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How to get fromChicago to Wiseby plane, car, train, bus or taxi

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There are 11 ways to get from Chicago to Wise by plane, car, train, bus, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Tri-Cities Regional Tn/Va Airport, drive

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Tri-Cities Regional Tn/Va Airport (TRI)plane plane ORD - TRI
    2. Drive from Tri-Cities-Regional-Airport-TRI to Wisecar car
    5h 13m
    $82–450

  2. Fly Chicago O'Hare International Airport to Blue Grass Airport, drive

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)plane plane ORD - LEX
    2. Drive from Lexington-Airport-LEX to Wisecar car
    6h 54m
    $72–335

  3. Train, bus, drive

    1. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Take the bus from New York City to Johnson Citybus bus Ny
    3. Drive from Johnson City to Wisecar car
    33h 45m
    $202–439

  4. Bus, drive

    1. Take the bus from Chicago Bus Station to New York City Chinatownbus bus
    2. Take the bus from New York City to Johnson Citybus bus Ny
    3. Drive from Johnson City to Wisecar car
    33h 51m
    $177–292

  5. Drive 524.7 mi

    1. Drive from Chicago to Wisecar car 524.7 mi
    9h 47m
    $96–139

  6. Fly Chicago Midway International Airport to Tri-Cities Regional Tn/Va Airport, drive

    1. Fly from Chicago Midway International Airport (MDW) to Tri-Cities Regional Tn/Va Airport (TRI)plane plane MDW - TRI
    2. Drive from Tri-Cities-Regional-Airport-TRI to Wisecar car
    7h 14m
    $122–720

  7. Fly Chicago O'Hare International Airport to Asheville Regional Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Asheville Regional Airport (AVL)plane plane ORD - AVL
    2. Drive from Asheville-Airport-AVL to Wisecar car
    6h 46m
    $76–355

  8. Fly Chicago O'Hare International Airport to Mcghee Tyson Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Mcghee Tyson Airport (TYS)plane plane ORD - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Wisecar car
    6h 51m
    $112–590

  9. Fly Chicago O'Hare International Airport to Yeager Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Yeager Airport (CRW)plane plane ORD - CRW
    2. Drive from Yeager Airport (CRW) to Wisecar car
    7h 15m
    $80–380

  10. Train, bus, taxi, drive

    1. Take the train from Chicago Union Station to Carytrain train
    2. Take the train from Cary to Greensborotrain train
    3. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    4. Take the taxi from Asheville, NC to Spivey Gaptaxi taxi
    5. Drive from Uncle Johnny's Erwin to Wisecar car
    34h 48m
    $304–622

  11. Bus, drive via Baltimore

    1. Take the bus from Chicago Bus Station to Baltimore Downtown Bus Stationbus bus
    2. Take the bus from Baltimore Downtown Bus Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York City to Johnson Citybus bus Ny
    4. Drive from Johnson City to Wisecar car
    35h 12m
    $190–335

Chicago O'Hare International Airport (ORD) to Tri-Cities Regional Tn/Va Airport (TRI) flights

Calendar27Weekly Planes
Duration3h 5mAverage Duration
Ticket$70Cheapest Price
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Questions & Answers

What companies run services between Chicago, IL, USA and Wise, VA, USA?

There is no direct connection from Chicago to Wise. However, you can take the subway to O'Hare, walk to Chicago O'Hare International Airport (ORD) airport, fly to Tri-Cities Regional Tn/Va Airport (TRI), then drive to Wise. Alternatively, you can take a train from Chicago Union Station to Wise via Ny Moynihan Train Hall At Penn Station, 34 St-Herald Sq, East Broadway, New York City, and Johnson City in around 33h 45m.

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