There are 5 ways to get from Defiance to St. Louis by taxi, plane, bus, train (Amtrak), car, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Taxi, fly
best- Take the taxi from Defiance to Fort Wayne International Airport (FWA)taxi
- Fly from Fort Wayne International Airport (FWA) to Lambert–St. Louis International Airport (STL)plane FWA - STL
5h 21m$252–830Drive 408.8 mi
cheapest- Drive from Defiance to St. Louiscar 408.8 mi
6h 57m$75–108Taxi, bus
- Take the taxi from Defiance to Van Werttaxi
- Take the bus from Van Wert to Fort Wayne, INbus
- Take the bus from Fort Wayne, IN to Indianapolis, INbus
- Take the bus from Indianapolis Union Station to St Louis Bus Stationbus
9h 42m$149–277Train (Amtrak)
- Take the train from Bryan Amtrak Station to Chicago Union Stationtrain Lake Shore Limited
- Take the train from Chicago Union Station to St. Louistrain Lincoln Service / ...
10h 5m$176–346Train, bus
- Take the train from Bryan Amtrak Station to Chicago Union Stationtrain Lake Shore Limited
- Take the bus from Chicago Bus Station to St Louis Bus Stationbus FlixBus N2521 / ...
11h 38m$136–246
Fort Wayne International Airport (FWA) to Lambert–St. Louis International Airport (STL) flights
Questions & Answers
The cheapest way to get from Defiance to St. Louis is to drive which costs $70 - $110 and takes 6h 57m.
The fastest way to get from Defiance to St. Louis is to taxi and fly which takes 5h 21m and costs $250 - $850.
The distance between Defiance and St. Louis is 385 miles. The road distance is 411.2 miles.
The best way to get from Defiance to St. Louis without a car is to taxi and bus which takes 9h 42m and costs $140 - $280.
It takes approximately 5h 21m to get from Defiance to St. Louis, including transfers.
St. Louis is 1h behind Defiance. It is currently 8:34 AM in Defiance and 7:34 AM in St. Louis.
Yes, the driving distance between Defiance to St. Louis is 411 miles. It takes approximately 6h 57m to drive from Defiance to St. Louis.
There are 877+ hotels available in St. Louis.
What companies run services between Defiance, OH, USA and St. Louis, MO, USA?
You can take a vehicle from Defiance to St. Louis via Bryan Amtrak Station and Chicago Union Station in around 10h 5m.
- Website
- aa.com
Flights from Fort Wayne International Airport to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 3h 54m
- When
- Every day
- Estimated price
- $100–650
Flights from Fort Wayne International Airport to Lambert–St. Louis International Airport via Dallas/Ft.Worth
- Ave. Duration
- 5h 49m
- When
- Every day
- Estimated price
- $220–1,100
Flights from Fort Wayne International Airport to Lambert–St. Louis International Airport via Charlotte
- Ave. Duration
- 6h 51m
- When
- Every day
- Estimated price
- $170–900
- Website
- united.com
Flights from Fort Wayne International Airport to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 4h 21m
- When
- Every day
- Estimated price
- $100–650
- Website
- delta.com
Flights from Fort Wayne International Airport to Lambert–St. Louis International Airport via Minneapolis
- Ave. Duration
- 5h 43m
- When
- Every day
- Estimated price
- $160–900
Flights from Fort Wayne International Airport to Lambert–St. Louis International Airport via Detroit
- Ave. Duration
- 6h 37m
- When
- Every day
- Estimated price
- $120–700
Flights from Fort Wayne International Airport to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 6h 34m
- When
- Every day
- Estimated price
- $170–900
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Bryan Amtrak Station to Chicago Union Station
- Ave. Duration
- 3h 49m
- Frequency
- Twice daily
- Estimated price
- $45–110
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to St. Louis
- Ave. Duration
- 4h 46m
- Frequency
- 5 times a day
- Estimated price
- $75–170
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 888-378-3823
- info@baronsbus.com
- Website
- baronsbus.com
Bus from Van Wert to Fort Wayne, IN
- Ave. Duration
- 40 min
- Frequency
- Once daily
- Estimated price
- $3–35
- Website
- https://baronsbus.com
Bus from Fort Wayne, IN to Indianapolis, IN
- Ave. Duration
- 2h 15m
- Frequency
- Once daily
- Estimated price
- $12–50
- Website
- https://baronsbus.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Indianapolis Union Station to St Louis Bus Station
- Ave. Duration
- 3h 55m
- Frequency
- 3 times a day
- Estimated price
- $40–80
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Chicago Bus Station to St Louis Bus Station
- Ave. Duration
- 6h 10m
- Frequency
- 3 times a day
- Estimated price
- $35–70
- Schedules at
- flixbus.com
- Ave. Duration
- 59 min
- Estimated price
- $90–180
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