Travel options for:
Chicago to South Carolina
  • Fly Chicago O'Hare to Greenville/Spartanburg

    $172 - $600
    1. Chicago

      43 min - every 10 minutes

      $2 - $5

    2. Chicago O'Hare (ORD)

      1 h 47 min - non-stop

      $140 - $550

    3. Greenville/Spartanburg (GSP)

      17 min - 13 miles

      $30 - $45

  • Fly Chicago O'Hare to Columbia

    $236 - $585
    1. Chicago

      43 min - every 10 minutes

      $2 - $5

    2. Chicago O'Hare (ORD)

      1 h 58 min - non-stop

      $210 - $550

    3. Columbia (CAE)

      11 min - 7.4 miles

      $24 - $30

  • Fly Chicago Midway to Charlotte

    $237 - $534
    1. Chicago

      23 min - every 15 minutes

      $2 - $4

    2. Chicago Midway (MDW)

      1 h 45 min - non-stop

      $160 - $440

    3. Charlotte (CLT)

      33 min - 26.5 miles

      $75 - $90

  • Fly Chicago O'Hare to Charlotte

    $207 - $445
    1. Chicago

      43 min - every 10 minutes

      $2 - $5

    2. Chicago O'Hare (ORD)

      1 h 52 min - non-stop

      $130 - $350

    3. Charlotte (CLT)

      33 min - 26.5 miles

      $75 - $90

  • Fly Chicago Midway to Charleston

    $175 - $610
    1. Chicago

      23 min - every 15 minutes

      $2 - $4

    2. Chicago Midway (MDW)

      2 h - non-stop

      $170 - $600

    3. Charleston (CHS)

      25 min - hourly - line 11

      $2 - $3

    4. N. Charleston SuperStop on

      10 min - every 30 minutes - line 10

      $1 - $3

  • Bus Megabus

    $80 - $116
    1. Chicago

      14 h 30 min - twice daily

      $55 - $85

    2. Atlanta, GA - Marta Civic

      3 h 40 min - 5 times a day

      $21 - $35

  • Bus Greyhound USA

    $100 - $217
    1. Chicago, IL

      15 h - once daily

      $70 - $170

    2. Atlanta, GA

      6 h 10 min - 3 times a day

      $30 - $50

  • Train

    $184 - $515
    1. Chicago Union Station Amtrak

      17 h 25 min - once daily

      $100 - $310

    2. Washington Union Station

      10 h 33 min - once daily

      $75 - $210

  • Train via Alexandria Amtrak

    $198 - $560
    1. Chicago Union Station Amtrak

      23 h 14 min - 3 times a week

      $120 - $350

    2. Alexandria Amtrak

      10 h 15 min - once daily

      $75 - $210

  • Drive

    $75 - $120
    1. Chicago

      13 h 15 min - 805.2 miles

      $75 - $120

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From Jackson-Blue subway to Chicago O'Hare airport, fly to Greenville/Spartanburg airport, then taxi to Greenville. 3 h 47 min $284. From Jackson-Blue subway to Chicago O'Hare airport, fly to Columbia airport, then taxi to Columbia. 3 h 52 min $423. From Adams/Wabash subway to Chicago Midway airport, fly to Charlotte airport, then taxi to Rock Hill. 3 h 41 min $433. From Jackson-Blue subway to Chicago O'Hare airport, fly to Charlotte airport, then taxi to Rock Hill. 4 h 8 min $304. From Adams/Wabash subway to Chicago Midway airport, fly to Charleston airport, line 11 bus to N. Charleston SuperStop on Rivers Ave, then line 10 bus to North Charleston. 4 h 28 min $357. From Chicago bus to Atlanta, GA - Marta Civic Center Station then bus to Columbia. 19 h 10 min $94. From Chicago, IL bus to Atlanta, GA then bus to Columbia. 22 h 10 min $123. From Chicago Union Station Amtrak train to Washington Union Station Amtrak then train to Columbia Amtrak. 28 h 58 min $370. From Chicago Union Station Amtrak train to Alexandria Amtrak then train to Columbia Amtrak. 34 h 29 min $403. From Chicago drive to Columbia. 13 h 15 min $96.