There are 10 ways to get from Clemson to Florida Keys by car, plane, taxi, bus, train, or shuttle
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Drive to Asheville Regional Airport, fly to Key West International Airport
best- Drive from Clemson to Asheville-Airport-AVLcar
- Fly from Asheville Regional Airport (AVL) to Key West International Airport (EYW)plane AVL - EYW
6h 35m$150–433Taxi, bus
- Take the taxi from Clemson to Taqueria Guadalajara - Greenvilletaxi
- Take the bus from Taqueria Guadalajara - Greenville to Atlantabus
- Take the bus from Atlanta Bus Station to Miami Airport Stationbus
- Take the bus from Miami Airport Station to Big Pine Keybus
25h 22m$250–493Train, bus
- Take the train from Clemson Amtrak Station to Charlotte Amtrak Stationtrain
- Take the train from Charlotte Amtrak Station to Carytrain
- Take the train from Cary to Miami Amtrak Stationtrain
- Take the bus from Miami Airport Station to Big Pine Keybus
36h 37m$433–919Drive 842.9 mi
- Drive from Clemson to Florida Keyscar 842.9 mi
15h 51m$154–223Taxi to Greenville–Spartanburg International Airport, fly to Key West International Airport
- Take the taxi from Clemson to Greenville–Spartanburg International Airport (GSP)taxi
- Fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW)plane GSP - EYW
7h 42m$275–649Taxi to Greenville–Spartanburg International Airport, fly to Miami International Airport, shuttle
- Take the taxi from Clemson to Greenville–Spartanburg International Airport (GSP)taxi
- Fly from Greenville–Spartanburg International Airport (GSP) to Miami International Airport (MIA)plane GSP - MIA
- Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FL
8h 23m$360–809Taxi to Greenville–Spartanburg International Airport, fly to Fort Lauderdale–Hollywood International Airport, shuttle
- Take the taxi from Clemson to Greenville–Spartanburg International Airport (GSP)taxi
- Fly from Greenville–Spartanburg International Airport (GSP) to Fort Lauderdale–Hollywood International Airport (FLL)plane GSP - FLL
- Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FL
8h 54m$435–1,149Taxi, bus to Hartsfield-Jackson Atlanta International Airport, fly to Key West International Airport
- Take the taxi from Clemson to Flying J - Commercetaxi
- Take the bus from Flying J - Commerce to Atlantabus
- Fly from Hartsfield-Jackson Atlanta International Airport (ATL) to Key West International Airport (EYW)plane ATL - EYW
9h 32m$302–735Drive to Asheville Regional Airport, fly to Fort Lauderdale–Hollywood International Airport, shuttle
- Drive from Clemson to Asheville-Airport-AVLcar
- Fly from Asheville Regional Airport (AVL) to Fort Lauderdale–Hollywood International Airport (FLL)plane AVL - FLL
- Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FL
9h 36m$255–623Train to Charlotte Douglas International Airport, fly to Key West International Airport
- Take the train from Clemson Amtrak Station to Charlotte Amtrak Stationtrain
- Fly from Charlotte Douglas International Airport (CLT) to Key West International Airport (EYW)plane CLT - EYW
10h 40m$201–591
Clemson to Florida Keys by train, taxi, bus, and foot
Questions & Answers
The cheapest way to get from Clemson to Florida Keys is to drive which costs $150 - $230 and takes 15h 51m.
The fastest way to get from Clemson to Florida Keys is to drive and fly which takes 6h 35m and costs $150 - $440.
The distance between Clemson and Florida Keys is 852 miles. The road distance is 847.8 miles.
The best way to get from Clemson to Florida Keys without a car is to taxi and bus which takes 25h 22m and costs $250 - $500.
It takes approximately 6h 35m to get from Clemson to Florida Keys, including transfers.
Yes, the driving distance between Clemson to Florida Keys is 848 miles. It takes approximately 15h 51m to drive from Clemson to Florida Keys.
There are 962+ hotels available in Florida Keys.
What companies run services between Clemson, SC, USA and Florida Keys, FL, USA?
There is no direct connection from Clemson to Florida Keys. However, you can drive to Asheville-Airport-AVL airport, fly to Key West International Airport (EYW), walk to Key West Airport, take the shuttle to Key West, FL, walk to Whitehead & Eaton, take the bus to Sugarloaf Key - Lower - Opposite Sugarloaf Lodge, then walk to Florida Keys. Alternatively, you can take the taxi to Taqueria Guadalajara - Greenville, take the bus to Atlanta, walk to Doraville Station, take the subway to Garnett Station, walk to Atlanta Bus Station, take the bus to Miami Airport Station, take the bus to Big Pine Key, walk to Big Pine Key - CVS / MM30, take the bus to Sugarloaf Key - Lower - Sugarloaf Lodge, then walk to Florida Keys.
- Website
- delta.com
Flights from Asheville Regional Airport to Key West International Airport via Hartsfield-Jackson Atlanta International Airport
- Ave. Duration
- 4h 48m
- When
- Every day
- Estimated price
- $65–330
Flights from Greenville–Spartanburg International Airport to Key West International Airport via Hartsfield-Jackson Atlanta International Airport
- Ave. Duration
- 4h 46m
- When
- Every day
- Estimated price
- $80–420
Flights from Greenville–Spartanburg International Airport to Miami International Airport via Hartsfield-Jackson Atlanta International Airport
- Ave. Duration
- 4h 22m
- When
- Every day
- Estimated price
- $95–550
Flights from Greenville–Spartanburg International Airport to Fort Lauderdale–Hollywood International Airport via Hartsfield-Jackson Atlanta International Airport
- Ave. Duration
- 4h 12m
- When
- Every day
- Estimated price
- $100–550
Flights from Hartsfield-Jackson Atlanta International Airport to Key West International Airport
- Ave. Duration
- 1h 56m
- When
- Every day
- Estimated price
- $65–360
Flights from Asheville Regional Airport to Fort Lauderdale–Hollywood International Airport via Hartsfield-Jackson Atlanta International Airport
- Ave. Duration
- 4h 12m
- When
- Every day
- Estimated price
- $80–420
Flights from Charlotte Douglas International Airport to Key West International Airport via Hartsfield-Jackson Atlanta International Airport
- Ave. Duration
- 4h 52m
- When
- Every day
- Estimated price
- $85–430
- Website
- aa.com
Flights from Asheville Regional Airport to Key West International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 4h 51m
- When
- Every day
- Estimated price
- $65–340
Flights from Asheville Regional Airport to Key West International Airport via Miami International Airport
- Ave. Duration
- 5h 4m
- When
- Every day
- Estimated price
- $60–330
Flights from Greenville–Spartanburg International Airport to Key West International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 5h 6m
- When
- Every day
- Estimated price
- $80–420
Flights from Greenville–Spartanburg International Airport to Key West International Airport via Miami International Airport
- Ave. Duration
- 4h 56m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $75–410
Flights from Greenville–Spartanburg International Airport to Miami International Airport
- Ave. Duration
- 1h 59m
- When
- Every day
- Estimated price
- $85–480
Flights from Greenville–Spartanburg International Airport to Miami International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 4h 30m
- When
- Every day
- Estimated price
- $95–550
Flights from Greenville–Spartanburg International Airport to Fort Lauderdale–Hollywood International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 4h 14m
- When
- Every day
- Estimated price
- $95–550
Flights from Hartsfield-Jackson Atlanta International Airport to Key West International Airport via Miami International Airport
- Ave. Duration
- 4h 5m
- When
- Every day
- Estimated price
- $70–370
Flights from Asheville Regional Airport to Fort Lauderdale–Hollywood International Airport via Charlotte Douglas International Airport
- Ave. Duration
- 4h 17m
- When
- Every day
- Estimated price
- $75–410
Flights from Charlotte Douglas International Airport to Key West International Airport
- Ave. Duration
- 2h 19m
- When
- Every day
- Estimated price
- $75–400
Flights from Charlotte Douglas International Airport to Key West International Airport via Miami International Airport
- Ave. Duration
- 4h 42m
- When
- Every day
- Estimated price
- $75–410
- Website
- allegiantair.com
Flights from Asheville Regional Airport to Key West International Airport
- Ave. Duration
- 2h 10m
- When
- Thursday and Sunday
- Estimated price
- $60–320
Flights from Asheville Regional Airport to Key West International Airport via St. Petersburg
- Ave. Duration
- 4h 4m
- When
- Saturday, Thursday, and Sunday
- Estimated price
- $60–320
Flights from Greenville–Spartanburg International Airport to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 1h 58m
- When
- Monday and Friday
- Estimated price
- $90–490
Flights from Asheville Regional Airport to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 2h 2m
- When
- Every day
- Estimated price
- $70–400
- Website
- flybreeze.com
Flights from Greenville–Spartanburg International Airport to Key West International Airport via Tampa
- Ave. Duration
- 8h 6m
- When
- Thursday and Sunday
- Estimated price
- $150–900
Flights from Greenville–Spartanburg International Airport to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 1h 58m
- When
- Thursday, Sunday, Monday, and Friday
- Estimated price
- $110–800
Flights from Greenville–Spartanburg International Airport to Fort Lauderdale–Hollywood International Airport via Tampa
- Ave. Duration
- 3h 50m
- When
- Monday and Friday
- Estimated price
- $110–800
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Clemson Amtrak Station to Charlotte Amtrak Station
- Ave. Duration
- 3h 25m
- Frequency
- Once daily
- Estimated price
- $40–95
- Website
- Amtrak
Train from Charlotte Amtrak Station to Cary
- Ave. Duration
- 3h 1m
- Frequency
- 5 times a day
- Estimated price
- $50–110
- Website
- Amtrak
Train from Cary to Miami Amtrak Station
- Ave. Duration
- 21h 53m
- Frequency
- Once daily
- Estimated price
- $300–650
- Website
- Amtrak
Train from Clemson Amtrak Station to Charlotte Amtrak Station
- Ave. Duration
- 3h 25m
- Frequency
- Once daily
- Estimated price
- $40–95
- Website
- Amtrak
- Phone
- +1 888 358 6762
- info@tornadobus.com
- Website
- Tornado Bus Company
Bus from Taqueria Guadalajara - Greenville to Atlanta
- Ave. Duration
- 3h 23m
- Frequency
- Once daily
- Estimated price
- $45–150
- Schedules at
- Tornado Bus Company
- Adults 11-59
- $45–150
Bus from Flying J - Commerce to Atlanta
- Ave. Duration
- 1h 53m
- Frequency
- Once daily
- Estimated price
- $40–140
- Schedules at
- Tornado Bus Company
- Adults 11-59
- $40–140
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Atlanta Bus Station to Miami Airport Station
- Ave. Duration
- 13h 30m
- Frequency
- Once daily
- Estimated price
- $100–180
- Schedules at
- Flixbus USA
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- Greyhound
Bus from Atlanta Bus Station to Miami Airport Station
- Ave. Duration
- 17h 20m
- Frequency
- Once daily
- Estimated price
- $100–200
- Website
- Greyhound
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 40m
- Frequency
- 3 times a day
- Estimated price
- $19–40
- Website
- Greyhound
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 40m
- Frequency
- 3 times a day
- Estimated price
- $19–40
- Website
- Greyhound
- Phone
- +1 (305) 289-9997
- groups@keysshuttle.com
- Website
- Keys Shuttle
Shuttle from Miami, FL - International Airport to Big Pine Key, FL
- Ave. Duration
- 3h
- Frequency
- 3 times a day
- Estimated price
- $150–180
- Website
- Keys Shuttle
Shuttle from Fort Lauderdale, FL - International Airport to Big Pine Key, FL
- Ave. Duration
- 3h 30m
- Frequency
- 3 times a day
- Estimated price
- $170–200
- Website
- Keys Shuttle
Shuttle from Fort Lauderdale, FL - International Airport to Big Pine Key, FL
- Ave. Duration
- 3h 30m
- Frequency
- 3 times a day
- Estimated price
- $170–200
- Website
- Keys Shuttle
- Ave. Duration
- 51 min
- Estimated price
- $80–150
Yellow Cab of Anderson
- Phone
- +1 864-224-3434
Yellow Cab of Anderson
- Phone
- +1 864-224-3434
Yellow Cab of Anderson
- Phone
- +1 864-224-3434
Yellow Cab of Anderson
- Phone
- +1 864-224-3434
Yellow Cab of Anderson
- Phone
- +1 864-224-3434
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide











