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How to get fromDeWitt to Chicagoby bus, plane, train (Amtrak), bus (Greyhound), car, or train

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There are 8 ways to get from DeWitt to Chicago by bus, plane, train (Amtrak), bus (Greyhound), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Syracuse Hancock International Airport, fly to Chicago O'Hare International Airport

    best
    1. Take the bus from E Genesee St & The Jewish Home to A1bus bus
    2. Fly from Syracuse Hancock International Airport (SYR) to Chicago O'Hare International Airport (ORD)plane plane SYR - ORD
    6h 1m
    $79–441

  2. Train (Amtrak)

    1. Take the train from Syracuse Regional Transportation Center to Chicago Union Stationtrain train Lake Shore Limited
    13h 20m
    $251–489

  3. Bus (Greyhound)

    1. Take the bus from Syracuse Bus Station to Cleveland Bus Stationbus bus Greyhound US0171
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    17h 7m
    $102–226

  4. Drive 680.3 mi

    1. Drive from DeWitt to Chicagocar car 680.3 mi
    11h 39m
    $125–180

  5. Fly Syracuse Hancock International Airport to Chicago Midway International Airport

    1. Fly from Syracuse Hancock International Airport (SYR) to Chicago Midway International Airport (MDW)plane plane SYR - MDW
    7h 37m
    $94–511

  6. Train to Rochester, fly to Chicago Midway International Airport

    1. Take the train from Syracuse Regional Transportation Center to Rochestertrain train
    2. Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane plane ROC - MDW
    6h 43m
    $124–664

  7. Train to Rochester, fly to Chicago O'Hare International Airport

    1. Take the train from Syracuse Regional Transportation Center to Rochestertrain train
    2. Fly from Rochester (ROC) to Chicago O'Hare International Airport (ORD)plane plane ROC - ORD
    7h 13m
    $109–594

  8. Bus to Buffalo Niagara International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Syracuse Bus Station to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    7h 49m
    $191–481

DeWitt to Chicago by bus (Greyhound)

Calendar14Weekly Buses
Duration17h 7mAverage Duration
Ticket$102Cheapest Price
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Comparing Your Travel Options

Map of how to get from DeWitt to Chicago.ExpandLaunch map view
  • Distance: 641.7 mi
  • Duration: 6h 1m

What companies run services between DeWitt, NY, USA and Chicago, IL, USA?

Amtrak operates a train from Syracuse Regional Transportation Center to Chicago Union Station twice daily. Tickets cost $210–440 and the journey takes 13h 7m. Alternatively, you can take a bus from E Genesee St & Terrace Dr to Chicago Bus Station via B8, Syracuse Bus Station, and Cleveland Bus Station in around 17h 7m.

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