Rome2Rio

How to get fromDepew to Milwaukeeby plane, train (Amtrak), bus (Greyhound, Flixbus), car, train or bus

Find Transport to Milwaukee

See all options

There are 5 ways to get from Depew to Milwaukee by plane, train (Amtrak), bus (Greyhound, Flixbus), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Buffalo Niagara International Airport (BUF) to General Mitchell International Airport (MKE)plane plane BUF - MKE
    4h 6m
    $210–1,223

  2. Bus

    cheapest
    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    17h 24m
    $73–177

  3. Train (Amtrak)

    1. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    2. Take the train from Chicago Union Station to Milwaukeetrain train Hiawatha Service / ...
    14h 8m
    $165–377

  4. Drive 623.9 mi

    1. Drive from Depew to Milwaukeecar car 623.9 mi
    10h 48m
    $114–165

  5. Train, bus

    1. Take the train from Buffalo to Toronto Union Stationtrain train
    2. Take the bus from Toronto to Detroit Bus Stationbus bus
    3. Take the bus from Detroit Bus Station to Milwaukee Intermodal Stationbus bus
    22h 10m
    $100–227

Depew to Milwaukee by bus and train (Amtrak)

Calendar14Weekly Services
Duration14h 8mAverage Duration
Ticket$165Cheapest Price
See schedules

Questions & Answers

What companies run services between Depew, NY, USA and Milwaukee, WI, USA?

Southwest Airlines, Delta, and three other airlines fly from Buffalo Niagara International Airport (BUF) to General Mitchell International Airport (MKE) every 2 hours. Alternatively, you can take a bus from Broadway & Meridian Street to Milwaukee via Dick Road & AMTRAK Station, Buffalo Depew Station, and Chicago Union Station in around 14h 8m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers

Where to next?

Trips from Depew

Trips to Milwaukee

Popular routes