Rome2Rio

How to get fromDenver to Murphysboroby plane, bus (Greyhound, Amtrak, Flixbus), car, or bus

Find Transport to Murphysboro

See all options

There are 5 ways to get from Denver to Murphysboro by plane, bus (Greyhound, Amtrak, Flixbus), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Williamson County Regional Airport

    best
    1. Fly from Denver (DEN) to Williamson County Regional Airport (MWA)plane plane DEN - MWA
    7h 10m
    $175–480

  2. Bus

    cheapest
    1. Take the bus from Denver Union Station to St Louis Bus Stationbus bus Greyhound US1200 / ...
    2. Take the bus from St. Louis to Carbondalebus bus Amtrak Thruway Connecting Service
    19h 40m
    $155–299

  3. Drive 929.6 mi

    1. Drive from Denver to Murphysborocar car 929.6 mi
    15h 16m
    $170–245

  4. Fly to Lambert–St. Louis International Airport, bus

    1. Fly from Denver (DEN) to Lambert–St. Louis International Airport (STL)plane plane DEN - STL
    2. Take the bus from St. Louis to Carbondalebus bus
    7h 34m
    $225–581

  5. Fly to Nashville, bus

    1. Fly from Denver (DEN) to Nashville (BNA)plane plane DEN - BNA
    2. Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus bus
    9h 55m
    $240–685

Denver (DEN) to Williamson County Regional Airport (MWA) flights

Calendar28Weekly Planes
Duration6h 40mAverage Duration
Ticket$106Cheapest Price
See schedules

Questions & Answers

Map of how to get from Denver to Murphysboro.ExpandLaunch map view
  • Distance: 897.3 mi
  • Duration: 7h 10m

What companies run services between Denver, CO, USA and Murphysboro, IL, USA?

American Airlines, United Airlines, and three other airlines fly from Denver (DEN) to Williamson County Regional Airport (MWA) 4 times a day. Alternatively, you can take a bus from Denver Union Station to Murphysboro via St Louis Bus Station, St. Louis, and Carbondale in around 19h 40m.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers