• Our partners include:

  • Booking.com
  • Skyscanner
  • Airbnb
  • Expedia
  • Uber
  • Rentalcars.com

There are 5 ways to get from Cusco to Santiago by plane, train, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  4 h 10 min

  1. Fly from Cuzco (CUZ) to Santiago (SCL) CUZ - SCL

$193 - $848

4 alternative options

Train, bus  •  40 h 49 min

  1. Take the train from Cusco - Wanchaq to Puno
  2. Take the bus from Puno to Tacna
  3. Take the bus from Tacna to Santiago

Tour, bus  •  41 h 30 min

  1. Take the Tour from Cusco to Arequipa Cusco
  2. Take the bus from Arequipa to Santiago Via Cucuta

Bus  •  47 h 19 min

  1. Take the bus from Cusco to Puno
  2. Take the bus from Puno to Tacna
  3. Take the bus from Tacna to Arica
  4. Take the bus from Arica to Santiago - San Borja

Drive  •  36 h 28 min

  1. Drive from Cusco to Santiago 1809 miles

$300 - $440

Questions & Answers

The cheapest way to get from Cusco to Santiago is to fly which costs $190 - $850 and takes 4 h 10 min.

More details

The quickest way to get from Cusco to Santiago is to fly which costs $190 - $850 and takes 4 h 10 min.

More details

No, there is no direct bus from Cusco to Santiago. However, there are services departing from Cusco and arriving at Santiago via Arequipa. The journey, including transfers, takes approximately 41 h 30 min.

More details

The distance between Cusco and Santiago is 2221 km. The road distance is 2894.3 km.

Get driving directions

The best way to get from Cusco to Santiago without a car is to train and bus which takes 40 h 49 min and costs .

More details

It takes approximately 4 h 10 min to get from Cusco to Santiago, including transfers.

More details

Cusco to Santiago bus services, operated by Peru Hop, depart from Cusco station.

More details

The best way to get from Cusco to Santiago is to fly which takes 4 h 10 min and costs $190 - $850. Alternatively, you can Tour and bus, which costs and takes 41 h 30 min.

Mode details

The quickest flight from Cuzco Airport to Santiago Airport is the direct flight which takes 3 h 25 min.

Search flights

Cusco to Santiago bus services, operated by Skybus, arrive at Santiago station.

More details

Map of how to get from Cusco to Santiago.
Launch map view
  • Distance: 1387.9 miles
  • Duration: 4 h 10 min

What companies run services between Cusco, Peru and Santiago, Chile?

LATAM Chile and Avianca - Aerovías del Continente Americano S.A. fly from Cusco to Santiago hourly. Alternatively, you can take a bus from Cusco to Santiago via Arequipa in around 41 h 30 min.

Airlines
LATAM Chile
Website
latam.com
Flights from Cuzco to Santiago
Ave. Duration
3 h 25 min
When
Tuesday, Wednesday and Friday
Estimated price
$360 - $950
Flights from Cuzco to Santiago via Lima
Ave. Duration
6 h 12 min
When
Every day
Estimated price
$360 - $950
Avianca - Aerovías del Continente Americano S.A.
Website
avianca.com
Flights from Cuzco to Santiago via Lima
Ave. Duration
6 h 23 min
When
Every day
Estimated price
$220 - $1,300
Train operators
PeruRail
Phone
51-84-581414
Email
reservas@perurail.com
Website
perurail.com
Train from Cusco - Wanchaq to Puno
Ave. Duration
10 h 19 min
Frequency
4 times a week
Estimated price
$210 - $3,100
Schedules at
perurail.com
Book at
pax1.perurail.com
VIP
$210 - $3,100
Regular
$330 - $460
Bus operators
Peru Hop
Phone
+51 1 2422140
Email
info@peruhop.com
Bus from Cusco to Arequipa
Ave. Duration
10 h 30 min
Frequency
Once daily
Estimated price
$85 - $120
Schedules at
peruhop.com
Book at
peruhop.com
Bus from Cusco to Puno
Ave. Duration
8 h
Frequency
Every 4 hours
Estimated price
$65 - $95
Schedules at
peruhop.com
Book at
peruhop.com
Skybus
Phone
+58 414 8448807
Website
facebook.com
Bus from Arequipa to Santiago
Ave. Duration
30 h
Frequency
Once daily
Schedules at
facebook.com
Chasquitur
Phone
+56 58 231967
Website
terminaldebuses.com
Bus from Tacna to Arica
Ave. Duration
1 h
Frequency
Hourly
Estimated price
$3
Schedules at
bus-america.com
Adsubliata
Phone
+56 58 262 495
Website
terminaldebuses.com
Bus from Tacna to Arica
Ave. Duration
3 h 1 min
Frequency
Hourly
Estimated price
$6
Schedules at
terminaldebuses.com
Buses Norte Grande
Phone
+56 58 222 8603
Email
busesnortegrande_zarzuri@hotmail.com
Website
busesng.cl
Bus from Tacna to Arica
Ave. Duration
3 h 1 min
Frequency
Hourly
Estimated price
$3
Schedules at
busesng.cl
Book at
busesng.cl
Expreso Norte
Fichtur VIP
Phone
+56 (02) 7205232
Website
fichtur.cl
Bus from Arica to Santiago
Ave. Duration
27 h 20 min
Frequency
3 times a day
Estimated price
$50
Schedules at
viajaenbus.cl
Pullman Bus
Phone
600 320 3200
Website
pullman.cl
Bus from Arica to Santiago
Ave. Duration
26 h 20 min
Frequency
Twice daily
Estimated price
$65 - $90
Schedules at
pullman.cl

Want to know more about travelling around the world?

Rome2rio's Travel Guide series provide vital information for the global traveller. Read our range of informative guides on popular transport routes and companies - including What documents do I need to cross Niagara Falls?, Travelling to and around Russia for the 2018 FIFA World Cup and Travelling around the UAE - to help you get the most out of your next trip.

More Questions & Answers

Santiago is 1 h ahead of Cusco. It is currently 11:50 AM in Cusco and 1:50 PM in Santiago.

Yes, the driving distance between Cusco to Santiago is 2894 km. It takes approximately 36 h 28 min to drive from Cusco to Santiago.

Get driving directions

Avianca - Aerovías del Continente Americano S.A. and LATAM Chile offer flights from Cuzco Airport to Santiago Airport.

Search flights

There are 2159+ hotels available in Santiago. Prices start at $44 USD per night.

More details

The best way to get from Cusco to Cuzco Airport is to taxi which takes 5 min and costs $2 - $4.

More details