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How to get fromDepew to Clevelandby train (Amtrak), bus (Greyhound), car, or plane

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There are 4 ways to get from Depew to Cleveland by train (Amtrak), bus (Greyhound), car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Buffalo Depew Station to Cleveland Amtraktrain train Lake Shore Limited
    4h 20m
    $52–122

  2. Drive 193.5 mi

    cheapest
    1. Drive from Depew to Clevelandcar car 193.5 mi
    3h 26m
    $36–51

  3. Bus (Greyhound)

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus Greyhound US0171 / ...
    6h 20m
    $38–73

  4. Fly

    1. Fly from Buffalo Niagara International Airport (BUF) to Cleveland-Hopkins International Airport (CLE)plane plane BUF - CLE
    3h 45m
    $140–823

Depew to Cleveland by bus and train (Amtrak)

Calendar14Weekly Services
Duration4h 20mAverage Duration
Ticket$52Cheapest Price
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Questions & Answers

What companies run services between Depew, NY, USA and Cleveland, OH, USA?

Amtrak operates a train from Buffalo Depew Station to Cleveland Amtrak twice daily. Tickets cost $50–120 and the journey takes 3h 14m. Alternatively, Greyhound USA operates a bus from Buffalo to Cleveland Bus Station twice daily. Tickets cost $30–65 and the journey takes 3h 15m.

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