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How to get fromCleveland to Des Moinesby plane, train, bus, bus (Greyhound), or car

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There are 6 ways to get from Cleveland to Des Moines by plane, train, bus, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Cleveland-Hopkins International Airport (CLE) to Des Moines (DSM)plane plane CLE - DSM
    5h 8m
    $180–924

  2. Bus

    cheapest
    1. Take the bus from Cleveland to Chicagobus bus Cleveland
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    15h 5m
    $86–176

  3. Train, bus

    1. Take the train from Cleveland Amtrak to Chicago Union Stationtrain train Floridian / ...
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    14h 25m
    $156–308

  4. Drive 657.8 mi

    1. Drive from Cleveland to Des Moinescar car 657.8 mi
    10h 57m
    $120–174

  5. Train, bus via Toledo

    1. Take the train from Cleveland Amtrak to Toledotrain train
    2. Take the bus from Toledo to Chicago Union Stationbus bus
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    15h 10m
    $168–292

  6. Train, bus via Galesburg

    1. Take the train from Cleveland Amtrak to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    3. Take the bus from Galesburg to Des Moinesbus bus
    16h 17m
    $186–383

Cleveland to Des Moines by train, foot, and bus

Calendar19Weekly Services
Duration14h 25mAverage Duration
Ticket$156Cheapest Price
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Questions & Answers

Map of how to get from Cleveland to Des Moines.ExpandLaunch map view
  • Distance: 629.1 mi
  • Duration: 5h 8m

What companies run services between Cleveland, OH, USA and Des Moines, IA, USA?

Southwest Airlines, Delta, and two other airlines fly from Cleveland-Hopkins International Airport (CLE) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Cleveland to Des Moines via Chicago Bus Station in around 15h 5m.

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