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There are 8 ways to get from Chicago to Southern Illinois University Edwardsville by plane, car, bus or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Chicago Midway to St. Louis  •  3 h 9 min

  1. Fly from Chicago Midway (MDW) to St. Louis (STL) MDW - STL

$197 - $399

Cheapest option

Bus Megabus  •  7 h 50 min

  1. Take the bus from Chicago, IL to St. Louis via St Louis

$69 - $90

6 alternative options

Fly Chicago O'Hare to St. Louis  •  3 h 22 min

  1. Fly from Chicago O'Hare (ORD) to St. Louis (STL) ORD - STL

$162 - $340

Fly Chicago O'Hare to Springfield, drive  •  4 h 12 min

  1. Fly from Chicago O'Hare (ORD) to Springfield (SPI) ORD - SPI
  2. Drive from Springfield to Southern Illinois University Edwardsville

$95 - $358

Bus to Milwaukee, fly to St. Louis  •  5 h 21 min

  1. Take the bus from Chicago, IL - O'Hare International Airport to Milwaukee, WI - Airport
  2. Fly from Milwaukee (MKE) to St. Louis (STL) MKE - STL

$227 - $405

Train  •  6 h

  1. Take the train from Chicago Union Station to St. Louis Gateway Station Lincoln Service / ...

$116 - $208

Bus Greyhound USA  •  6 h 13 min

  1. Take the bus from Chicago, Il to St Louis, Mo 1353 / ...

$95 - $163

Drive  •  4 h 37 min

  1. Drive from Chicago to Southern Illinois University Edwardsville 281.2 miles

$27 - $40

Questions & Answers

The cheapest way to get from Chicago to Southern Illinois University Edwardsville is to drive which costs $27 - $40 and takes 4 h 37 min.

More details

The quickest way to get from Chicago to Southern Illinois University Edwardsville is to fly which costs $190 - $400 and takes 3 h 9 min.

More details

The distance between Chicago and Southern Illinois University Edwardsville is 248 miles. The road distance is 281.2 miles.

Get driving directions

The best way to get from Chicago to Southern Illinois University Edwardsville without a car is to train which takes 6 h and costs $110 - $210.

More details

It takes approximately 3 h 9 min to get from Chicago to Southern Illinois University Edwardsville, including transfers.

More details

The best way to get from Chicago to Southern Illinois University Edwardsville is to fly which takes 3 h 9 min and costs $190 - $400. Alternatively, you can train, which costs $110 - $210 and takes 6 h, you could also bus, which costs $95 - $170 and takes 6 h 13 min.

Mode details

The quickest flight from Chicago Midway Airport to St. Louis Airport is the direct flight which takes 1 h 5 min.

Search flights

Yes, the driving distance between Chicago to Southern Illinois University Edwardsville is 281 miles. It takes approximately 4 h 37 min to drive from Chicago to Southern Illinois University Edwardsville.

Get driving directions

Southwest Airlines offers flights from Chicago Midway Airport to St. Louis Airport.

Search flights

There are 57+ hotels available in Southern Illinois University Edwardsville. Prices start at $55 USD per night.

More details

Map of how to get from Chicago to Southern Illinois University Edwardsville.
Launch map view
  • Distance: 248.3 miles
  • Duration: 3 h 9 min

What companies run services between Chicago, IL, USA and Southern Illinois University Edwardsville, IL, USA?

Southwest Airlines flies from Chicago to Southern Illinois University Edwardsville every 4 hours. Alternatively, Amtrak operates a train from Chicago to Southern Illinois University Edwardsville every 4 hours. Tickets cost $50 - $130 and the journey takes 5 h 30 min.

Airlines
Southwest Airlines
Website
southwest.com
Flights from Chicago Midway to St. Louis
Ave. Duration
1 h 7 min
When
Every day
Estimated price
$160 - $550
Flights from Milwaukee to St. Louis
Ave. Duration
1 h 16 min
When
Every day
Estimated price
$310 - $600
United Airlines
Website
united.com
Flights from Chicago O'Hare to St. Louis
Ave. Duration
1 h 20 min
When
Every day
Estimated price
$120 - $650
Flights from Chicago O'Hare to Springfield
Ave. Duration
1 h 3 min
When
Every day
Estimated price
$85 - $700
Flights from Milwaukee to St. Louis via Chicago O'Hare
Ave. Duration
3 h 12 min
When
Every day
Estimated price
$240 - $750
American Airlines
Website
aa.com
Flights from Chicago O'Hare to St. Louis
Ave. Duration
1 h 10 min
When
Every day
Estimated price
$120 - $550
Flights from Milwaukee to St. Louis via Chicago O'Hare
Ave. Duration
3 h 9 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$230 - $550
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Chicago Union Station to St. Louis Gateway Station
Ave. Duration
5 h 30 min
Frequency
Every 4 hours
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$90 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Bus operators
Coach USA
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Chicago, Il to St Louis, Mo
Ave. Duration
5 h 45 min
Frequency
Every 4 hours
Estimated price
$35 - $85
Website
greyhound.com
Economy
$35 - $55
Flexible
$65 - $85

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

The best way to get from Chicago to Chicago Midway Airport is to subway which takes 23 min and costs $2 - $4.

More details

Trips to Southern Illinois University Edwardsville