There are 4 ways to get from Columbus to Knoxville by plane, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  4 h 57 min

  1. Fly from Columbus (CMH) to Knoxville (TYS) CMH - TYS

$248 - $1,075

Cheapest option

Bus, Megabus via Nashville, Tn  •  13 h 53 min

  1. Take the bus from Columbus, Oh to Cincinnati, Oh
  2. Take the bus from Cincinnati, Oh to Nashville, Tn
  3. Take the bus from Nashville, TN to Chattanooga
  4. Take the Megabus from Chattanooga to Knoxville

$73 - $160

2 alternative options

Bus, Megabus  •  17 h 25 min

  1. Take the bus from Columbus, Oh to Cincinnati, Oh
  2. Take the bus from Cincinnati, Oh to Atlanta, Ga
  3. Take the Megabus from Atlanta GA to Knoxville

$87 - $196

Drive  •  5 h 57 min

  1. Drive from Columbus to Knoxville 360.2 miles

$35 - $55

What companies run services between Columbus, OH, USA and Knoxville, TN, USA?

Delta, American Airlines and United Airlines fly from Columbus to Knoxville hourly. Alternatively, you can take a bus from Columbus to Knoxville via Cincinnati, Oh, Nashville, Tn, Nashville, TN, and Chattanooga in around 13 h 53 min.

Airlines
American Airlines
Website
aa.com
Flights from Columbus to Knoxville via Charlotte
Ave. Duration
3 h 56 min
When
Every day
Estimated price
$200 - $1,000
Flights from Columbus to Knoxville via Reagan Washington
Ave. Duration
4 h 21 min
When
Monday to Friday
Estimated price
$220 - $1,100
Flights from Columbus to Knoxville via Chicago O'Hare
Ave. Duration
4 h 5 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $1,100
Flights from Columbus to Knoxville via Philadelphia
Ave. Duration
4 h 49 min
When
Every day
Estimated price
$240 - $1,100
Delta
Website
delta.com
Flights from Columbus to Knoxville via Atlanta
Ave. Duration
3 h 59 min
When
Every day
Estimated price
$190 - $1,000
Flights from Columbus to Knoxville via Detroit
Ave. Duration
3 h 52 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $1,000
United Airlines
Website
united.com
Flights from Columbus to Knoxville via Washington Dulles
Ave. Duration
3 h 58 min
When
Every day
Estimated price
$230 - $1,100
Flights from Columbus to Knoxville via Chicago O'Hare
Ave. Duration
4 h 8 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$230 - $1,100
Bus operators
Greyhound USA
Phone
+1 214-849-8100
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Columbus, Oh to Cincinnati, Oh
Ave. Duration
1 h 55 min
Frequency
Hourly
Estimated price
$16 - $40
Website
greyhound.com
Economy
$16 - $25
Flexible
$29 - $40
Bus from Cincinnati, Oh to Nashville, Tn
Ave. Duration
4 h 15 min
Frequency
Hourly
Estimated price
$30 - $75
Website
greyhound.com
Economy
$30 - $50
Flexible
$55 - $75
Bus from Cincinnati, Oh to Atlanta, Ga
Ave. Duration
9 h 55 min
Frequency
Hourly
Estimated price
$45 - $120
Website
greyhound.com
Economy
$45 - $80
Flexible
$90 - $120
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Nashville, TN to Chattanooga
Ave. Duration
2 h 37 min
Frequency
Twice daily
Estimated price
$14 - $25
Schedules at
us.megabus.com
Bus from Chattanooga to Knoxville
Ave. Duration
2 h
Frequency
Twice daily
Estimated price
$12 - $22
Schedules at
us.megabus.com
Bus from Atlanta GA to Knoxville
Ave. Duration
4 h 5 min
Frequency
Twice daily
Estimated price
$22 - $35
Schedules at
us.megabus.com

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Questions & Answers

How far is it from Columbus to Knoxville?

The distance between Columbus and Knoxville is 452 km. The road distance is 576 km.

What is the cheapest way to get from Columbus to Knoxville?

The cheapest way to get from Columbus to Knoxville is to drive which costs $35 - $55 and takes 5 h 57 min.

What is the fastest way to get from Columbus to Knoxville?

The quickest way to get from Columbus to Knoxville is to fly which takes 4 h 57 min and costs $240 - $1,100.

Is there a direct bus between Columbus and Knoxville?

No, there is no direct bus from Columbus to Knoxville. However, there are services departing from Columbus, Oh and arriving at Knoxville via Cincinnati, Oh, Nashville, TN and Chattanooga. The journey, including transfers, takes approximately 13 h 53 min.

How long does it take to get from Columbus to Knoxville?

It takes approximately 4 h 57 min to get from Columbus to Knoxville, including transfers.