There are 10 ways to get from Clemson to Florida Keys by car, plane, bus (Greyhound), train, bus, taxi, or shuttle
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Drive to Asheville Regional Airport, fly to Key West International Airport
best- Drive from Clemson to Asheville-Airport-AVL
- Fly from Asheville Regional Airport (AVL) to Key West International Airport (EYW)AVL - EYW
6h 34m$140–518Bus
- Take the bus from Anderson, SC to AtlantaNyc
- Take the bus from Atlanta Bus Station to Miami Airport Station
- Take the bus from Miami Airport Station to Big Pine Key
24h$160–341Train, bus
- Take the train from Clemson Amtrak Station to Charlotte Amtrak Station
- Take the train from Charlotte Amtrak Station to Cary
- Take the train from Cary to Miami Amtrak Station
- Take the bus from Miami Airport Station to Big Pine Key
36h 37m$244–459Drive 842.8 mi
- Drive from Clemson to Florida Keys842.8 mi
15h 42m$154–223Taxi to Greenville–Spartanburg International Airport, fly to Key West International Airport
- Take the taxi from Clemson to Greenville–Spartanburg International Airport (GSP)
- Fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW)GSP - EYW
7h 48m$256–798Taxi to Greenville–Spartanburg International Airport, fly to Miami International Airport, shuttle
- Take the taxi from Clemson to Greenville–Spartanburg International Airport (GSP)
- Fly from Greenville–Spartanburg International Airport (GSP) to Miami International Airport (MIA)GSP - MIA
- Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FL
8h 25m$316–743Drive to Asheville Regional Airport, fly to Miami International Airport, shuttle
- Drive from Clemson to Asheville-Airport-AVL
- Fly from Asheville Regional Airport (AVL) to Miami International Airport (MIA)AVL - MIA
- Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FL
9h 9m$205–543Bus to Hartsfield-Jackson Atlanta International Airport, fly to Key West International Airport
- Take the bus from Anderson, SC to Atlanta
- Fly from Hartsfield-Jackson Atlanta International Airport (ATL) to Key West International Airport (EYW)ATL - EYW
8h 50m$183–536Drive to Asheville Regional Airport, fly to Fort Lauderdale–Hollywood International Airport, shuttle
- Drive from Clemson to Asheville-Airport-AVL
- Fly from Asheville Regional Airport (AVL) to Fort Lauderdale–Hollywood International Airport (FLL)AVL - FLL
- Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FL
9h 34m$210–483Train, bus, shuttle
- Take the train from Clemson Amtrak Station to Charlotte Amtrak Station
- Take the bus from Charlotte Bus Station to Orlando Bus Station
- Take the bus from Orlando Bus Station to Fort Lauderdale International Airport
- Take a shuttle bus from Fort Lauderdale, FL - International Airport to Summerland Key - Mote Marine Lab
26h 43m$298–523
Clemson to Florida Keys by train, taxi, bus, and foot
Questions & Answers
The cheapest way to get from Clemson to Florida Keys is to drive which costs $150 - $230 and takes 15h 42m.
The fastest way to get from Clemson to Florida Keys is to drive and fly which takes 6h 34m and costs $140 - $550.
The distance between Clemson and Florida Keys is 851 miles. The road distance is 847.8 miles.
The best way to get from Clemson to Florida Keys without a car is to bus which takes 24h and costs $160 - $350.
It takes approximately 6h 34m to get from Clemson to Florida Keys, including transfers.
Yes, the driving distance between Clemson to Florida Keys is 848 miles. It takes approximately 15h 42m to drive from Clemson to Florida Keys.
There are 824+ hotels available in Florida Keys.
What companies run services between Clemson, SC, USA and Florida Keys, FL, USA?
You can take a vehicle from Clemson to Florida Keys via Anderson, SC, Atlanta, Buford Hwy @ Mcelroy Rd, Doraville Station, Doraville Station, Garnett Station, Atlanta Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 24h.
- Website
- delta.com
Flights from Asheville Regional Airport to Key West International Airport via Hartsfield-Jackson Atlanta International Airport
- Ave. Duration
- 4h 25m
- When
- Every day
- Estimated price
- $85–450
Flights from Greenville–Spartanburg International Airport to Key West International Airport via Hartsfield-Jackson Atlanta International Airport
- Ave. Duration
- 4h 12m
- When
- Every day
- Estimated price
- $110–600
Flights from Greenville–Spartanburg International Airport to Miami International Airport via Hartsfield-Jackson Atlanta International Airport
- Ave. Duration
- 4h 26m
- When
- Every day
- Estimated price
- $85–450
Flights from Asheville Regional Airport to Miami International Airport via Hartsfield-Jackson Atlanta International Airport
- Ave. Duration
- 4h 29m
- When
- Every day
- Estimated price
- $65–360
Flights from Hartsfield-Jackson Atlanta International Airport to Key West International Airport
- Ave. Duration
- 1h 55m
- When
- Every day
- Estimated price
- $65–370
Flights from Asheville Regional Airport to Fort Lauderdale–Hollywood International Airport via Hartsfield-Jackson Atlanta International Airport
- Ave. Duration
- 4h
- When
- Saturday
- Estimated price
- $50–270
- Website
- allegiantair.com
Flights from Asheville Regional Airport to Key West International Airport
- Ave. Duration
- 2h 9m
- When
- Tuesday, Thursday, and Sunday
- Estimated price
- $80–430
Flights from Asheville Regional Airport to Key West International Airport via St. Petersburg
- Ave. Duration
- 4h 12m
- When
- Tuesday, Friday, and Saturday
- Estimated price
- $80–440
Flights from Asheville Regional Airport to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 2h 1m
- When
- Every day
- Estimated price
- $45–260
- Website
- aa.com
Flights from Asheville Regional Airport to Key West International Airport via Charlotte
- Ave. Duration
- 4h 33m
- When
- Every day
- Estimated price
- $85–450
Flights from Asheville Regional Airport to Key West International Airport via Miami International Airport
- Ave. Duration
- 5h 6m
- When
- Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $85–450
Flights from Greenville–Spartanburg International Airport to Key West International Airport via Charlotte
- Ave. Duration
- 5h 28m
- When
- Every day
- Estimated price
- $110–600
Flights from Greenville–Spartanburg International Airport to Key West International Airport via Miami International Airport
- Ave. Duration
- 5h 52m
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $100–600
Flights from Greenville–Spartanburg International Airport to Miami International Airport
- Ave. Duration
- 2h
- When
- Every day
- Estimated price
- $75–430
Flights from Greenville–Spartanburg International Airport to Miami International Airport via Charlotte
- Ave. Duration
- 4h 25m
- When
- Every day
- Estimated price
- $85–450
Flights from Asheville Regional Airport to Miami International Airport
- Ave. Duration
- 2h 6m
- When
- Every day
- Estimated price
- $60–340
Flights from Asheville Regional Airport to Miami International Airport via Charlotte
- Ave. Duration
- 4h 25m
- When
- Every day
- Estimated price
- $65–350
Flights from Hartsfield-Jackson Atlanta International Airport to Key West International Airport via Miami International Airport
- Ave. Duration
- 4h 36m
- When
- Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $70–390
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Clemson Amtrak Station to Charlotte Amtrak Station
- Ave. Duration
- 3h 25m
- Frequency
- Once daily
- Estimated price
- $45–85
- Website
- https://www.amtrak.com/home.html
Train from Charlotte Amtrak Station to Cary
- Ave. Duration
- 3h 1m
- Frequency
- 5 times a day
- Estimated price
- $30–45
- Website
- https://www.amtrak.com/home.html
Train from Cary to Miami Amtrak Station
- Ave. Duration
- 21h 58m
- Frequency
- Once daily
- Estimated price
- $120–260
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 646-630-7186
- help@wandacoach.com
- Website
- wandacoach.com
Bus from Anderson, SC to Atlanta
- Ave. Duration
- 1h 30m
- Frequency
- 3 times a day
- Estimated price
- $35–55
- Website
- https://www.wandacoach.com
- Book at
- https://www.gotobus.com/wanda-travel/
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Atlanta Bus Station to Miami Airport Station
- Ave. Duration
- 14h 5m
- Frequency
- Once daily
- Estimated price
- $65–200
- Website
- https://www.greyhound.com/
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 35m
- Frequency
- 3 times a day
- Estimated price
- $22–40
- Website
- https://www.greyhound.com/
- Phone
- +1 (305) 289-9997
- groups@keysshuttle.com
- Website
- keysshuttle.com
Shuttle from Miami, FL - International Airport to Big Pine Key, FL
- Ave. Duration
- 3h
- Frequency
- 4 times a day
- Estimated price
- $130–180
- Website
- https://www.keysshuttle.com
Shuttle from Fort Lauderdale, FL - International Airport to Big Pine Key, FL
- Ave. Duration
- 3h 30m
- Frequency
- 4 times a day
- Estimated price
- $150–200
- Website
- https://www.keysshuttle.com
Shuttle from Fort Lauderdale, FL - International Airport to Summerland Key - Mote Marine Lab
- Ave. Duration
- 4h
- Frequency
- 4 times a day
- Estimated price
- $150–210
- Website
- https://www.keysshuttle.com
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Charlotte Bus Station to Orlando Bus Station
- Ave. Duration
- 10h 15m
- Frequency
- Twice daily
- Estimated price
- $70–180
- Schedules at
- flixbus.com
Bus from Orlando Bus Station to Fort Lauderdale International Airport
- Ave. Duration
- 4h 5m
- Frequency
- 4 times a day
- Estimated price
- $27–45
- Schedules at
- flixbus.com
- Ave. Duration
- 57 min
- Estimated price
- $100–130
Yellow Cab of Anderson
- Phone
- +1 864-224-3434
Yellow Cab of Anderson
- Phone
- +1 864-224-3434
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide










