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How to get fromDes Moines to Appletonby plane, bus (Greyhound, Flixbus), car, bus, train or bus (Amtrak)

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There are 7 ways to get from Des Moines to Appleton by plane, bus (Greyhound, Flixbus), car, bus, train, or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Appleton International Airport

    best
    1. Fly from Des Moines (DSM) to Appleton International Airport (ATW)plane plane DSM - ATW
    3h 58m
    $127–644
  2. Drive 380.2 mi

    cheapest
    1. Drive from Des Moines to Appletoncar car 380.2 mi
    7h 4m
    $70–101
  3. Bus

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123 / ...
    2. Take the bus from Chicago Bus Station to Appleton Transit Centerbus bus FlixBus 2550
    12h 35m
    $76–139
  4. Fly to Green Bay

    1. Fly from Des Moines (DSM) to Green Bay (GRB)plane plane DSM - GRB
    5h 33m
    $143–664
  5. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Milwaukeetrain train
    3. Take the bus from Milwaukee to Appleton Amtrak Stationbus bus
    13h 7m
    $85–194
  6. Bus via Saint Paul

    1. Take the bus from Des Moines to St. Paulbus bus
    2. Take the bus from St. Paul-Minneapolis to Wausau Amtrak Bus Stopbus bus
    3. Take the bus from Wausau Transit Center to Appletonbus bus
    13h 30m
    $97–220
  7. Bus, train via Saint Paul

    1. Take the bus from Des Moines to St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Milwaukeetrain train
    3. Take the bus from Milwaukee to Appleton Amtrak Stationbus bus
    15h 4m
    $106–324

Des Moines to Appleton by bus

Calendar5Weekly Buses
Duration12h 35mAverage Duration
Ticket$76Cheapest Price
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Questions & Answers

What companies run services between Des Moines, IA, USA and Appleton, WI, USA?

American Airlines, United Airlines, and Delta fly from Des Moines (DSM) to Appleton International Airport (ATW) every 2 hours. Alternatively, you can take a bus from Des Moines to Appleton Transit Center via Chicago Bus Station in around 12h 35m.

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