There are 11 ways to get from Chicago to South Carolina by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Chicago O'Hare to Greenville/Spartanburg  •  3 h 46 min

  1. Fly from Chicago O'Hare (ORD) to Greenville/Spartanburg (GSP) ORD - GSP

$172 - $600

Cheapest option

Bus Megabus  •  24 h 9 min

  1. Take the bus from Chicago to Marta Civic Center Station - Nb
  2. Take the bus from Atlanta, GA to Florence 0983 / ...

$102 - $149

9 alternative options

Fly Chicago O'Hare to Columbia  •  3 h 59 min

  1. Fly from Chicago O'Hare (ORD) to Columbia (CAE) ORD - CAE

$236 - $585

Fly Chicago Midway to Charlotte  •  3 h 43 min

  1. Fly from Chicago Midway (MDW) to Charlotte (CLT) MDW - CLT

$237 - $534

Fly Chicago O'Hare to Charlotte  •  4 h 7 min

  1. Fly from Chicago O'Hare (ORD) to Charlotte (CLT) ORD - CLT

$207 - $445

Fly Chicago Midway to Charleston  •  4 h 33 min

  1. Fly from Chicago Midway (MDW) to Charleston (CHS) MDW - CHS

$174 - $607

Fly Chicago O'Hare to Charleston  •  4 h 57 min

  1. Fly from Chicago O'Hare (ORD) to Charleston (CHS) ORD - CHS

$144 - $478

Bus Greyhound USA  •  24 h 42 min

  1. Take the bus from Chicago, Il to Atlanta, Ga
  2. Take the bus from Atlanta, Ga to Savannah, Ga
  3. Take the bus from Savannah, Ga to Florence, Sc

$121 - $298

Train  •  26 h 5 min

  1. Take the train from Chicago Union Station Amtrak to Washington Union Station Amtrak Capitol Limited
  2. Take the train from Washington Union Station Amtrak to Florence Amtrak Palmetto / ...

$174 - $485

Train via Alexandria Amtrak  •  31 h 35 min

  1. Take the train from Chicago Union Station Amtrak to Alexandria Amtrak Cardinal
  2. Take the train from Alexandria Amtrak to Florence Amtrak Palmetto / ...

$183 - $520

Drive  •  14 h 45 min

  1. Drive from Chicago to Florence 883.5 miles

$85 - $130

Questions & Answers

The cheapest way to get from Chicago to South Carolina is to drive which costs $85 - $130 and takes 14 h 45 min.

More details

The quickest way to get from Chicago to South Carolina is to fly which takes 3 h 43 min and costs $230 - $550.

More details

The distance between Chicago and South Carolina is 1107 km. The road distance is 1414 km.

Get driving directions

It takes approximately 3 h 46 min to get from Chicago to South Carolina, including transfers.

More details

No, there is no direct bus from Chicago to South Carolina. However, there are services departing from Chicago, Il and arriving at Florence, Sc via Atlanta, Ga and Savannah, Ga. The journey, including transfers, takes approximately 24 h 42 min.

More details

No, there is no direct train from Chicago to South Carolina. However, there are services departing from Chicago Union Station Amtrak and arriving at Florence Amtrak via Washington Union Station Amtrak. The journey, including transfers, takes approximately 26 h 5 min.

More details

What companies run services between Chicago, IL, USA and South Carolina, USA?

American Airlines, United Airlines and Delta fly from Chicago to Greenville hourly. Alternatively, you can take a bus from Chicago to Florence via Marta Civic Center Station - Nb, Civic Center Station, Garnett Station, and Atlanta, GA in around 24 h 9 min.

Airlines
American Airlines
Website
aa.com
Flights from Chicago O'Hare to Greenville/Spartanburg
Ave. Duration
1 h 47 min
When
Every day
Estimated price
$280 - $800
Flights from Chicago O'Hare to Greenville/Spartanburg via Charlotte
Ave. Duration
3 h 47 min
When
Every day
Estimated price
$280 - $800
Flights from Chicago O'Hare to Columbia via Charlotte
Ave. Duration
4 h
When
Every day
Estimated price
$400 - $1,100
Flights from Chicago O'Hare to Columbia via Reagan Washington
Ave. Duration
4 h 33 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$400 - $1,100
Flights from Chicago O'Hare to Charlotte
Ave. Duration
1 h 58 min
When
Every day
Estimated price
$200 - $600
Flights from Chicago O'Hare to Charlotte via Dayton
Ave. Duration
3 h 43 min
When
Saturday
Estimated price
$200 - $600
Flights from Chicago O'Hare to Charleston
Ave. Duration
2 h 14 min
When
Every day
Estimated price
$290 - $1,200
Flights from Chicago O'Hare to Charleston via Charlotte
Ave. Duration
3 h 50 min
When
Every day
Estimated price
$290 - $1,200
Southwest Airlines
Website
southwest.com
Flights from Chicago Midway to Charlotte
Ave. Duration
1 h 47 min
When
Every day
Estimated price
$310 - $800
Flights from Chicago Midway to Charlotte via Nashville
Ave. Duration
3 h 30 min
When
Sunday
Estimated price
$310 - $800
Flights from Chicago Midway to Charleston
Ave. Duration
2 h 2 min
When
Every day
Estimated price
$350 - $1,600
Flights from Chicago Midway to Charleston via Nashville
Ave. Duration
4 h 13 min
When
Saturday and Sunday
Estimated price
$350 - $1,600
Flights from Chicago Midway to Charleston via Baltimore
Ave. Duration
4 h 17 min
When
Monday to Saturday
Estimated price
$350 - $1,600
United Airlines
Website
united.com
Flights from Chicago O'Hare to Greenville/Spartanburg
Ave. Duration
1 h 55 min
When
Every day
Estimated price
$280 - $1,100
Flights from Chicago O'Hare to Columbia
Ave. Duration
2 h 5 min
When
Every day
Estimated price
$320 - $900
Flights from Chicago O'Hare to Columbia via Washington Dulles
Ave. Duration
4 h 15 min
When
Every day
Estimated price
$320 - $900
Flights from Chicago O'Hare to Charlotte
Ave. Duration
2 h 7 min
When
Every day
Estimated price
$180 - $550
Flights from Chicago O'Hare to Charleston
Ave. Duration
2 h 12 min
When
Every day
Estimated price
$300 - $1,100
Delta
Website
delta.com
Flights from Chicago O'Hare to Greenville/Spartanburg via Atlanta
Ave. Duration
3 h 52 min
When
Every day
Estimated price
$260 - $1,300
Flights from Chicago O'Hare to Greenville/Spartanburg via Detroit
Ave. Duration
4 h 6 min
When
Every day
Estimated price
$260 - $1,300
Flights from Chicago O'Hare to Columbia via Atlanta
Ave. Duration
4 h 21 min
When
Every day
Estimated price
$420 - $1,000
Flights from Chicago Midway to Charlotte via Atlanta
Ave. Duration
4 h 2 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$210 - $700
Flights from Chicago Midway to Charlotte via Detroit
Ave. Duration
4 h 8 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$210 - $700
Flights from Chicago Midway to Charleston via Atlanta
Ave. Duration
4 h 14 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$280 - $1,400
Flights from Chicago Midway to Charleston via Detroit
Ave. Duration
4 h 36 min
When
Every day
Estimated price
$280 - $1,400
Flights from Chicago O'Hare to Charleston via Atlanta
Ave. Duration
4 h 9 min
When
Every day
Estimated price
$320 - $1,400
Frontier Airlines
Website
flyfrontier.com
Flights from Chicago O'Hare to Charleston
Ave. Duration
2 h 14 min
When
Monday and Friday
Estimated price
$110 - $550
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Chicago Union Station Amtrak to Washington Union Station Amtrak
Ave. Duration
17 h 25 min
Frequency
Once daily
Estimated price
$100 - $310
Website
amtrak.com
Coach Seat
$100 - $160
Flexi Coach Seat
$190 - $280
Business Coach Seat
$220 - $310
Room
$440 - $600
Train from Washington Union Station Amtrak to Florence Amtrak
Ave. Duration
7 h 40 min
Frequency
4 times a day
Estimated price
$65 - $180
Website
amtrak.com
Coach Seat
$65 - $100
Flexi Coach Seat
$110 - $170
Business Coach Seat
$120 - $180
Room
$280 - $400
Train from Chicago Union Station Amtrak to Alexandria Amtrak
Ave. Duration
23 h 14 min
Frequency
4 times a week
Estimated price
$120 - $350
Website
amtrak.com
Coach Seat
$120 - $180
Flexi Coach Seat
$210 - $310
Business Coach Seat
$250 - $350
Room
$490 - $700
Train from Alexandria Amtrak to Florence Amtrak
Ave. Duration
7 h 21 min
Frequency
4 times a day
Estimated price
$60 - $170
Website
amtrak.com
Coach Seat
$60 - $95
Flexi Coach Seat
$110 - $170
Business Coach Seat
$120 - $170
Room
$280 - $390
Bus operators
Megabus
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Chicago, Il to Atlanta, Ga
Ave. Duration
15 h 45 min
Frequency
Every 3 hours
Estimated price
$70 - $180
Website
greyhound.com
Economy
$70 - $120
Flexible
$130 - $180
Bus from Atlanta, Ga to Savannah, Ga
Ave. Duration
4 h 35 min
Frequency
Every 30 minutes
Estimated price
$29 - $70
Website
greyhound.com
Economy
$29 - $50
Flexible
$55 - $70
Bus from Savannah, Ga to Florence, Sc
Ave. Duration
3 h 40 min
Frequency
Hourly
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55

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