There are 4 ways to get from Columbus to Knoxville by bus, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus via Cincinnati, OH  •  7 h 43 min

  1. Take the bus from Columbus, OH to Cincinnati, OH Buffalo
  2. Take the bus from Cincinnati, Oh to Knoxville, Tn 1109 / ...

$45 - $103

3 alternative options

Bus  •  8 h 27 min

  1. Take the bus from Columbus, Oh to Cincinnati, Oh 1537 / ...
  2. Take the bus from Cincinnati, Oh to Knoxville, Tn 1109 / ...

$48 - $118

Drive  •  5 h 57 min

  1. Drive from Columbus to Knoxville 360.2 miles

$35 - $55

Fly  •  4 h 48 min

  1. Fly from Columbus (CMH) to Knoxville (TYS) CMH - TYS

$248 - $1,075

Questions & Answers

No, there is no direct bus from Columbus to Knoxville. However, there are services departing from Columbus, OH and arriving at Knoxville, Tn via Cincinnati, Oh. The journey, including transfers, takes approximately 7 h 43 min.

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The distance between Columbus and Knoxville is 283 miles. The road distance is 360.2 miles.

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The best way to get from Columbus to Knoxville without a car is to bus which takes 7 h 43 min and costs .

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It takes approximately 7 h 43 min to get from Columbus to Knoxville, including transfers.

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Columbus to Knoxville bus services, operated by Greyhound USA, depart from Columbus, Oh station.

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The best way to get from Columbus to Knoxville is to bus which takes 7 h 43 min and costs . Alternatively, you can fly, which costs and takes 4 h 48 min.

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There is no direct flight from Columbus Airport to Knoxville Airport. The quickest flight takes 3 h 20 min and has one stopover.

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Columbus to Knoxville bus services, operated by Greyhound USA, arrive at Knoxville, Tn station.

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Yes, the driving distance between Columbus to Knoxville is 360 miles. It takes approximately 5 h 57 min to drive from Columbus to Knoxville.

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American Airlines, United Airlines and Delta offer flights from Columbus Airport to Knoxville Airport.

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Map of how to get from Columbus to Knoxville.
Launch map view
  • Distance: 282.6 miles
  • Duration: 7 h 43 min

What companies run services between Columbus, OH, USA and Knoxville, TN, USA?

You can take a bus from Columbus to Knoxville via Cincinnati, OH and Cincinnati, Oh in around 7 h 43 min. Alternatively, American Airlines, Delta and United Airlines fly from Columbus to Knoxville hourly.

Airlines
Delta
Website
delta.com
Flights from Columbus to Knoxville via Atlanta
Ave. Duration
4 h
When
Every day
Estimated price
$190 - $1,000
Flights from Columbus to Knoxville via Detroit
Ave. Duration
3 h 49 min
When
Every day
Estimated price
$190 - $1,000
American Airlines
Website
aa.com
Flights from Columbus to Knoxville via Charlotte
Ave. Duration
3 h 51 min
When
Every day
Estimated price
$200 - $1,000
Flights from Columbus to Knoxville via Chicago O'Hare
Ave. Duration
4 h 9 min
When
Every day
Estimated price
$220 - $1,100
Flights from Columbus to Knoxville via Reagan Washington
Ave. Duration
4 h 4 min
When
Every day
Estimated price
$220 - $1,100
United Airlines
Website
united.com
Flights from Columbus to Knoxville via Washington Dulles
Ave. Duration
4 h 2 min
When
Every day
Estimated price
$230 - $1,100
Flights from Columbus to Knoxville via Chicago O'Hare
Ave. Duration
4 h 21 min
When
Monday to Saturday
Estimated price
$230 - $1,100
Flights from Columbus to Knoxville via Newark
Ave. Duration
4 h 41 min
When
Thursday and Sunday
Estimated price
$260 - $1,200
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Cincinnati, Oh to Knoxville, Tn
Ave. Duration
5 h 20 min
Frequency
Every 30 minutes
Estimated price
$29 - $75
Website
greyhound.com
Economy
$29 - $50
Flexible
$55 - $75
Bus from Columbus, Oh to Cincinnati, Oh
Ave. Duration
2 h 55 min
Frequency
Every 30 minutes
Estimated price
$19 - $45
Website
greyhound.com
Economy
$19 - $29
Flexible
$30 - $45

Want to know more about travelling around United States

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Book your Columbus to Knoxville bus tickets online with Greyhound and Greyhound.

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There are 100+ hotels available in Knoxville. Prices start at $56 USD per night.

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The best way to get from Columbus to Columbus Airport is to bus which takes 10 min and costs .

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