Rome2Rio

How to get fromDefiance to Pittsburghby bus (Amtrak, Greyhound), bus, train, car, taxi, plane, or train (Amtrak)

Find Transport to Pittsburgh

See all options

There are 5 ways to get from Defiance to Pittsburgh by bus (Amtrak, Greyhound), bus, train, car, taxi, plane, or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Bryan Amtrak Station to Toledobus bus Amtrak Thruway Connecting Service
    2. Take the bus from Toledo Bus Stop to Pittsburgh Intermodal Stationbus bus Greyhound US0420 / ...
    7h 5m
    $109–170

  2. Drive 275.8 mi

    cheapest
    1. Drive from Defiance to Pittsburghcar car 275.8 mi
    4h 33m
    $51–73

  3. Bus, train (Amtrak)

    1. Take the bus from Bryan Amtrak Station to Toledobus bus Amtrak Thruway Connecting Service
    2. Take the train from Toledo to Pittsburgh Amtrak Stationtrain train Floridian
    8h 11m
    $144–245

  4. Taxi, fly

    1. Take the taxi from Defiance to Fort Wayne International Airport (FWA)taxi taxi
    2. Fly from Fort Wayne International Airport (FWA) to Pittsburgh International Airport (PIT)plane plane FWA - PIT
    6h
    $199–527

  5. Train (Amtrak)

    1. Take the train from Bryan Amtrak Station to Toledotrain train Lake Shore Limited
    2. Take the train from Toledo to Pittsburgh Amtrak Stationtrain train Floridian
    8h 12m
    $141–251

Fort Wayne International Airport (FWA) to Pittsburgh International Airport (PIT) flights

Calendar94Weekly Planes
Duration5h 20mAverage Duration
Ticket$51Cheapest Price
See schedules

Questions & Answers

What companies run services between Defiance, OH, USA and Pittsburgh, PA, USA?

You can take a vehicle from Defiance to Pittsburgh Intermodal Station via Bryan Amtrak Station and Toledo Bus Stop in around 7h 5m. Alternatively, you can take a vehicle from Defiance to Pittsburgh Amtrak Station via Bryan Amtrak Station and Toledo in around 8h 12m.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Where to next?

Trips from Defiance

Trips to Pittsburgh

Popular routes