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How to get fromCincinnati to St. Louisby bus (Flixbus, Greyhound), car, plane, bus (Greyhound), or bus

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There are 8 ways to get from Cincinnati to St. Louis by bus (Flixbus, Greyhound), car, plane, bus (Greyhound), or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Dayton

    best
    1. Take the bus from Cincinnati to Dayton Trotwood Bus Stationbus bus
    2. Take the bus from Dayton Trotwood Bus Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus
    8h 35m
    $60–115

  2. Bus

    cheapest
    1. Take the bus from Greyhound Station Cincinnati to Indianapolis, INbus bus Cincinnati
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421
    9h 5m
    $49–150

  3. Drive 346 mi

    1. Drive from Cincinnati to St. Louiscar car 346 mi
    5h 48m
    $64–92

  4. Fly Covington to Lambert–St. Louis International Airport

    1. Fly from Covington (CVG) to Lambert–St. Louis International Airport (STL)plane plane CVG - STL
    5h 36m
    $604–954

  5. Bus via Evansville

    1. Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus bus
    2. Take the bus from Louisville, KY to Evansville, INbus bus
    3. Take the bus from Evansville Bus Station to St Louis Bus Stationbus bus
    9h 30m
    $70–148

  6. Drive to Louisville International Airport, fly to Lambert–St. Louis International Airport

    1. Drive from Cincinnati to Louisville-Airport-SDFcar car
    2. Fly from Louisville International Airport (SDF) to Lambert–St. Louis International Airport (STL)plane plane SDF - STL
    5h 58m
    $117–631

  7. Bus to John Glenn Columbus International Airport, fly to Lambert–St. Louis International Airport

    1. Take the bus from Cincinnati to Columbusbus bus
    2. Fly from John Glenn Columbus International Airport (CMH) to Lambert–St. Louis International Airport (STL)plane plane CMH - STL
    6h 33m
    $833–954

  8. Fly Covington to Midamerica St. Louis Airport

    1. Fly from Covington (CVG) to Midamerica St. Louis Airport (BLV)plane plane CVG - BLV
    10h 17m
    $168–734

Cincinnati to St. Louis by bus

Calendar9Weekly Buses
Duration8h 35mAverage Duration
Ticket$60Cheapest Price
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Questions & Answers

Map of how to get from Cincinnati to St. Louis.ExpandLaunch map view
  • Distance: 403.2 mi
  • Duration: 8h 35m

What companies run services between Cincinnati, OH, USA and St. Louis, MO, USA?

You can take a bus from Cincinnati to St Louis Bus Station via Dayton Trotwood Bus Station and Indianapolis Union Station in around 8h 35m. Alternatively, Southwest Airlines, Delta, and two other airlines fly from Covington (CVG) to Lambert–St. Louis International Airport (STL) hourly.

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