COVID-19 Travel restrictions may apply upon entering Chile. Learn More.

There are 5 ways to get from Cusco to Santiago by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  4h 3m

  1. Fly from Cuzco (CUZ) to Santiago (SCL) CUZ - SCL

$107 - $450

Cheapest option

Bus  •  47h 39m

  1. Take the bus from Cusco to Tacna
  2. Take the bus from Tacna to Arica
  3. Take the bus from Arica to Santiago - Terminal San Borja

$70 - $145

3 alternative options

Bus via Achocalla  •  42h 43m

  1. Take the bus from Cusco to La Paz
  2. Take the bus from La Paz to Iquique
  3. Take the bus from Iquique to Santiago

$99 - $157

Train, bus  •  2 days 2h

  1. Take the train from Cusco - Wanchaq to Puno
  2. Take the bus from Puno to Tacna
  3. Take the bus from Tacna to Arica
  4. Take the bus from Arica to Santiago - Terminal San Borja

$342 - $417

Drive  •  35h 33m

  1. Drive from Cusco to Santiago 2878.3 km

$290 - $430

Cusco to Santiago by bus

The bus journey time between Cusco and Santiago is around 3 days 9h and covers a distance of around 3124 km. The fastest bus normally takes 3 days 9h. Services are operated by Trans Salvador, Nuevo Continente Internacional, Transportes 6 de Junio and others. Typically five buses run weekly, although weekend and holiday schedules can vary so check in advance.

The schedules shown below are for the next available departures.

Cusco to Santiago bus schedules

Peru → Chile
Restricted

Travel safe during COVID-19

International entry into Chile from Peru

  • Entry is restricted for citizens and permanent residents of Peru
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Allowed for: Citizens and permanent residents

Restricted for: Foreign nationals

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Conditions of entry into Chile from Peru

  • Negative COVID-19 test issued at most 3 days before arrival
  • 5 days mandatory government quarantine at traveller’s expense with covid-19 test on arrival. 5 of days self quarantine to be completed after negative covid-19 test issued
  • Health declaration required
This applies to arrivals from all countries, with no exceptions

Rules to follow in Chile

1m

Mandatory

Considerations leaving from Peru

The official advice is to avoid non-essential international travel to high risk countries

Frequently Asked Questions


No, entry into Chile from Peru is currently restricted.

Explore options for future travel

Domestic travel is restricted

  • Face masks are mandatory
  • There is a social distancing requirement of 1 metre
  • Domestic border crossings may be subject to approval, testing and quarantine
  • Regional restriction measures in place
  • Observe COVID-19 safety rules

Explore travel options

The national COVID-19 helpline number in Santiago is 600 360 7777.

Wearing a face mask on public transport in Santiago is mandatory.

The social distance requirement in Santiago is 1 metre.

Make yourself known to an official member of staff and/or call the national coronavirus helpline number on 600 360 7777.

No, but conditions apply when returning to Peru from Chile.

See options for return travel.

Last updated: 12 May 2021
Exceptions may apply, for full details: Chile Atiende.

We're working around the clock to bring you the latest COVID-19 travel updates.
This information is compiled from official sources. To the best of our knowledge, it is correct as of the last update.
Visit Rome2rio travel advice for general help.

Questions & Answers

The cheapest way to get from Cusco to Santiago is to bus which costs $70 - $150 and takes 47h 39m.

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The fastest way to get from Cusco to Santiago is to fly which takes 4h 3m and costs $100 - $450.

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No, there is no direct bus from Cusco to Santiago. However, there are services departing from Cusco and arriving at Santiago via La Paz and Iquique. The journey, including transfers, takes approximately 42h 43m.

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The distance between Cusco and Santiago is 2221 km. The road distance is 2878.3 km.

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The best way to get from Cusco to Santiago without a car is to bus via Achocalla which takes 42h 43m and costs $95 - $160.

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It takes approximately 4h 3m to get from Cusco to Santiago, including transfers.

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Cusco to Santiago bus services, operated by Trans Salvador, depart from Cusco station.

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The best way to get from Cusco to Santiago is to fly which takes 4h 3m and costs $100 - $450. Alternatively, you can bus via Achocalla, which costs $95 - $160 and takes 42h 43m.

Mode details

The quickest flight from Cuzco Airport to Santiago Airport is the direct flight which takes 3h 21m.

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Cusco to Santiago bus services, operated by Ramos Cholele, arrive at Santiago station.

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Map of how to get from Cusco to Santiago.
Launch map view
  • Distance: 2220.6 km
  • Duration: 4h 3m

What companies run services between Cusco, Peru and Santiago, Chile?

LATAM Chile flies from Cusco to Santiago once daily. Alternatively, you can take a bus from Cusco to Santiago via La Paz and Iquique in around 42h 43m.

Airlines
LATAM Chile
Website
latam.com
Flights from Cuzco to Santiago
Ave. Duration
3h 21m
When
Wednesday, Friday and Sunday
Estimated price
$100 - $1,900
Flights from Cuzco to Santiago via Lima
Ave. Duration
7h 25m
When
Monday, Tuesday, Wednesday, Thursday and Sunday
Estimated price
$100 - $1,900
Train operators
PeruRail
Phone
51-84-581414
Email
reservas@perurail.com
Website
perurail.com
Train from Cusco - Wanchaq to Puno
Ave. Duration
10h 28m
Frequency
4 times a week
Estimated price
$285
Schedules at
perurail.com
Book at
pax1.perurail.com
Bus operators
Trans Salvador
Phone
+56 58 222 8547
Email
central@trans-salvador.com
Website
trans-salvador.com
Bus from Cusco to La Paz
Ave. Duration
14h
Frequency
Once daily
Estimated price
$24
Schedules at
facebook.com
Book at
ticketsbolivia.com.bo
Bus from La Paz to Iquique
Ave. Duration
14h
Frequency
Once daily
Estimated price
$16
Schedules at
facebook.com
Book at
ticketsbolivia.com.bo
Nuevo Continente Internacional
Phone
(+591) 2-2283842 / (+591)2-2285191
Website
es-la.facebook.com
Bus from Cusco to La Paz
Ave. Duration
15h
Frequency
Once daily
Estimated price
$27
Schedules at
nuevocontinentesrl.wixsite.com
Book at
ticketsbolivia.com.bo
Transportes 6 de Junio
Phone
+591 22455258 / 22280890
Website
andestransit.com
Bus from Cusco to La Paz
Ave. Duration
15h
Frequency
Once daily
Estimated price
$50
Schedules at
andestransit.com
Bus Fer
Phone
+59 17 249 7088
Website
facebook.com
Bus from La Paz to Iquique
Ave. Duration
8h 46m
Frequency
Hourly
Estimated price
$36
Schedules at
es-la.facebook.com
Transporte Internacional Litoral
Phone
+591 2 2281920
Email
buslitoral@hotmail.com
Website
litoral-miramar.com
Bus from La Paz to Iquique
Ave. Duration
15h
Frequency
Once daily
Estimated price
$18
Schedules at
facebook.com
Pullman Bus
Phone
+56 600 600 0018
Website
pullmanbus.com
Bus from Iquique to Santiago - Terminal San Borja
Ave. Duration
24h
Frequency
Every 4 hours
Estimated price
$35 - $90
Schedules at
pullmanbus.com
Semi Cama
$35 - $60
Salón Cama
$60 - $90
Bus from Arica to Santiago - Terminal San Borja
Ave. Duration
28h 35m
Frequency
3 times a day
Estimated price
$45 - $110
Schedules at
pullmanbus.com
Semi Cama
$45 - $65
Salón Cama
$70 - $110
Cromotex
Phone
+51 (01) 424-75-75
Email
informes@cromotex.com.pe
Website
cromotex.com.pe
Bus from Cusco to Tacna
Ave. Duration
17h
Frequency
Once daily
Estimated price
$22
Schedules at
cromotex.com.pe
Book at
cromotex.com.pe
Buses Norte Grande
Phone
+56 58 222 8603
Email
reservas@busesng.cl
Website
busesng.cl
Bus from Tacna to Arica
Ave. Duration
1h
Frequency
Every 15 minutes
Estimated price
$3
Schedules at
busesng.cl
Chasquitur
Phone
+56 58 231967
Website
terminaldebuses.com
Bus from Tacna to Arica
Ave. Duration
1h
Frequency
Every 30 minutes
Estimated price
$3
Schedules at
terminaldebuses.com
Adsubliata
Phone
+56 58 262 495
Website
terminaldebuses.com
Bus from Tacna to Arica
Ave. Duration
1h
Frequency
Hourly
Estimated price
$3
Schedules at
terminaldebuses.com
Expreso Norte
Website
expresonorte.cl
Bus from Arica to Santiago
Ave. Duration
29h 40m
Frequency
4 times a day
Estimated price
$50 - $85
Website
Expreso Norte
Semi Cama
$50 - $70
Cama
$70 - $85
Turbus
Phone
+56 22 822 7500
Email
atencion_clientes@turbus.cl
Website
turbus.cl
Bus from Arica to Santiago - Borja Terminal
Ave. Duration
31h 50m
Frequency
4 times a day
Estimated price
$55 - $120
Schedules at
turbus.cl
Book at
turbus.cl
Semi Cama
$40 - $85
Premium
$80 - $120
Cama
$130 - $180
Fichtur VIP
Phone
+56 (02) 7205232
Bus from Arica to Santiago
Ave. Duration
28h 10m
Frequency
Once daily
Estimated price
$48
Schedules at
viajaenbus.cl

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More Questions & Answers

Santiago is 1h ahead of Cusco. It is currently 7:40 PM in Cusco and 8:40 PM in Santiago.

Yes, the driving distance between Cusco to Santiago is 2878 km. It takes approximately 35h 33m to drive from Cusco to Santiago.

Get driving directions

LATAM Chile offers flights from Cuzco Airport to Santiago Airport.

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There are 586+ hotels available in Santiago. Prices start at $100 USD per night.

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The best way to get from Cusco to Cuzco Airport is to taxi which takes 5 min and costs $6 - $8.

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