Travel from Chicago to South-Carolina

Train, bus or fly from Chicago to South Carolina?

American Airlines, United Airlines and Delta fly from Chicago to Greenville hourly. Alternatively, you can take a bus from Chicago to Florence via Civic Center Station and Atlanta, GA in around 24 h 9 min.

Travel Guides

Need to know: GreyhoundRome2rio’s guide on the bus operator has all the information you need
Want to know more about US trains?Rome2rio has everything you need to know about travelling with Amtrak

How to get from Chicago to South Carolina

ModeDurationPrice
From Jackson-Blue subway to Chicago O'Hare airport, fly to Greenville/Spartanburg airport, then taxi to Greenville.3 h 45 min$284
From Jackson-Blue subway to Chicago O'Hare airport, fly to Columbia airport, then taxi to Columbia.3 h 54 min$423
From Adams/Wabash subway to Chicago Midway airport, fly to Charlotte airport, then taxi to Rock Hill.3 h 40 min$433
From Jackson-Blue subway to Chicago O'Hare airport, fly to Charlotte airport, then taxi to Rock Hill.4 h 9 min$304
From Adams/Wabash subway to Chicago Midway airport, fly to Charleston airport, then line 11 bus to North Charleston.4 h 25 min$355
From Jackson-Blue subway to Chicago O'Hare airport, fly to Charleston airport, then line 11 bus to North Charleston.4 h 59 min$266
From Chicago bus to Civic Center Station, subway to Atlanta, GA, then bus to Florence.24 h 9 min$124
From Chicago, IL bus to Atlanta, GA then bus to Florence.24 h 30 min$125
From Chicago Union Station Amtrak train to Washington Union Station Amtrak then train to Florence Amtrak.26 h 5 min$350
From Chicago Union Station Amtrak train to Alexandria Amtrak then train to Florence Amtrak.31 h 35 min$373
From Chicago drive to Florence.14 h 45 min$105

How long does it take to get from Chicago to South Carolina?

It takes approximately 3 h 45 min to get from Chicago to South Carolina, including transfers.

Is there a direct train between Chicago and South Carolina?

No, there is no direct train from Chicago to South Carolina. However, there are services departing from Chicago Union Station Amtrak and arriving at Florence Amtrak via Washington Union Station Amtrak. The journey, including transfers, takes approximately 26 h 5 min.

Is there a direct bus between Chicago and South Carolina?

No, there is no direct bus from Chicago to South Carolina. However, there are services departing from Chicago, IL and arriving at Florence via Atlanta, GA. The journey, including transfers, takes approximately 24 h 30 min.

Operators from Chicago to South Carolina

OperatorPhoneWebsite
Chicago Transit (CTA)Chicago Transit (CTA)
American AirlinesAmerican Airlines
United AirlinesUnited Airlines
DeltaDelta
Southwest AirlinesSouthwest Airlines
Charleston Area RTACharleston Area RTA
Frontier AirlinesFrontier Airlines
Megabus877-462-6342Megabus
MARTA Atlanta Rapid TransitMARTA Atlanta Rapid Transit
South Eastern Stages+1 877.836.7607 / 404.591.2750South Eastern Stages
Greyhound USA+1 214-849-8100Greyhound USA
Amtrak+1 1-800-872-7245Amtrak
Close Print Itinerary
  1. Here are 11 options to get from
    Chicago to South Carolina:

    1. Trip:
      1 Fly Chicago O'Hare to Greenville/Spartanburg
      • One-Way approx: USD $172 - $600
      • Duration: 3 h 45 min
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      • Trip:
        1 Fly Chicago O'Hare to Greenville/Spartanburg
        • One-Way approx: USD $172 - $600
        • Duration: 3 h 45 min
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    2. Trip:
      2 Fly Chicago O'Hare to Columbia
      • One-Way approx: USD $236 - $585
      • Duration: 3 h 54 min
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      • Trip:
        2 Fly Chicago O'Hare to Columbia
        • One-Way approx: USD $236 - $585
        • Duration: 3 h 54 min
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    3. Trip:
      3 Fly Chicago Midway to Charlotte
      • One-Way approx: USD $237 - $534
      • Duration: 3 h 40 min
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      • Trip:
        3 Fly Chicago Midway to Charlotte
        • One-Way approx: USD $237 - $534
        • Duration: 3 h 40 min
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    4. Trip:
      4 Fly Chicago O'Hare to Charlotte
      • One-Way approx: USD $207 - $445
      • Duration: 4 h 9 min
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      • Trip:
        4 Fly Chicago O'Hare to Charlotte
        • One-Way approx: USD $207 - $445
        • Duration: 4 h 9 min
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    5. Trip:
      5 Fly Chicago Midway to Charleston
      • One-Way approx: USD $174 - $607
      • Duration: 4 h 25 min
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      • Trip:
        5 Fly Chicago Midway to Charleston
        • One-Way approx: USD $174 - $607
        • Duration: 4 h 25 min
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    6. Trip:
      6 Fly Chicago O'Hare to Charleston
      • One-Way approx: USD $144 - $478
      • Duration: 4 h 59 min
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      • Trip:
        6 Fly Chicago O'Hare to Charleston
        • One-Way approx: USD $144 - $478
        • Duration: 4 h 59 min
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    7. Trip:
      7 Bus Megabus
      • One-Way approx: USD $102 - $149
      • Duration: 24 h 9 min
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      • Trip:
        7 Bus Megabus
        • One-Way approx: USD $102 - $149
        • Duration: 24 h 9 min
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    8. Trip:
      8 Bus Greyhound USA
      • One-Way approx: USD $110 - $239
      • Duration: 24 h 30 min
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      • Trip:
        8 Bus Greyhound USA
        • One-Way approx: USD $110 - $239
        • Duration: 24 h 30 min
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    9. Trip:
      9 Train
      • One-Way approx: USD $174 - $485
      • Duration: 26 h 5 min
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      • Trip:
        9 Train
        • One-Way approx: USD $174 - $485
        • Duration: 26 h 5 min
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    10. Trip:
      10 Train via Alexandria Amtrak
      • One-Way approx: USD $183 - $520
      • Duration: 31 h 35 min
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      • Trip:
        10 Train via Alexandria Amtrak
        • One-Way approx: USD $183 - $520
        • Duration: 31 h 35 min
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    11. Trip:
      11 Drive
      • One-Way approx: USD $85 - $130
      • Duration: 14 h 45 min
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      • Trip:
        11 Drive
        • One-Way approx: USD $85 - $130
        • Duration: 14 h 45 min
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