Rome2Rio

How to get fromChicago to Wiseby plane, car, train, bus or taxi

Find Transport to Wise

See all options

There are 11 ways to get from Chicago to Wise by plane, car, train, bus, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago Midway International Airport to Tri-Cities Regional Tn/Va Airport, drive

    best
    1. Fly from Chicago Midway International Airport (MDW) to Tri-Cities Regional Tn/Va Airport (TRI)planeMDW - TRI
    2. Drive from Tri-Cities-Regional-Airport-TRI to Wisecar
    7h
    $92–450

  2. Fly Chicago O'Hare International Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Asheville Regional Airport (AVL)planeORD - AVL
    2. Drive from Asheville-Airport-AVL to Wisecar
    6h 45m
    $82–365

  3. Train, bus, drive

    1. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain
    2. Take the bus from New York City to Johnson CitybusNy
    3. Drive from Johnson City to Wisecar
    33h 45m
    $204–584

  4. Bus, drive

    1. Take the bus from Chicago Bus Station to New York City Chinatownbus
    2. Take the bus from New York City to Johnson CitybusNy
    3. Drive from Johnson City to Wisecar
    33h 51m
    $179–371

  5. Drive 524.7 mi

    1. Drive from Chicago to Wisecar524.7 mi
    9h 43m
    $96–139

  6. Fly Chicago O'Hare International Airport to Mcghee Tyson Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS)planeORD - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Wisecar
    6h 50m
    $112–590

  7. Fly Chicago O'Hare International Airport to Blue Grass Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)planeORD - LEX
    2. Drive from Lexington-Airport-LEX to Wisecar
    6h 54m
    $132–705

  8. Fly Chicago O'Hare International Airport to Yeager Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Yeager Airport (CRW)planeORD - CRW
    2. Drive from Yeager Airport (CRW) to Wisecar
    7h 15m
    $86–380

  9. Fly Chicago O'Hare International Airport to Greenville–Spartanburg International Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP)planeORD - GSP
    2. Drive from Greenville–Spartanburg International Airport (GSP) to Wisecar
    7h 54m
    $282–605

  10. Train, bus, taxi, drive

    1. Take the train from Chicago Union Station to Carytrain
    2. Take the train from Cary to Greensborotrain
    3. Take the bus from Greensboro Bus Stop to Asheville, NCbus
    4. Take the taxi from Asheville, NC to Spivey Gaptaxi
    5. Drive from Uncle Johnny's Erwin to Wisecar
    34h 47m
    $358–1,975

  11. Bus, drive via Baltimore

    1. Take the bus from Chicago Bus Station to Baltimore Downtown Bus Stationbus
    2. Take the bus from Baltimore Downtown Bus Station to Port Authority Bus Terminalbus
    3. Take the bus from New York City to Johnson CitybusNy
    4. Drive from Johnson City to Wisecar
    35h 12m
    $193–391

Chicago Midway International Airport (MDW) to Tri-Cities Regional Tn/Va Airport (TRI) flights

Calendar29Weekly Planes
Duration4h 42mAverage Duration
Ticket$80Cheapest Price
See schedules

Questions & Answers

What companies run services between Chicago, IL, USA and Wise, VA, USA?

There is no direct connection from Chicago to Wise. However, you can take the subway to Midway, walk to Chicago-Midway-Airport-MDW airport, fly to Tri-Cities Regional Tn/Va Airport (TRI), then drive to Wise. Alternatively, you can take a train from Chicago Union Station to Wise via Ny Moynihan Train Hall At Penn Station, 34 St-Herald Sq, East Broadway, New York City, and Johnson City in around 33h 45m.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Trips from Chicago

Trips to Wise

Popular routes