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How to get fromDefiance to St. Louisby taxi, plane, bus, train (Amtrak), car or train

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There are 5 ways to get from Defiance to St. Louis by taxi, plane, bus, train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi, fly

    best
    1. Take the taxi from Defiance to Fort Wayne International Airport (FWA)taxi
    2. Fly from Fort Wayne International Airport (FWA) to Lambert–St. Louis International Airport (STL)planeFWA - STL
    5h 34m
    $227–660

  2. Drive 408.8 mi

    cheapest
    1. Drive from Defiance to St. Louiscar408.8 mi
    6h 53m
    $75–108

  3. Taxi, bus

    1. Take the taxi from Defiance to Van Werttaxi
    2. Take the bus from Van Wert to Fort Wayne, INbus
    3. Take the bus from Fort Wayne, IN to Indianapolis, INbus
    4. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus
    9h 42m
    $149–277

  4. Train (Amtrak)

    1. Take the train from Bryan Amtrak Station to Chicago Union StationtrainLake Shore Limited
    2. Take the train from Chicago Union Station to St. LouistrainLincoln Service / ...
    10h 5m
    $141–526

  5. Train, bus

    1. Take the train from Bryan Amtrak Station to Chicago Union StationtrainLake Shore Limited
    2. Take the bus from Chicago Bus Station to St Louis Bus StationbusFlixBus N2521 / ...
    11h 38m
    $141–256

Fort Wayne International Airport (FWA) to Lambert–St. Louis International Airport (STL) flights

Calendar102Weekly Planes
Duration5h 41mAverage Duration
Ticket$79Cheapest Price
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Questions & Answers

What companies run services between Defiance, OH, USA and St. Louis, MO, USA?

You can take a vehicle from Defiance to St. Louis via Bryan Amtrak Station and Chicago Union Station in around 10h 5m.

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