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How to get fromDes Moines to Bostonby plane, bus, train, bus (Greyhound, Flixbus), or car

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There are 8 ways to get from Des Moines to Boston by plane, bus, train, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Manchester Airport, bus

    best
    1. Fly from Des Moines (DSM) to Manchester Airport (MHT)plane plane DSM - MHT
    2. Take the bus from Boston Manchester Airport to Bostonbus bus
    7h 17m
    $128–517

  2. Fly to Theodore Francis Green State Airport, train

    cheapest
    1. Fly from Des Moines (DSM) to Theodore Francis Green State Airport (PVD)plane plane DSM - PVD
    2. Take the train from TF Green Airport to South Stationtrain train
    7h 33m
    $103–409

  3. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the train from Chicago Union Station to Bostontrain train Lake Shore Limited
    30h 16m
    $609–987

  4. Bus

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to New York Midtownbus bus
    3. Take the bus from New York Midtown to Bostonbus bus
    33h 33m
    $239–367

  5. Drive  1,296.5 mi

    1. Drive from Des Moines to Bostoncar car 1,296.5 mi
    22h 5m
    $237–342

  6. Fly to Worcester Regional Airport, bus

    1. Fly from Des Moines (DSM) to Worcester Regional Airport (ORH)plane plane DSM - ORH
    2. Take the bus from Worcester Union Station to Bostonbus bus
    9h 58m
    $127–519

  7. Fly to Laguardia Airport, train

    1. Fly from Des Moines (DSM) to Laguardia Airport (LGA)plane plane DSM - LGA
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Bostontrain train
    8h 14m
    $272–879

  8. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Bostontrain train
    31h 27m
    $671–1,094

Des Moines to Boston by bus, foot, and train

Calendar7Weekly Services
Duration30h 16mAverage Duration
Ticket$609Cheapest Price
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Comparing Your Travel Options

Map of how to get from Des Moines to Boston.ExpandLaunch map view
  • Distance: 1,195.4 mi
  • Duration: 7h 17m

What companies run services between Des Moines, IA, USA and Boston, MA, USA?

You can take a bus from Des Moines to Boston via Chicago Bus Station and New York Midtown in around 33h 33m.

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