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How to get fromDenver to Murphysboroby plane, bus (Greyhound, Flixbus, Amtrak), train (Amtrak), car, or bus

Find Transport to Murphysboro

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There are 6 ways to get from Denver to Murphysboro by plane, bus (Greyhound, Flixbus, Amtrak), train (Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Williamson County Regional Airport

    best
    1. Fly from Denver (DEN) to Williamson County Regional Airport (MWA)plane plane DEN - MWA
    7h 22m
    $140–502

  2. Bus

    1. Take the bus from Denver Union Station to St Louis Bus Stationbus bus Greyhound US1200 / ...
    2. Take the bus from St Louis Bus Station to Carbondale Intermodal Stationbus bus FlixBus N2521
    19h 45m
    $192–279

  3. Train (Amtrak)

    1. Take the train from Denver to Chicago Union Stationtrain train California Zephyr
    2. Take the train from Chicago Union Station to Carbondaletrain train Saluki / ...
    25h 20m
    $756–1,153

  4. Drive  929.6 mi

    1. Drive from Denver to Murphysborocar car 929.6 mi
    15h 16m
    $159–230

  5. Fly to Lambert–St. Louis International Airport, bus

    1. Fly from Denver (DEN) to Lambert–St. Louis International Airport (STL)plane plane DEN - STL
    2. Take the bus from St Louis Bus Station to Carbondale Intermodal Stationbus bus
    7h 19m
    $187–546

  6. Fly to Nashville, bus

    1. Fly from Denver (DEN) to Nashville (BNA)plane plane DEN - BNA
    2. Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus bus
    9h 40m
    $232–602

Denver (DEN) to Williamson County Regional Airport (MWA) flights

Calendar14Weekly Planes
Duration5h 22mAverage Duration
Ticket$94Cheapest Price
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Comparing Your Travel Options

Map of how to get from Denver to Murphysboro.ExpandLaunch map view
  • Distance: 897.3 mi
  • Duration: 7h 22m

What companies run services between Denver, CO, USA and Murphysboro, IL, USA?

American Airlines and United Airlines fly from Denver (DEN) to Williamson County Regional Airport (MWA) twice daily. Alternatively, you can take a bus from Denver Union Station to Murphysboro via St Louis Bus Station and Carbondale Intermodal Station in around 19h 45m.

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