There are 4 ways to get from Denver to Knoxville by plane, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  4 h 48 min

  1. Fly from Denver (DEN) to Knoxville (TYS) DEN - TYS

$254 - $879

Cheapest option

Bus  •  32 h 31 min

  1. Take the bus from Denver, Co to Frisco
  2. Take the bus from Frisco to St Louis, Mo
  3. Take the bus from St Louis, Mo to Nashville, Tn
  4. Take the bus from Nashville, Tn to Knoxville, Tn

$157 - $390

2 alternative options

Bus Burlington Trailways  •  34 h 1 min

  1. Take the bus from Denver, CO to Indianapolis, IN
  2. Take the bus from Indianapolis, IN to University of Cincinnati
  3. Take the bus from Cincinnati, Oh to Knoxville, Tn

$180 - $293

Drive  •  21 h 9 min

  1. Drive from Denver to Knoxville 1340.1 miles

$130 - $190

Questions & Answers

No, there is no direct bus from Denver to Knoxville. However, there are services departing from Denver, Co and arriving at Knoxville, Tn via Frisco, St Louis, Mo and Nashville, Tn. The journey, including transfers, takes approximately 32 h 31 min.

More details

The distance between Denver and Knoxville is 1182 miles. The road distance is 1340.1 miles.

Get driving directions

The best way to get from Denver to Knoxville without a car is to bus which takes 32 h 31 min and costs .

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It takes approximately 4 h 48 min to get from Denver to Knoxville, including transfers.

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Denver to Knoxville bus services, operated by Greyhound USA, depart from Denver, Co station.

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The best way to get from Denver to Knoxville is to fly which takes 4 h 48 min and costs . Alternatively, you can bus, which costs and takes 32 h 31 min.

Mode details

The quickest flight from Denver Airport to Knoxville Airport is the direct flight which takes 2 h 49 min.

Search flights

Denver to Knoxville bus services, operated by Greyhound USA, arrive at Knoxville, Tn station.

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Knoxville is 2 h ahead of Denver. It is currently 3:59 PM in Denver and 5:59 PM in Knoxville.

Yes, the driving distance between Denver to Knoxville is 1340 miles. It takes approximately 21 h 9 min to drive from Denver to Knoxville.

Get driving directions

Map of how to get from Denver to Knoxville.
Launch map view
  • Distance: 1182.4 miles
  • Duration: 4 h 48 min

What companies run services between Denver, CO, USA and Knoxville, TN, USA?

Frontier Airlines, United Airlines and two other airlines fly from Denver to Knoxville hourly. Alternatively, you can take a bus from Denver to Knoxville via Frisco, St Louis, Mo, and Nashville, Tn in around 32 h 31 min.

Airlines
American Airlines
Website
aa.com
Flights from Denver to Knoxville via Charlotte
Ave. Duration
5 h 9 min
When
Every day
Estimated price
$370 - $950
Flights from Denver to Knoxville via Dallas/Ft.Worth
Ave. Duration
5 h 14 min
When
Every day
Estimated price
$370 - $950
Flights from Denver to Knoxville via Chicago O'Hare
Ave. Duration
5 h 22 min
When
Monday, Thursday and Friday
Estimated price
$370 - $950
Delta
Website
delta.com
Flights from Denver to Knoxville via Atlanta
Ave. Duration
5 h
When
Every day
Estimated price
$330 - $900
Flights from Denver to Knoxville via Minneapolis
Ave. Duration
5 h 8 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$330 - $900
United Airlines
Website
united.com
Flights from Denver to Knoxville
Ave. Duration
2 h 59 min
When
Every day
Estimated price
$370 - $900
Flights from Denver to Knoxville via Chicago O'Hare
Ave. Duration
5 h 4 min
When
Saturday
Estimated price
$370 - $900
Frontier Airlines
Website
flyfrontier.com
Flights from Denver to Knoxville
Ave. Duration
2 h 49 min
When
Tuesday, Thursday and Sunday
Estimated price
$150 - $700
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Denver, Co to Frisco
Ave. Duration
1 h 45 min
Frequency
Hourly
Estimated price
$13 - $30
Website
greyhound.com
Economy
$13 - $20
Flexible
$23 - $30
Bus from Frisco to St Louis, Mo
Ave. Duration
19 h 35 min
Frequency
Every 4 hours
Estimated price
$85 - $220
Website
greyhound.com
Economy
$85 - $150
Flexible
$170 - $220
Bus from St Louis, Mo to Nashville, Tn
Ave. Duration
5 h 40 min
Frequency
Every 30 minutes
Estimated price
$35 - $85
Website
greyhound.com
Economy
$35 - $55
Flexible
$65 - $85
Bus from Nashville, Tn to Knoxville, Tn
Ave. Duration
4 h
Frequency
Every 20 minutes
Estimated price
$23 - $55
Website
greyhound.com
Economy
$23 - $35
Flexible
$40 - $55
Bus from Cincinnati, Oh to Knoxville, Tn
Ave. Duration
5 h 20 min
Frequency
Every 30 minutes
Estimated price
$29 - $75
Website
greyhound.com
Economy
$29 - $50
Flexible
$55 - $75
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Bus from Denver Bus Center - Greyhound to Frisco
Ave. Duration
1 h 45 min
Frequency
Once daily
Website
amtrak.com
Burlington Trailways
Megabus

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More Questions & Answers

Frontier Airlines, United Airlines, Delta and American Airlines offer flights from Denver Airport to Knoxville Airport.

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Book your Denver to Knoxville bus tickets online with Greyhound, Greyhound and two other operators.

Search and book

There are 100+ hotels available in Knoxville. Prices start at $56 USD per night.

More details

The best way to get from Denver to Denver Airport is to train which takes 37 min and costs .

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