There are 11 ways to get from Comiso to Karlsruhe by plane, train, train (Trenitalia), car, car ferry, bus, or night train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Vincenzo Magliocco Airport to Stuttgart Airport, train
best- Fly from Vincenzo Magliocco Airport (CIY) to Stuttgart Airport (STR)CIY - STR
- Take the train from Stuttgart Hbf to Karlsruhe Hbf
8h€101–360Bus
cheapest- Take the bus from Ragusa Bus Terminal to Catania Via Archimede
- Take the bus from Catania to Milano, Autostazione Lampugnano
- Take the bus from Milano, Autostazione Lampugnano to Karlsruhe central train stationN07 / ...
31h 50m€86–249Train
- Take the train from Comiso to SiracusaRe
- Take the train from Siracusa to Napoli CentraleIc
- Take the train from Napoli Centrale to Milano Centrale
- Take the train from Milano Centrale to Karlsruhe HbfEc
25h 5m€204–408Drive, car ferry
- Drive from Comiso to Port of Palermo
- Take the car ferry from Port of Palermo to Port of Genoa
- Drive from Port of Genoa to Karlsruhe
30h 21m€194–309Bus to Catania–Fontanarossa Airport, fly to Stuttgart Airport, train
- Take the bus from Gela Bus Station to Catania Fontanarossa Airport Bus Stop
- Fly from Catania–Fontanarossa Airport (CTA) to Stuttgart Airport (STR)CTA - STR
- Take the train from Stuttgart Hbf to Karlsruhe Hbf
8h 50m€111–322Fly Vincenzo Magliocco Airport to Frankfurt, train
- Fly from Vincenzo Magliocco Airport (CIY) to Frankfurt (FRA)CIY - FRA
- Take the train from Frankfurt to Karlsruhe Hauptbahnhof
6h 7m€128–492Fly Vincenzo Magliocco Airport to Milan Linate Airport, train
- Fly from Vincenzo Magliocco Airport (CIY) to Milan Linate Airport (LIN)CIY - LIN
- Take the train from Monza to Karlsruhe Hbf
9h 54m€183–527Bus to Catania–Fontanarossa Airport, fly to Frankfurt, train
- Take the bus from Gela Bus Station to Catania Fontanarossa Airport Bus Stop
- Fly from Catania–Fontanarossa Airport (CTA) to Frankfurt (FRA)CTA - FRA
- Take the train from Frankfurt to Karlsruhe Hauptbahnhof
9h 26m€123–334Train via Rome
- Take the train from Comiso to SiracusaRe
- Take the train from Siracusa to Roma TerminiIc
- Take the train from Roma Termini to Milano CentraleFr / ...
- Take the train from Milano Centrale to Karlsruhe HbfEc
25h 31m€199–403Bus via Palermo
- Take the bus from Comiso to Palermo
- Take the bus from Palermo Via Tommaso Fazello to Milano, San Donato M3
- Take the bus from Milan to Karlsruhe Central Bus Station
35h 15mTrain, night train
- Take the train from Comiso to SiracusaRe
- Take the night train from Siracusa to Milano CentraleIni
- Take the train from Milano Centrale to Karlsruhe HbfEc
31h 40m€219–323
Comiso to Karlsruhe by train
Questions & Answers
The cheapest way to get from Comiso to Karlsruhe is to bus which costs €85 - €250 and takes 31h 50m.
The fastest way to get from Comiso to Karlsruhe is to fly and train which takes 6h 7m and costs €120 - €500.
No, there is no direct bus from Comiso to Karlsruhe station. However, there are services departing from Comiso and arriving at Karlsruhe central train station via Ragusa Bus Terminal, Catania and Milano, Autostazione Lampugnano. The journey, including transfers, takes approximately 31h 50m.
No, there is no direct train from Comiso to Karlsruhe. However, there are services departing from Comiso and arriving at Karlsruhe Hbf via Siracusa, Napoli Centrale and Milano Centrale. The journey, including transfers, takes approximately 25h 5m.
The distance between Comiso and Karlsruhe is 1478 km.
The best way to get from Comiso to Karlsruhe without a car is to train which takes 25h 5m and costs €200 - €410.
It takes approximately 8h to get from Comiso to Karlsruhe, including transfers.
Comiso to Karlsruhe bus services, operated by Interbus, depart from Ragusa Bus Terminal station.
Comiso to Karlsruhe train services, operated by Trenitalia S.p.A., depart from Comiso station.
The best way to get from Comiso to Karlsruhe is to train which takes 25h 5m and costs €200 - €410. Alternatively, you can bus, which costs €85 - €250 and takes 31h 50m.
What companies run services between Comiso, Italy and Karlsruhe, Germany?
You can take a train from Comiso to Karlsruhe Hbf via Siracusa, Napoli Centrale, and Milano Centrale in around 25h 5m. Alternatively, you can take a bus from Comiso to Karlsruhe central train station via Ragusa Bus Terminal, Catania Via Archimede, Catania, and Milano, Autostazione Lampugnano in around 31h 50m.
Transport is disrupted due to the Russia-Ukraine war. Read more
- Website
- ita-airways.com
Flights from Catania–Fontanarossa Airport to Stuttgart Airport via Milan Linate Airport
- Ave. Duration
- 5h 10m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €75–260
Flights from Vincenzo Magliocco Airport to Frankfurt via Milan Linate Airport
- Ave. Duration
- 3h 55m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €170–850
Flights from Vincenzo Magliocco Airport to Frankfurt via Milan Malpensa
- Ave. Duration
- 4h 10m
- When
- Sunday
- Estimated price
- €180–550
Flights from Vincenzo Magliocco Airport to Frankfurt via Rome
- Ave. Duration
- 4h 25m
- When
- Every day
- Estimated price
- €100–410
Flights from Catania–Fontanarossa Airport to Frankfurt
- Ave. Duration
- 2h 35m
- When
- Monday, Saturday, and Sunday
- Estimated price
- €80–310
Flights from Catania–Fontanarossa Airport to Frankfurt via Milan Linate Airport
- Ave. Duration
- 4h 45m
- When
- Every day
- Estimated price
- €65–200
- Website
- lufthansa.com
Flights from Catania–Fontanarossa Airport to Stuttgart Airport via Munich
- Ave. Duration
- 4h 55m
- When
- Friday
- Estimated price
- €95–380
Flights from Vincenzo Magliocco Airport to Frankfurt via Milan Linate Airport
- Ave. Duration
- 3h 55m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €170–850
Flights from Vincenzo Magliocco Airport to Frankfurt via Milan Malpensa
- Ave. Duration
- 4h 10m
- When
- Sunday
- Estimated price
- €180–550
Flights from Vincenzo Magliocco Airport to Frankfurt via Rome
- Ave. Duration
- 4h 25m
- When
- Every day
- Estimated price
- €100–410
Flights from Vincenzo Magliocco Airport to Frankfurt via Tirana
- Ave. Duration
- 6h 30m
- When
- Monday and Friday
- Estimated price
- €110–430
Flights from Catania–Fontanarossa Airport to Frankfurt
- Ave. Duration
- 2h 35m
- When
- Monday, Saturday, and Sunday
- Estimated price
- €80–310
Flights from Catania–Fontanarossa Airport to Frankfurt via Munich
- Ave. Duration
- 4h 30m
- When
- Friday to Sunday
- Estimated price
- €80–320
- Website
- swiss.com
Flights from Catania–Fontanarossa Airport to Stuttgart Airport via Zurich
- Ave. Duration
- 4h 55m
- When
- Monday and Thursday
- Estimated price
- €70–370
Flights from Catania–Fontanarossa Airport to Frankfurt via Zurich
- Ave. Duration
- 4h 20m
- When
- Monday, Thursday, and Friday
- Estimated price
- €60–310
- Website
- aeroitalia.com
Flights from Vincenzo Magliocco Airport to Milan Linate Airport
- Ave. Duration
- 1h 50m
- When
- Every day
- Estimated price
- €35–700
- Website
- flexflight.dk
Flights from Vincenzo Magliocco Airport to Milan Linate Airport
- Ave. Duration
- 1h 50m
- When
- Every day
- Estimated price
- €35–700
- Website
- flyulendo.com
Flights from Vincenzo Magliocco Airport to Stuttgart Airport via Tirana
- Ave. Duration
- 6h 10m
- When
- Monday and Friday
- Estimated price
- €70–310
- Website
- eurowings.com
Flights from Catania–Fontanarossa Airport to Stuttgart Airport
- Ave. Duration
- 2h 20m
- When
- Thursday and Saturday
- Estimated price
- €85–280
- Phone
- +49 711 400 534 44
- service@gabw-bahn.de
- Website
- go-ahead-bw.de
Train from Stuttgart Hbf to Karlsruhe Hbf
- Ave. Duration
- 53 min
- Frequency
- Hourly
- Estimated price
- €14–27
- Schedules at
- go-ahead-bw.de
- 2nd Class Ticket
- €14–18
- 1st Class Ticket
- €18–27
- Phone
- +49 30 311 682904
- Website
- bahn.de
Train from Stuttgart Hbf to Karlsruhe Hbf
- Ave. Duration
- 54 min
- Frequency
- Hourly
- Estimated price
- €18–27
- Website
- https://int.bahn.de/en
Train from Frankfurt to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 8m
- Frequency
- Every 2 hours
- Estimated price
- €18–50
- Website
- https://int.bahn.de/en
- Phone
- +49 7821 9960770
- info@sweg.de
- Website
- sweg.de
Train from Stuttgart Hbf to Karlsruhe Hbf
- Ave. Duration
- 1h 28m
- Frequency
- Twice daily
- Schedules at
- sweg.de
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Comiso to Siracusa
- Ave. Duration
- 2h 46m
- Frequency
- 3 times a day
- Estimated price
- €9–14
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Siracusa to Napoli Centrale
- Ave. Duration
- 8h 48m
- Frequency
- Once daily
- Estimated price
- €35–85
- Website
- https://www.trenitalia.com/en.html
Train from Siracusa to Roma Termini
- Ave. Duration
- 11h 9m
- Frequency
- Once daily
- Estimated price
- €40–100
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Milano Centrale
- Ave. Duration
- 7h 25m
- Frequency
- Once a week
- Estimated price
- €40–75
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Napoli Centrale to Milano Centrale
- Ave. Duration
- 4h 35m
- Frequency
- Hourly
- Estimated price
- €50–140
- Website
- https://www.italotreno.it/en
Train from Roma Termini to Milano Centrale
- Ave. Duration
- 3h 40m
- Frequency
- Hourly
- Estimated price
- €45–120
- Website
- https://www.italotreno.it/en
- Phone
- +39 06 68475475
- ufficiogruppi@trenitalia.it
- Website
- trenitalia.com
Train from Milano Centrale to Karlsruhe Hbf
- Ave. Duration
- 6h 19m
- Frequency
- Once daily
- Estimated price
- €110–170
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €110–170
- 2nd Class
- €110–150
Train from Monza to Karlsruhe Hbf
- Ave. Duration
- 6h 6m
- Frequency
- Once daily
- Estimated price
- €110–170
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €110–170
- 2nd Class
- €110–150
- Phone
- +31 30 751 5155
- Website
- ns.nl
Train from Frankfurt to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 53m
- Frequency
- Twice daily
- Estimated price
- €21–70
- Website
- https://www.ns.nl/en
- 2nd Class
- €21–35
- 1st Class
- €40–70
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Roma Termini to Milano Centrale
- Ave. Duration
- 3h 8m
- Frequency
- Every 30 minutes
- Estimated price
- €50–110
- Schedules at
- trenitalia.com
- Phone
- 06 3000
- Website
- trenitalia.com
Night train from Siracusa to Milano Centrale
- Ave. Duration
- 20h 35m
- Frequency
- 6 times a week
- Estimated price
- €100–140
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 0935 22 460
- Website
- interbus.it
Bus from Ragusa Bus Terminal to Catania Via Archimede
- Ave. Duration
- 2h
- Frequency
- Every 2 hours
- Estimated price
- €6–9
- Schedules at
- interbus.it
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Catania to Milano, Autostazione Lampugnano
- Ave. Duration
- 19h
- Frequency
- Twice daily
- Estimated price
- €55–150
- Website
- https://www.flixbus.co.uk
Bus from Milano, Autostazione Lampugnano to Karlsruhe central train station
- Ave. Duration
- 7h 20m
- Frequency
- Every 4 hours
- Estimated price
- €29–60
- Website
- https://www.flixbus.co.uk
- Phone
- +39 06 88 93 82 32
- Website
- itabus.it
Bus from Catania to Milano, Autostazione Lampugnano
- Ave. Duration
- 19h 45m
- Frequency
- Once daily
- Estimated price
- €50–180
- Website
- https://www.itabus.it/en/home
- Phone
- +3-389-268-0068
- Website
- blablacar.co.uk
Bus from Milano, Autostazione Lampugnano to Karlsruhe central train station
- Ave. Duration
- 9h 40m
- Frequency
- 3 times a week
- Estimated price
- €35–55
- Website
- https://www.blablacar.co.uk/bus
- Phone
- +39 06 164160
- info@etnatrasporti.it
- Website
- etnatrasporti.it
Bus from Gela Bus Station to Catania Fontanarossa Airport Bus Stop
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €6–8
- Schedules at
- etnatrasporti.it
- Phone
- +39 091 62.08.111
- info@astsicilia.it
- Website
- aziendasicilianatrasporti.it
Bus from Comiso to Palermo
- Ave. Duration
- 3h 35m
- Frequency
- 3 times a day
- Schedules at
- aziendasicilianatrasporti.it
- Phone
- (+39) 0923 98.11.20
- Website
- autoservizisalemi.it
Bus from Palermo Via Tommaso Fazello to Milano, San Donato M3
- Ave. Duration
- 19h 10m
- Frequency
- Once a week
- Estimated price
- €50–75
- Schedules at
- autoservizisalemi.it
- Phone
- +39 080 3112335
- info@marinobus.it
- Website
- marinobus.it
Bus from Milan to Karlsruhe Central Bus Station
- Ave. Duration
- 10h 30m
- Frequency
- Twice a week
- Estimated price
- €45–65
- Website
- https://marinobus.it/en/
- Phone
- +39 010 209 4591
- booking@gnv.it
- Website
- gnv.it
Car ferry from Port of Palermo to Port of Genoa
- Ave. Duration
- 20h 45m
- Frequency
- Once daily
- Estimated price
- €60–110
- Website
- https://www.gnv.it/en
Want to know more about travelling around Germany
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Italy Travel Guides
Read the travel guide
Heading to Europe? Read this before you buy a Eurail Pass
Read the travel guide
Want to know more about Flixbus?
Read the travel guide
More Questions & Answers
Comiso to Karlsruhe bus services, operated by Interbus, arrive at Catania Via Archimede station.
Comiso to Karlsruhe train services, operated by Trenitalia S.p.A., arrive at Siracusa station.
Book your Comiso to Karlsruhe train tickets online with Omio.
There are 810+ hotels available in Karlsruhe.








































































