• Our partners include:

  • Greyhound USA
  • VIA Rail
  • Amtrak
  • Acela Express
  • Megabus
  • SuperShuttle
  • Booking.com
  • Skyscanner
  • Airbnb
  • Expedia

There are 11 ways to get from Chicago to South Carolina by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Chicago O'Hare to Greenville/Spartanburg  •  3 h 41 min

  1. Fly from Chicago O'Hare (ORD) to Greenville/Spartanburg (GSP) ORD - GSP

$172 - $600

Cheapest option

Bus Megabus  •  21 h 40 min

  1. Take the bus from Chicago to Marta Civic Center Station - Nb
  2. Take the bus from Atlanta GA to Columbia, SC
  3. Take the bus from Columbia, SC to Florence, SC

$102 - $146

9 alternative options

Fly Chicago O'Hare to Columbia  •  3 h 51 min

  1. Fly from Chicago O'Hare (ORD) to Columbia (CAE) ORD - CAE

$236 - $585

Fly Chicago Midway to Charleston  •  4 h 33 min

  1. Fly from Chicago Midway (MDW) to Charleston (CHS) MDW - CHS

$174 - $607

Fly Chicago O'Hare to Charleston  •  4 h 55 min

  1. Fly from Chicago O'Hare (ORD) to Charleston (CHS) ORD - CHS

$144 - $478

Fly Chicago Midway to Charlotte, bus  •  6 h 2 min

  1. Fly from Chicago Midway (MDW) to Charlotte (CLT) MDW - CLT
  2. Take the bus from Transit Center- Bay X to White Street Park and Ride

$168 - $452

Fly Chicago O'Hare to Charlotte, bus  •  6 h 28 min

  1. Fly from Chicago O'Hare (ORD) to Charlotte (CLT) ORD - CLT
  2. Take the bus from Transit Center- Bay X to White Street Park and Ride

$138 - $363

Bus Greyhound USA  •  22 h 23 min

  1. Take the bus from Chicago, Il to Atlanta, Ga 1151 / ...
  2. Take the bus from Atlanta, GA to Florence, SC Atlanta

$108 - $236

Train  •  26 h 5 min

  1. Take the train from Chicago Union Station to Washington Union Station Capitol Limited
  2. Take the train from Washington Union Station to Florence Amtrak Station Palmetto / ...

$174 - $485

Train via Alexandria Amtrak Station  •  31 h 35 min

  1. Take the train from Chicago Union Station to Alexandria Amtrak Station Cardinal
  2. Take the train from Alexandria Amtrak Station to Florence Amtrak Station Palmetto / ...

$183 - $520

Drive  •  14 h 45 min

  1. Drive from Chicago to Florence 883.5 miles

$85 - $130

Questions & Answers

The cheapest way to get from Chicago to South Carolina is to drive which costs $85 - $130 and takes 14 h 45 min.

More details

The quickest way to get from Chicago to South Carolina is to fly which costs $170 - $600 and takes 3 h 41 min.

More details

No, there is no direct bus from Chicago to South Carolina. However, there are services departing from Chicago and arriving at Florence, SC via Atlanta GA and Columbia, SC. The journey, including transfers, takes approximately 21 h 40 min.

More details

No, there is no direct train from Chicago station to South Carolina station. However, there are services departing from Chicago Union Station and arriving at Florence Amtrak Station via Washington Union Station. The journey, including transfers, takes approximately 26 h 5 min.

More details

The distance between Chicago and South Carolina is 692 miles. The road distance is 883.5 miles.

Get driving directions

The best way to get from Chicago to South Carolina without a car is to bus which takes 21 h 40 min and costs $100 - $150.

More details

It takes approximately 3 h 41 min to get from Chicago to South Carolina, including transfers.

More details

Chicago to South Carolina bus services, operated by Megabus, depart from Chicago station.

More details

Chicago to South Carolina train services, operated by Amtrak, arrive at Chicago Union Station.

More details

The best way to get from Chicago to South Carolina is to fly which takes 3 h 41 min and costs $170 - $600. Alternatively, you can bus, which costs $100 - $150 and takes 21 h 40 min, you could also train, which costs $170 - $490 and takes 26 h 5 min.

Mode details

Map of how to get from Chicago to South Carolina.
Launch map view
  • Distance: 692.1 miles
  • Duration: 3 h 41 min

What companies run services between Chicago, IL, USA and South Carolina, USA?

American Airlines, United Airlines and Delta fly from Chicago to Greenville hourly. Alternatively, you can take a bus from Chicago to Florence via Atlanta GA and Columbia, SC in around 21 h 40 min.

Airlines
American Airlines
Website
aa.com
Flights from Chicago O'Hare to Greenville/Spartanburg
Ave. Duration
1 h 45 min
When
Every day
Estimated price
$280 - $800
Flights from Chicago O'Hare to Greenville/Spartanburg via Charlotte
Ave. Duration
3 h 50 min
When
Every day
Estimated price
$280 - $800
Flights from Chicago O'Hare to Columbia via Charlotte
Ave. Duration
4 h
When
Every day
Estimated price
$400 - $1,100
Flights from Chicago O'Hare to Charleston
Ave. Duration
2 h 29 min
When
Monday, Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
$290 - $1,200
Flights from Chicago O'Hare to Charleston via Charlotte
Ave. Duration
4 h 3 min
When
Every day
Estimated price
$290 - $1,200
Flights from Chicago O'Hare to Charlotte
Ave. Duration
1 h 58 min
When
Every day
Estimated price
$200 - $600
United Airlines
Website
united.com
Flights from Chicago O'Hare to Greenville/Spartanburg
Ave. Duration
1 h 55 min
When
Every day
Estimated price
$280 - $1,100
Flights from Chicago O'Hare to Columbia
Ave. Duration
2 h
When
Every day
Estimated price
$320 - $900
Flights from Chicago O'Hare to Columbia via Washington Dulles
Ave. Duration
4 h 9 min
When
Every day
Estimated price
$320 - $900
Flights from Chicago O'Hare to Charleston
Ave. Duration
2 h 17 min
When
Every day
Estimated price
$300 - $1,100
Flights from Chicago O'Hare to Charlotte
Ave. Duration
2 h 2 min
When
Every day
Estimated price
$180 - $550
Southwest Airlines
Website
southwest.com
Flights from Chicago Midway to Charleston
Ave. Duration
2 h
When
Every day
Estimated price
$350 - $1,600
Flights from Chicago Midway to Charleston via Nashville
Ave. Duration
3 h 51 min
When
Wednesday, Saturday and Sunday
Estimated price
$350 - $1,600
Flights from Chicago Midway to Charleston via Baltimore
Ave. Duration
4 h 15 min
When
Wednesday, Thursday and Friday
Estimated price
$350 - $1,600
Flights from Chicago Midway to Charlotte
Ave. Duration
1 h 43 min
When
Every day
Estimated price
$310 - $800
Flights from Chicago Midway to Charlotte via Nashville
Ave. Duration
3 h 38 min
When
Saturday and Sunday
Estimated price
$310 - $800
Delta
Website
delta.com
Flights from Chicago O'Hare to Columbia via Atlanta
Ave. Duration
4 h 7 min
When
Every day
Estimated price
$420 - $1,000
Flights from Chicago Midway to Charleston via Atlanta
Ave. Duration
4 h 3 min
When
Every day
Estimated price
$280 - $1,400
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Chicago Union Station to Washington Union Station
Ave. Duration
17 h 25 min
Frequency
Once daily
Estimated price
$100 - $310
Website
amtrak.com
Coach Seat
$100 - $160
Flexi Coach Seat
$190 - $280
Business Coach Seat
$220 - $310
Room
$440 - $600
Train from Washington Union Station to Florence Amtrak Station
Ave. Duration
7 h 40 min
Frequency
Twice daily
Estimated price
$65 - $180
Website
amtrak.com
Coach Seat
$65 - $100
Flexi Coach Seat
$110 - $170
Business Coach Seat
$120 - $180
Room
$280 - $400
Train from Chicago Union Station to Alexandria Amtrak Station
Ave. Duration
23 h 14 min
Frequency
4 times a week
Estimated price
$120 - $350
Website
amtrak.com
Coach Seat
$120 - $180
Flexi Coach Seat
$210 - $310
Business Coach Seat
$250 - $350
Room
$490 - $700
Train from Alexandria Amtrak Station to Florence Amtrak Station
Ave. Duration
7 h 21 min
Frequency
Twice daily
Estimated price
$60 - $170
Website
amtrak.com
Coach Seat
$60 - $95
Flexi Coach Seat
$110 - $170
Business Coach Seat
$120 - $170
Room
$280 - $390
Bus operators
Charlotte Area Transit System
Phone
+1 704-336-7433
Email
telltransit@charlottenc.gov
Website
charlottenc.gov
Bus from Transit Center- Bay X to White Street Park and Ride
Ave. Duration
1 h 12 min
Frequency
3 times a day
Estimated price
$3 - $5
Schedules at
charlottenc.gov
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Chicago to Marta Civic Center Station - Nb
Ave. Duration
14 h 5 min
Frequency
Twice daily
Estimated price
$60 - $85
Book at
megabus.com
Bus from Atlanta GA to Columbia, SC
Ave. Duration
4 h 15 min
Frequency
Twice daily
Estimated price
$21 - $35
Book at
megabus.com
South Eastern Stages
Phone
+1 877.836.7607 / 404.591.2750
Email
info@sestages.com
Website
southeasternstages.com
Bus from Columbia, SC to Florence, SC
Ave. Duration
1 h 20 min
Frequency
Once daily
Estimated price
$19 - $30
Schedules at
southeasternstages.com
Bus from Atlanta, GA to Florence, SC
Ave. Duration
5 h 30 min
Frequency
Once daily
Estimated price
$35 - $60
Schedules at
southeasternstages.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Chicago, Il to Atlanta, Ga
Ave. Duration
15 h 45 min
Frequency
4 times a day
Estimated price
$70 - $180
Website
greyhound.com
Economy
$70 - $120
Flexible
$130 - $180

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

The quickest flight from Chicago O'Hare Airport to Greenville/Spartanburg Airport is the direct flight which takes 1 h 42 min.

Search flights

Chicago to South Carolina bus services, operated by South Eastern Stages, arrive at Florence, SC station.

More details

South Carolina is 1 h ahead of Chicago. It is currently 9:57 AM in Chicago and 10:57 AM in South Carolina.

Chicago to South Carolina train services, operated by Amtrak, arrive at Florence Amtrak Station.

More details

Yes, the driving distance between Chicago to South Carolina is 884 miles. It takes approximately 14 h 45 min to drive from Chicago to South Carolina.

Get driving directions

United Airlines and American Airlines offer flights from Chicago O'Hare Airport to Greenville/Spartanburg Airport.

Search flights

Book your Chicago to South Carolina train tickets online with Rome2rio.

Search and book

There are 19+ hotels available in South Carolina. Prices start at $49 USD per night.

More details

The best way to get from Chicago to Chicago O'Hare Airport is to subway which takes 42 min and costs $2 - $5.

More details