There are 5 ways to get from Denver to Knoxville by plane, train, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  4 h 47 min

  1. Fly from Denver (DEN) to Knoxville (TYS) DEN - TYS

$254 - $879

Cheapest option

Bus  •  32 h 38 min

  1. Take the bus from Denver, Co to Frisco
  2. Take the bus from Frisco to St Louis, Mo
  3. Take the bus from St Louis, Mo to Nashville, Tn
  4. Take the bus from Nashville, Tn to Knoxville, Tn

$157 - $390

3 alternative options

Train, Megabus, bus  •  31 h 20 min

  1. Take the train from Denver Union Station Amtrak to Chicago Union Station Amtrak
  2. Take the Megabus from Chicago to University of Cincinnati
  3. Take the bus from Cincinnati, Oh to Knoxville, Tn

$198 - $515

Bus Burlington Trailways  •  35 h 27 min

  1. Take the bus from Denver, CO to Indianapolis, IN
  2. Take the bus from Indianapolis, IN to Cincinnati, OH
  3. Take the bus from Cincinnati, Oh to Knoxville, Tn

$186 - $304

Drive  •  21 h 9 min

  1. Drive from Denver to Knoxville 1340.1 miles

$130 - $190

Questions & Answers

The cheapest way to get from Denver to Knoxville is to drive which costs $130 - $190 and takes 21 h 9 min.

More details

The quickest way to get from Denver to Knoxville is to fly which costs $250 - $900 and takes 4 h 47 min.

More details

The distance between Denver and Knoxville is 1182 miles. The road distance is 1340.1 miles.

Get driving directions

It takes approximately 4 h 47 min to get from Denver to Knoxville, including transfers.

More details

No, there is no direct bus from Denver to Knoxville. However, there are services departing from Denver, Co and arriving at Knoxville, Tn via Frisco, St Louis, Mo and Nashville, Tn. The journey, including transfers, takes approximately 32 h 38 min.

More details

What companies run services between Denver, CO, USA and Knoxville, TN, USA?

Frontier Airlines, United Airlines and two other airlines fly from Denver to Knoxville hourly. Alternatively, you can take a bus from Denver to Knoxville via Frisco, St Louis, Mo, and Nashville, Tn in around 32 h 38 min.

Airlines
Delta
Website
delta.com
Flights from Denver to Knoxville via Atlanta
Ave. Duration
5 h 8 min
When
Every day
Estimated price
$330 - $900
American Airlines
Website
aa.com
Flights from Denver to Knoxville via Charlotte
Ave. Duration
5 h 12 min
When
Every day
Estimated price
$370 - $950
Flights from Denver to Knoxville via Chicago O'Hare
Ave. Duration
5 h 20 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$370 - $950
Flights from Denver to Knoxville via Dallas/Ft.Worth
Ave. Duration
5 h 19 min
When
Every day
Estimated price
$370 - $950
United Airlines
Website
united.com
Flights from Denver to Knoxville
Ave. Duration
2 h 54 min
When
Every day
Estimated price
$370 - $900
Frontier Airlines
Website
flyfrontier.com
Flights from Denver to Knoxville
Ave. Duration
2 h 48 min
When
Monday, Wednesday, Friday and Saturday
Estimated price
$150 - $700
Train operators
Amtrak
Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Denver Union Station Amtrak to Chicago Union Station Amtrak
Ave. Duration
18 h 40 min
Frequency
Once daily
Estimated price
$130 - $400
Website
amtrak.com
Coach Seat
$130 - $200
Flexi Coach Seat
$240 - $350
Business Coach Seat
$280 - $400
Room
$500 - $750
Bus operators
Greyhound USA
Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Cincinnati, Oh to Knoxville, Tn
Ave. Duration
5 h 20 min
Frequency
Every 30 minutes
Estimated price
$29 - $75
Website
greyhound.com
Economy
$29 - $50
Flexible
$55 - $75
Bus from Denver, Co to Frisco
Ave. Duration
1 h 45 min
Frequency
Hourly
Estimated price
$13 - $30
Website
greyhound.com
Economy
$13 - $20
Flexible
$23 - $30
Bus from Frisco to St Louis, Mo
Ave. Duration
19 h 35 min
Frequency
Every 4 hours
Estimated price
$85 - $220
Website
greyhound.com
Economy
$85 - $150
Flexible
$170 - $220
Bus from St Louis, Mo to Nashville, Tn
Ave. Duration
5 h 40 min
Frequency
Hourly
Estimated price
$35 - $85
Website
greyhound.com
Economy
$35 - $55
Flexible
$65 - $85
Bus from Nashville, Tn to Knoxville, Tn
Ave. Duration
4 h
Frequency
Every 20 minutes
Estimated price
$23 - $55
Website
greyhound.com
Economy
$23 - $35
Flexible
$40 - $55
Burlington Trailways

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