There are 8 ways to get from Comiso to Madrid by plane, train (Trenitalia, Renfe), train, ferry, bus, car, car ferry, or night train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Vincenzo Magliocco Airport
best- Fly from Vincenzo Magliocco Airport (CIY) to Adolfo Suárez Madrid–Barajas Airport (MAD)CIY - MAD
5h 18m€73–255Train
- Take the train from Comiso to SiracusaRe
- Take the train from Siracusa to Roma TerminiIc
- Take the train from Roma Termini to Marseille St Charles
- Take the train from Marseille St Charles to Madrid-Puerta de Atocha-Almudena Grandes
40h 55m€184–313Train, ferry
- Take the train from Comiso to Caltanissetta Xirbi
- Take the train from Caltanissetta Xirbi to Termini Imerese
- Take the ferry from Port of Palermo Termini Imerese to Port of Civitavecchia
- Take the ferry from Port of Civitavecchia to Port de Barcelona
- Take the train from Barcelona-Sants to Madrid-Puerta de Atocha-Almudena GrandesAve
41h 41m€149–347Bus
- Take the bus from Comiso to Palermo
- Take the bus from Palermo Terminal Bus to Napoli, Autostazione Metropark
- Take the bus from Naples - Bus Station to Perpignan - Bus Station
- Take the bus from Perpignan - Bus Station to Madrid - South Station
2d 1hBus to Catania–Fontanarossa Airport, fly
- Take the bus from Gela Bus Station to Catania Fontanarossa Airport Bus Stop
- Fly from Catania–Fontanarossa Airport (CTA) to Adolfo Suárez Madrid–Barajas Airport (MAD)CTA - MAD
8h 16m€73–217Drive, car ferry
- Drive from Comiso to Port of Palermo
- Take the car ferry from Port of Palermo to Port of Tunis
- Drive from Port of Tunis to Oran
- Take the car ferry from Oran to Alicante
- Drive from Alicante to Madrid
44h 7m€304–525Bus via Milan
- Take the bus from Ragusa Bus Terminal to Catania Via Archimede
- Take the bus from Catania to Milano, Autostazione Lampugnano
- Take the bus from Milano, Autostazione Lampugnano to Madrid Mendez Alvaro Estacion Sur
2d 3h€127–289Train, night train
- Take the train from Comiso to SiracusaRe
- Take the night train from Siracusa to Genova P.Za PrincipeIni
- Take the train from Genova P.Za Principe to Marseille St Charles
- Take the train from Marseille St Charles to Madrid-Puerta de Atocha-Almudena Grandes
41h 5m€249–348
Comiso to Madrid by train
Questions & Answers
The cheapest way to get from Comiso to Madrid is to bus and fly which costs €70 - €220 and takes 8h 16m.
The fastest way to get from Comiso to Madrid is to fly which takes 5h 18m and costs €70 - €260.
No, there is no direct bus from Comiso to Madrid station. However, there are services departing from Comiso and arriving at Madrid - South Station via Palermo Terminal Bus, Naples - Bus Station and Perpignan - Bus Station. The journey, including transfers, takes approximately 2 days 1h.
No, there is no direct train from Comiso to Madrid. However, there are services departing from Comiso and arriving at Madrid-Puerta de Atocha-Almudena Grandes via Siracusa, Roma Termini and Marseille St Charles. The journey, including transfers, takes approximately 40h 55m.
The distance between Comiso and Madrid is 1638 km.
The best way to get from Comiso to Madrid without a car is to train which takes 40h 55m and costs €180 - €320.
It takes approximately 5h 18m to get from Comiso to Madrid, including transfers.
Comiso to Madrid bus services, operated by Azienda Siciliana Trasporti, depart from Comiso station.
Comiso to Madrid train services, operated by Trenitalia S.p.A., depart from Comiso station.
The best way to get from Comiso to Madrid is to fly which takes 5h 18m and costs €70 - €260. Alternatively, you can train, which costs €180 - €320 and takes 40h 55m, you could also bus, which costs and takes 2 days 1h.
What companies run services between Comiso, Italy and Madrid, Spain?
Transavia France, Ulendo Airlink, and four other airlines fly from Vincenzo Magliocco Airport (CIY) to Adolfo Suárez Madrid–Barajas Airport (MAD) once daily. Alternatively, you can take a train from Comiso to Madrid-Puerta de Atocha-Almudena Grandes via Siracusa, Roma Termini, and Marseille St Charles in around 40h 55m.
- Website
- ryanair.com
Flights from Vincenzo Magliocco Airport to Adolfo Suárez Madrid–Barajas Airport via Rome
- Ave. Duration
- 4h 45m
- When
- Wednesday, Friday, and Saturday
- Estimated price
- €70–250
Flights from Catania–Fontanarossa Airport to Adolfo Suárez Madrid–Barajas Airport
- Ave. Duration
- 3h
- When
- Tuesday, Thursday, Saturday, and Sunday
- Estimated price
- €55–200
Flights from Catania–Fontanarossa Airport to Adolfo Suárez Madrid–Barajas Airport via Malta
- Ave. Duration
- 5h 10m
- When
- Friday
- Estimated price
- €55–200
- Website
- iberia.com
Flights from Catania–Fontanarossa Airport to Adolfo Suárez Madrid–Barajas Airport
- Ave. Duration
- 3h 10m
- When
- Wednesday and Sunday
- Estimated price
- €65–170
Flights from Catania–Fontanarossa Airport to Adolfo Suárez Madrid–Barajas Airport via Barcelona
- Ave. Duration
- 5h 50m
- When
- Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €45–190
- Website
- transavia.com
Flights from Vincenzo Magliocco Airport to Adolfo Suárez Madrid–Barajas Airport via Paris Orly
- Ave. Duration
- 8h 10m
- When
- Saturday
- Estimated price
- €110–500
- Website
- flyulendo.com
Flights from Vincenzo Magliocco Airport to Adolfo Suárez Madrid–Barajas Airport via Tirana
- Ave. Duration
- 9h 30m
- When
- Monday and Friday
- Estimated price
- €60–240
- Website
- ita-airways.com
Flights from Vincenzo Magliocco Airport to Adolfo Suárez Madrid–Barajas Airport via Rome
- Ave. Duration
- 5h 9m
- When
- Monday, Wednesday, Friday, and Sunday
- Estimated price
- €85–290
- Website
- vueling.com
Flights from Catania–Fontanarossa Airport to Adolfo Suárez Madrid–Barajas Airport via Barcelona
- Ave. Duration
- 5h 50m
- When
- Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €45–190
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Comiso to Siracusa
- Ave. Duration
- 2h 46m
- Frequency
- 3 times a day
- Estimated price
- €9–14
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Marseille St Charles
- Ave. Duration
- 16h 12m
- Frequency
- Once a week
- Estimated price
- €45–70
- Website
- https://www.trenitalia.com/en.html
Train from Comiso to Caltanissetta Xirbi
- Ave. Duration
- 2h 17m
- Frequency
- 3 times a day
- Estimated price
- €10–15
- Website
- https://www.trenitalia.com/en.html
Train from Caltanissetta Xirbi to Termini Imerese
- Ave. Duration
- 1h 1m
- Frequency
- Every 2 hours
- Estimated price
- €6–10
- Website
- https://www.trenitalia.com/en.html
Train from Genova P.Za Principe to Marseille St Charles
- Ave. Duration
- 7h 16m
- Frequency
- Once a week
- Estimated price
- €55–65
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Siracusa to Roma Termini
- Ave. Duration
- 11h 9m
- Frequency
- Once daily
- Estimated price
- €40–100
- Website
- https://www.trenitalia.com/en.html
Rome2Rio's guide to Renfe Viajeros
Contact Details
- Phone
- +34 91 232 03 20
- Website
- renfe.com
Train from Marseille St Charles to Madrid-Puerta de Atocha-Almudena Grandes
- Ave. Duration
- 7h 48m
- Frequency
- Once daily
- Estimated price
- €90–130
- Website
- https://www.renfe.com/es/en
Train from Barcelona-Sants to Madrid-Puerta de Atocha-Almudena Grandes
- Ave. Duration
- 3h 2m
- Frequency
- Twice daily
- Estimated price
- €45–65
- Website
- https://www.renfe.com/es/en
Rome2Rio's guide to Renfe AVE
Contact Details
- Phone
- +34 91 232 03 20
- Website
- renfe.com
Train from Barcelona-Sants to Madrid-Puerta de Atocha-Almudena Grandes
- Ave. Duration
- 2h 37m
- Frequency
- Hourly
- Estimated price
- €55–160
- Website
- https://www.renfe.com/es/en
- Phone
- +34 900 926 851
- atencion.cliente@iryo.eu
- Website
- iryo.eu
Train from Barcelona-Sants to Madrid-Puerta de Atocha-Almudena Grandes
- Ave. Duration
- 2h 59m
- Frequency
- Hourly
- Estimated price
- €45–140
- Website
- https://iryo.eu/en/home
- Phone
- +34 910 780 990
- Website
- ouigo.com
Train from Barcelona-Sants to Madrid-Puerta de Atocha-Almudena Grandes
- Ave. Duration
- 2h 52m
- Frequency
- Every 4 hours
- Estimated price
- €35–90
- Website
- https://www.ouigo.com/es/en
- Phone
- 06 3000
- Website
- trenitalia.com
Night train from Siracusa to Genova P.Za Principe
- Ave. Duration
- 20h 15m
- Frequency
- Once a week
- Estimated price
- €95–140
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 091 62.08.111
- info@astsicilia.it
- Website
- aziendasicilianatrasporti.it
Bus from Comiso to Palermo
- Ave. Duration
- 3h 35m
- Frequency
- 3 times a day
- Schedules at
- aziendasicilianatrasporti.it
- Phone
- +39 06 88 93 82 32
- Website
- itabus.it
Bus from Palermo Terminal Bus to Napoli, Autostazione Metropark
- Ave. Duration
- 10h 40m
- Frequency
- 3 times a week
- Estimated price
- €19–27
- Website
- https://www.itabus.it/en/home
Bus from Catania to Milano, Autostazione Lampugnano
- Ave. Duration
- 19h 45m
- Frequency
- Twice daily
- Estimated price
- €50–180
- Website
- https://www.itabus.it/en/home
- Website
- blablacar.co.uk
Bus from Naples - Bus Station to Perpignan - Bus Station
- Ave. Duration
- 20h 50m
- Frequency
- Twice daily
- Schedules at
- blablacar.co.uk
Bus from Perpignan - Bus Station to Madrid - South Station
- Ave. Duration
- 11h 50m
- Frequency
- 3 times a day
- Schedules at
- blablacar.co.uk
- Phone
- +34 910 207 007
- alsa@alsa.es
- Website
- alsa.com
Bus from Perpignan - Bus Station to Madrid - South Station
- Ave. Duration
- 12h 30m
- Frequency
- Once daily
- Estimated price
- €75–120
- Website
- https://www.alsa.com/en/
- Phone
- +39 06 164160
- info@etnatrasporti.it
- Website
- etnatrasporti.it
Bus from Gela Bus Station to Catania Fontanarossa Airport Bus Stop
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €6–8
- Schedules at
- etnatrasporti.it
- Phone
- +39 0935 22 460
- Website
- interbus.it
Bus from Ragusa Bus Terminal to Catania Via Archimede
- Ave. Duration
- 2h
- Frequency
- Every 2 hours
- Estimated price
- €6–9
- Schedules at
- interbus.it
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Catania to Milano, Autostazione Lampugnano
- Ave. Duration
- 19h
- Frequency
- Twice daily
- Estimated price
- €60–150
- Website
- https://www.flixbus.co.uk
- Phone
- 07001 8282
- booking@union-ivkoni.com
- Website
- union-ivkoni.com
Bus from Milano, Autostazione Lampugnano to Madrid Mendez Alvaro Estacion Sur
- Ave. Duration
- 26h 30m
- Frequency
- Twice a week
- Estimated price
- €70–100
- Website
- https://union-ivkoni.com/en
- Phone
- +39 010 209 4591
- booking@gnv.it
- Website
- gnv.it
Ferry from Port of Palermo Termini Imerese to Port of Civitavecchia
- Ave. Duration
- 12h
- Frequency
- Twice a week
- Estimated price
- €50–65
- Website
- https://www.gnv.it/en
Car ferry from Port of Palermo to Port of Tunis
- Ave. Duration
- 10h 30m
- Frequency
- Once a week
- Estimated price
- €40–180
- Website
- https://www.gnv.it/en
- Phone
- +39.081.496.444
- info@grimaldi.napoli.it
- Website
- grimaldi-lines.com
Ferry from Port of Civitavecchia to Port de Barcelona
- Ave. Duration
- 20h
- Frequency
- 5 times a week
- Estimated price
- €45–95
- Website
- https://www.grimaldi-lines.com/en/
- Phone
- +213 (0)21 64 43 77 / 78
- contact@algerieferries.dz
- Website
- algerieferries.dz
Car ferry from Oran to Alicante
- Ave. Duration
- 12h
- Frequency
- Once a week
- Estimated price
- €101–102
- Schedules at
- algerieferries.dz
Want to know more about travelling around Spain
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Italy Travel Guides
Read the travel guide
5 delightfully under-the-radar French towns you need to visit
Read the travel guide
Train travel in Spain: A guide to Renfe
Read the travel guide
More Questions & Answers
Comiso to Madrid bus services, operated by Azienda Siciliana Trasporti, arrive at Palermo station.
Comiso to Madrid train services, operated by Trenitalia S.p.A., arrive at Siracusa station.
There are 6907+ hotels available in Madrid.





















































