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How to get fromCleveland to Saint Charlesby plane, train (Amtrak), bus (Greyhound) or car

Find Transport to Saint Charles

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There are 5 ways to get from Cleveland to Saint Charles by plane, train (Amtrak), bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    4h 19m
    $186–396

  2. Bus

    cheapest
    1. Take the bus from Cleveland Bus Station to Columbusbus bus Greyhound US0105
    2. Take the bus from Columbus to St Louis Bus Stationbus bus Greyhound US0421
    14h 42m
    $61–141

  3. Train (Amtrak)

    1. Take the train from Cleveland Amtrak to Chicago Union Stationtrain train Floridian / ...
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    13h 56m
    $80–243

  4. Drive 567.1 mi

    1. Drive from Cleveland to Saint Charlescar car 567.1 mi
    9h 40m
    $104–150

  5. Bus via Cambridge

    1. Take the bus from Cleveland to Cambridgebus bus Route C SB
    2. Take the bus from Cambridge, OH to St Louis Bus Stationbus bus Greyhound US0421
    15h 44m
    $71–170

Cleveland to Saint Charles by train and bus (Amtrak)

Calendar21Weekly Services
Duration13h 56mAverage Duration
Ticket$80Cheapest Price
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Questions & Answers

What companies run services between Cleveland, OH, USA and Saint Charles, MO, USA?

Southwest Airlines, Delta, and two other airlines fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL) every 2 hours. Alternatively, you can take a train from Cleveland Amtrak to 4375 Rider Trail North Sb via Chicago Union Station, St. Louis, CIVIC CENTER station, NORTH HANLEY station, and North Hanley Transit Center in around 13h 56m.

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