There are 12 ways to get from Chicago to South Carolina by plane, train, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Chicago O'Hare to Greenville/Spartanburg  •  3 h 46 min

  1. Fly from Chicago O'Hare (ORD) to Greenville/Spartanburg (GSP) ORD - GSP

$172 - $600

Cheapest option

Bus Megabus  •  21 h 40 min

  1. Take the bus from Chicago to Marta Civic Center Station - Nb
  2. Take the bus from Atlanta GA to Columbia, SC
  3. Take the bus from Columbia, SC to Florence, SC

$102 - $146

10 alternative options

Fly Chicago O'Hare to Columbia  •  3 h 52 min

  1. Fly from Chicago O'Hare (ORD) to Columbia (CAE) ORD - CAE

$236 - $585

Fly Chicago Midway to Charlotte  •  3 h 48 min

  1. Fly from Chicago Midway (MDW) to Charlotte (CLT) MDW - CLT

$237 - $534

Fly Chicago O'Hare to Charlotte  •  4 h 9 min

  1. Fly from Chicago O'Hare (ORD) to Charlotte (CLT) ORD - CLT

$207 - $445

Fly Chicago Midway to Charleston  •  4 h 33 min

  1. Fly from Chicago Midway (MDW) to Charleston (CHS) MDW - CHS

$174 - $607

Fly Chicago O'Hare to Charleston  •  4 h 57 min

  1. Fly from Chicago O'Hare (ORD) to Charleston (CHS) ORD - CHS

$144 - $478

Train to South Bend, fly to Charlotte  •  6 h 5 min

  1. Take the train from Van Buren St. to South Bend Airport
  2. Fly from South Bend (SBN) to Charlotte (CLT) SBN - CLT

$308 - $1,204

Bus Greyhound USA  •  23 h 8 min

  1. Take the bus from Chicago Amtrak, Il to Atlanta, Ga 1151 / ...
  2. Take the bus from Atlanta, GA to Florence, SC Atlanta

$108 - $236

Train  •  26 h 5 min

  1. Take the train from Chicago Union Station to Washington Union Station Capitol Limited
  2. Take the train from Washington Union Station to Florence Amtrak Palmetto / ...

$174 - $485

Train via Alexandria Amtrak  •  31 h 35 min

  1. Take the train from Chicago Union Station to Alexandria Amtrak Cardinal
  2. Take the train from Alexandria Amtrak to Florence Amtrak Palmetto / ...

$183 - $520

Drive  •  14 h 45 min

  1. Drive from Chicago to Florence 883.5 miles

$85 - $130

Questions & Answers

The cheapest way to get from Chicago to South Carolina is to drive which costs $85 - $130 and takes 14 h 45 min.

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The quickest way to get from Chicago to South Carolina is to fly which costs $170 - $600 and takes 3 h 46 min.

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No, there is no direct bus from Chicago to South Carolina. However, there are services departing from Chicago and arriving at Florence, SC via Atlanta GA and Columbia, SC. The journey, including transfers, takes approximately 21 h 40 min.

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No, there is no direct train from Chicago station to South Carolina. However, there are services departing from Chicago Union Station and arriving at Florence Amtrak via Washington Union Station. The journey, including transfers, takes approximately 26 h 5 min.

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The distance between Chicago and South Carolina is 692 miles. The road distance is 883.5 miles.

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The best way to get from Chicago to South Carolina without a car is to bus which takes 21 h 40 min and costs $100 - $150.

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It takes approximately 3 h 46 min to get from Chicago to South Carolina, including transfers.

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Chicago to South Carolina bus services, operated by Megabus, depart from Chicago station.

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Chicago to South Carolina train services, operated by Amtrak, arrive at Chicago Union Station.

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The best way to get from Chicago to South Carolina is to fly which takes 3 h 46 min and costs $170 - $600. Alternatively, you can bus, which costs $100 - $150 and takes 21 h 40 min, you could also train, which costs $170 - $490 and takes 26 h 5 min.

Mode details

Map of how to get from Chicago to South Carolina.
Launch map view
  • Distance: 692.1 miles
  • Duration: 3 h 46 min

What companies run services between Chicago, IL, USA and South Carolina, USA?

American Airlines, United Airlines and Delta fly from Chicago to Greenville hourly. Alternatively, you can take a bus from Chicago to Florence via Marta Civic Center Station - Nb, Atlanta GA, and Columbia, SC in around 21 h 40 min.

Airlines
American Airlines
Website
aa.com
Flights from Chicago O'Hare to Greenville/Spartanburg
Ave. Duration
1 h 48 min
When
Every day
Estimated price
$280 - $800
Flights from Chicago O'Hare to Greenville/Spartanburg via Charlotte
Ave. Duration
3 h 42 min
When
Every day
Estimated price
$280 - $800
Flights from Chicago O'Hare to Columbia via Charlotte
Ave. Duration
3 h 56 min
When
Every day
Estimated price
$400 - $1,100
Flights from Chicago O'Hare to Charlotte
Ave. Duration
1 h 58 min
When
Every day
Estimated price
$200 - $600
Flights from Chicago O'Hare to Charleston
Ave. Duration
2 h 27 min
When
Every day
Estimated price
$290 - $1,200
Flights from Chicago O'Hare to Charleston via Charlotte
Ave. Duration
4 h 4 min
When
Every day
Estimated price
$290 - $1,200
Flights from Chicago O'Hare to Charleston via Reagan Washington
Ave. Duration
4 h 21 min
When
Sunday
Estimated price
$290 - $1,200
Flights from South Bend to Charlotte
Ave. Duration
2 h 7 min
When
Every day
Estimated price
$220 - $1,100
United Airlines
Website
united.com
Flights from Chicago O'Hare to Greenville/Spartanburg
Ave. Duration
1 h 55 min
When
Every day
Estimated price
$280 - $1,100
Flights from Chicago O'Hare to Columbia
Ave. Duration
2 h 1 min
When
Every day
Estimated price
$320 - $900
Flights from Chicago O'Hare to Columbia via Washington Dulles
Ave. Duration
4 h 21 min
When
Every day
Estimated price
$320 - $900
Flights from Chicago O'Hare to Charlotte
Ave. Duration
2 h 5 min
When
Every day
Estimated price
$180 - $550
Flights from Chicago O'Hare to Charleston
Ave. Duration
2 h 21 min
When
Every day
Estimated price
$300 - $1,100
Flights from South Bend to Charlotte via Chicago O'Hare
Ave. Duration
4 h 21 min
When
Saturday
Estimated price
$250 - $1,200
Delta
Website
delta.com
Flights from Chicago O'Hare to Greenville/Spartanburg via Atlanta
Ave. Duration
3 h 54 min
When
Every day
Estimated price
$260 - $1,300
Flights from Chicago O'Hare to Columbia via Atlanta
Ave. Duration
4 h 24 min
When
Every day
Estimated price
$420 - $1,000
Flights from Chicago Midway to Charlotte via Detroit
Ave. Duration
4 h 11 min
When
Every day
Estimated price
$210 - $700
Flights from Chicago Midway to Charlotte via Atlanta
Ave. Duration
4 h 14 min
When
Every day
Estimated price
$210 - $700
Flights from Chicago Midway to Charleston via Atlanta
Ave. Duration
4 h 21 min
When
Every day
Estimated price
$280 - $1,400
Flights from Chicago Midway to Charleston via Detroit
Ave. Duration
4 h 36 min
When
Every day
Estimated price
$280 - $1,400
Flights from Chicago O'Hare to Charleston via Atlanta
Ave. Duration
4 h 9 min
When
Every day
Estimated price
$320 - $1,400
Flights from South Bend to Charlotte via Detroit
Ave. Duration
4 h 10 min
When
Every day
Estimated price
$220 - $1,100
Flights from South Bend to Charlotte via Atlanta
Ave. Duration
4 h 26 min
When
Every day
Estimated price
$230 - $1,200
Southwest Airlines
Website
southwest.com
Flights from Chicago Midway to Charlotte
Ave. Duration
1 h 49 min
When
Every day
Estimated price
$310 - $800
Flights from Chicago Midway to Charlotte via Nashville
Ave. Duration
3 h 35 min
When
Monday to Friday
Estimated price
$310 - $800
Flights from Chicago Midway to Charlotte via Baltimore
Ave. Duration
4 h 20 min
When
Sunday
Estimated price
$310 - $800
Flights from Chicago Midway to Charleston
Ave. Duration
2 h
When
Every day
Estimated price
$350 - $1,600
Flights from Chicago Midway to Charleston via Nashville
Ave. Duration
3 h 45 min
When
Saturday
Estimated price
$350 - $1,600
Flights from Chicago Midway to Charleston via Baltimore
Ave. Duration
4 h 30 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$350 - $1,600
Frontier Airlines
Website
flyfrontier.com
Flights from Chicago O'Hare to Charleston
Ave. Duration
2 h 17 min
When
Monday and Friday
Estimated price
$110 - $550
Train operators
South Shore Line
Phone
+1 219-926-5744
Website
nictd.com
Train from Van Buren St. to South Bend Airport
Ave. Duration
2 h 25 min
Frequency
Hourly
Estimated price
$12 - $14
Schedules at
nictd.com
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Chicago Union Station to Washington Union Station
Ave. Duration
17 h 25 min
Frequency
Once daily
Estimated price
$100 - $310
Website
amtrak.com
Coach Seat
$100 - $160
Flexi Coach Seat
$190 - $280
Business Coach Seat
$220 - $310
Room
$440 - $600
Train from Washington Union Station to Florence Amtrak
Ave. Duration
7 h 40 min
Frequency
Twice daily
Estimated price
$65 - $180
Website
amtrak.com
Coach Seat
$65 - $100
Flexi Coach Seat
$110 - $170
Business Coach Seat
$120 - $180
Room
$280 - $400
Train from Chicago Union Station to Alexandria Amtrak
Ave. Duration
23 h 14 min
Frequency
4 times a week
Estimated price
$120 - $350
Website
amtrak.com
Coach Seat
$120 - $180
Flexi Coach Seat
$210 - $310
Business Coach Seat
$250 - $350
Room
$490 - $700
Train from Alexandria Amtrak to Florence Amtrak
Ave. Duration
7 h 21 min
Frequency
Twice daily
Estimated price
$60 - $170
Website
amtrak.com
Coach Seat
$60 - $95
Flexi Coach Seat
$110 - $170
Business Coach Seat
$120 - $170
Room
$280 - $390
Bus operators
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Chicago to Marta Civic Center Station - Nb
Ave. Duration
14 h 5 min
Frequency
Twice daily
Estimated price
$60 - $85
Book at
megabus.com
Bus from Atlanta GA to Columbia, SC
Ave. Duration
4 h 15 min
Frequency
Twice daily
Estimated price
$21 - $35
Book at
megabus.com
South Eastern Stages
Phone
+1 877.836.7607 / 404.591.2750
Email
info@sestages.com
Website
southeasternstages.com
Bus from Columbia, SC to Florence, SC
Ave. Duration
1 h 20 min
Frequency
Once daily
Estimated price
$19 - $30
Schedules at
southeasternstages.com
Bus from Atlanta, GA to Florence, SC
Ave. Duration
5 h 30 min
Frequency
Once daily
Estimated price
$35 - $60
Schedules at
southeasternstages.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Chicago Amtrak, Il to Atlanta, Ga
Ave. Duration
16 h 30 min
Frequency
Hourly
Estimated price
$70 - $180
Website
greyhound.com
Economy
$70 - $120
Flexible
$130 - $180

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More Questions & Answers

The quickest flight from Chicago O'Hare Airport to Greenville/Spartanburg Airport is the direct flight which takes 1 h 46 min.

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Chicago to South Carolina bus services, operated by South Eastern Stages, arrive at Florence, SC station.

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South Carolina is 1 h ahead of Chicago. It is currently 11:16 AM in Chicago and 12:16 PM in South Carolina.

Chicago to South Carolina train services, operated by Amtrak, arrive at Florence Amtrak station.

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Yes, the driving distance between Chicago to South Carolina is 884 miles. It takes approximately 14 h 45 min to drive from Chicago to South Carolina.

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United Airlines, Delta and American Airlines offer flights from Chicago O'Hare Airport to Greenville/Spartanburg Airport.

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Book your Chicago to South Carolina train tickets online with Rome2rio.

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There are 16+ hotels available in South Carolina. Prices start at $52 USD per night.

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The best way to get from Chicago to Chicago O'Hare Airport is to subway which takes 43 min and costs $2 - $5.

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