fly from Des Moines (DSM) to Buffalo Niagara International Airport (BUF) every 4 hours. Alternatively, you can take a bus from Des Moines to Buffalo, NY via Chicago Bus Station, Cleveland Bus Station, and Cleveland, OH in around 20h 25m.
- Website
- aa.com
Flights from Des Moines to Buffalo Niagara International Airport via Chicago O'Hare
- Ave. Duration
- 5h 4m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $320–1,800
Flights from Des Moines to Buffalo Niagara International Airport via Reagan Washington
- Ave. Duration
- 6h 4m
- When
- Sunday
- Estimated price
- $430–2,200
Flights from Des Moines to Rochester via Reagan Washington
- Ave. Duration
- 6h 41m
- When
- Every day
- Estimated price
- $240–1,200
Flights from Des Moines to Rochester via Chicago O'Hare
- Ave. Duration
- 6h 21m
- When
- Every day
- Estimated price
- $180–1,100
Flights from Des Moines to Rochester via Philadelphia
- Ave. Duration
- 5h 57m
- When
- Thursday
- Estimated price
- $240–1,300
- Website
- delta.com
Flights from Des Moines to Buffalo Niagara International Airport via Detroit
- Ave. Duration
- 4h 46m
- When
- Every day
- Estimated price
- $320–1,800
Flights from Des Moines to Buffalo Niagara International Airport via Minneapolis
- Ave. Duration
- 6h 42m
- When
- Monday, Thursday, and Sunday
- Estimated price
- $370–2,000
Flights from Des Moines to Rochester via Detroit
- Ave. Duration
- 4h 10m
- When
- Every day
- Estimated price
- $180–1,100
Flights from Des Moines to Rochester via New York La Guardia
- Ave. Duration
- 8h 43m
- When
- Every day
- Estimated price
- $250–1,300
- Website
- united.com
Flights from Des Moines to Buffalo Niagara International Airport via Chicago O'Hare
- Ave. Duration
- 4h 13m
- When
- Every day
- Estimated price
- $320–1,800
Flights from Des Moines to Rochester via Chicago O'Hare
- Ave. Duration
- 4h 28m
- When
- Every day
- Estimated price
- $180–1,100
- Website
- southwest.com
Flights from Des Moines to Buffalo Niagara International Airport via Chicago Midway
- Ave. Duration
- 3h 47m
- When
- Every day
- Estimated price
- $320–1,800
Flights from Des Moines to Rochester via Chicago Midway
- Ave. Duration
- 4h 5m
- When
- Tuesday and Wednesday
- Estimated price
- $180–1,100
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Chicago Union Station to Buffalo Depew Station
- Ave. Duration
- 10h 23m
- Frequency
- Twice daily
- Estimated price
- $130–300
- Website
- https://www.amtrak.com/home.html
Train from St. Paul-Minneapolis to Chicago Union Station
- Ave. Duration
- 7h 24m
- Frequency
- 3 times a day
- Estimated price
- $100–230
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Des Moines to Chicago Bus Station
- Ave. Duration
- 8h 5m
- Frequency
- Once daily
- Estimated price
- $55–110
- Website
- https://www.greyhound.com/
Bus from Chicago Bus Station to Cleveland Bus Station
- Ave. Duration
- 7h 10m
- Frequency
- Twice daily
- Estimated price
- $55–110
- Website
- https://www.greyhound.com/
Bus from Cleveland, OH to Buffalo, NY
- Ave. Duration
- 4h
- Frequency
- Once daily
- Estimated price
- $30–60
- Website
- https://www.greyhound.com/
Bus from Rochester Bus Stop to Buffalo
- Ave. Duration
- 1h 25m
- Frequency
- 4 times a day
- Estimated price
- $12–23
- Website
- https://www.greyhound.com/
- Phone
- +1 888-378-3823
- info@baronsbus.com
- Website
- baronsbus.com
Bus from Chicago Bus Station to Cleveland Bus Station
- Ave. Duration
- 6h 55m
- Frequency
- Once daily
- Estimated price
- $30–80
- Website
- https://baronsbus.com
Bus from Cleveland, OH to Buffalo, NY
- Ave. Duration
- 3h 10m
- Frequency
- Once daily
- Estimated price
- $18–60
- Website
- https://baronsbus.com
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Rochester Bus Stop to Buffalo
- Ave. Duration
- 1h 20m
- Frequency
- Every 3 hours
- Estimated price
- $8–15
- Schedules at
- flixbus.com
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Des Moines to St. Paul
- Ave. Duration
- 4h 50m
- Frequency
- Once daily
- Estimated price
- $23–110
- Book at
- https://www.jeffersonlines.com
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More Questions & Answers
Yes, the driving distance between Des Moines to Buffalo is 853 miles. It takes approximately 14h 16m to drive from Des Moines to Buffalo.
Book your Des Moines to Buffalo bus tickets online with Omio and FlixBus.
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