There are 4 ways to get from Cusco to Santiago by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  4 h 7 min

  1. Fly from Cuzco (CUZ) to Santiago (SCL) CUZ - SCL

$187 - $808

Cheapest option

Bus  •  38 h 4 min

  1. Take the bus from Cusco to Arequipa
  2. Take the bus from Arequipa to Tacna
  3. Take the bus from Tacna to Santiago

$104 - $202

2 alternative options

Train, bus  •  42 h 19 min

  1. Take the train from Cusco - Wanchaq to Puno
  2. Take the bus from Puno to Tacna
  3. Take the bus from Tacna to Santiago

Drive  •  36 h 28 min

  1. Drive from Cusco to Santiago 1809 miles

$300 - $440

Questions & Answers

The cheapest way to get from Cusco to Santiago is to bus which costs $100 - $210 and takes 38 h 4 min.

More details

The quickest way to get from Cusco to Santiago is to fly which costs $180 - $850 and takes 4 h 7 min.

More details

The distance between Cusco and Santiago is 2221 km. The road distance is 2894.3 km.

Get driving directions

It takes approximately 4 h 7 min to get from Cusco to Santiago, including transfers.

More details

No, there is no direct bus from Cusco to Santiago. However, there are services departing from Cusco and arriving at Santiago via Arequipa and Tacna. The journey, including transfers, takes approximately 38 h 4 min.

More details

Map of how to get from Cusco to Santiago.
Launch map view
  • Distance: 1387.9 miles
  • Duration: 4 h 7 min

What companies run services between Cusco, Peru and Santiago, Chile?

LATAM Chile and Avianca - Aerovías del Continente Americano S.A. fly from Cusco to Santiago hourly. Alternatively, you can take a bus from Cusco to Santiago via Arequipa and Tacna in around 38 h 4 min.

Airlines
LATAM Chile
Website
latam.com
Flights from Cuzco to Santiago
Ave. Duration
3 h 25 min
When
Tuesday, Wednesday and Saturday
Estimated price
$360 - $950
Flights from Cuzco to Santiago via Lima
Ave. Duration
6 h
When
Every day
Estimated price
$360 - $950
Avianca - Aerovías del Continente Americano S.A.
Website
avianca.com
Flights from Cuzco to Santiago via Lima
Ave. Duration
6 h 23 min
When
Every day
Estimated price
$220 - $1,300
Train operators
PeruRail
Phone
51-84-581414
Email
reservas@perurail.com
Website
perurail.com
Train from Cusco - Wanchaq to Puno
Ave. Duration
10 h 19 min
Frequency
4 times a week
Estimated price
$200 - $3,100
Schedules at
perurail.com
Book at
pax1.perurail.com
VIP
$210 - $3,100
Regular
$330 - $460
Bus operators
Oltursa
Website
oltursa.pe
Bus from Cusco to Arequipa
Ave. Duration
10 h 15 min
Frequency
Twice daily
Estimated price
$14 - $35
Schedules at
oltursa.pe
Bus from Arequipa to Tacna
Ave. Duration
5 h 15 min
Frequency
Once daily
Estimated price
$10 - $26
Schedules at
oltursa.pe
Book at
oltursa.pe
Movil Tours
Phone
716-8000
Email
info@moviltours.com.pe
Website
moviltours.com.pe
Bus from Cusco to Arequipa
Ave. Duration
10 h
Frequency
Once daily
Estimated price
$18 - $60
Schedules at
moviltours.com.pe
Economy
$21 - $35
Regular
$28 - $40
Suite
$40 - $60
Transzela

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