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How to get fromCincinnati to St. Louisby bus (Greyhound), car, plane, or bus

Find Transport to St. Louis

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There are 5 ways to get from Cincinnati to St. Louis by bus (Greyhound), car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Cincinnati to Indianapolisbus bus Bsb 14 / ...
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421
    9h 5m
    $54–145

  2. Drive  346 mi

    1. Drive from Cincinnati to St. Louiscar car 346 mi
    5h 48m
    $64–92

  3. Fly from Covington

    1. Fly from Covington (CVG) to Lambert–St. Louis International Airport (STL)plane plane CVG - STL
    5h 41m
    $124–754

  4. Drive to Louisville International Airport, fly

    1. Drive from Cincinnati to Louisville-Airport-SDFcar car
    2. Fly from Louisville International Airport (SDF) to Lambert–St. Louis International Airport (STL)plane plane SDF - STL
    5h 53m
    $112–581

  5. Bus to John Glenn Columbus International Airport, fly

    1. Take the bus from Cincinnati to Columbusbus bus
    2. Fly from John Glenn Columbus International Airport (CMH) to Lambert–St. Louis International Airport (STL)plane plane CMH - STL
    6h 33m
    $122–643

Cincinnati to St. Louis by bus

Calendar14Weekly Buses
Duration9h 5mAverage Duration
Ticket$54Cheapest Price
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Comparing Your Travel Options

Map of how to get from Cincinnati to St. Louis.ExpandLaunch map view
  • Distance: 387.1 mi
  • Duration: 9h 5m

What companies run services between Cincinnati, OH, USA and St. Louis, MO, USA?

You can take a bus from Cincinnati to St Louis Bus Station via Cincinnati and Indianapolis Union Station in around 9h 5m. Alternatively, Southwest Airlines, Delta, and two other airlines fly from Covington (CVG) to Lambert–St. Louis International Airport (STL) hourly.

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Bus operators

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