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How to get fromChicago to Simpsonvilleby plane, bus (Greyhound, Flixbus), train, bus, taxi, or car

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There are 7 ways to get from Chicago to Simpsonville by plane, bus (Greyhound, Flixbus), train, bus, taxi, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Greenville–Spartanburg International Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP)plane plane ORD - GSP
    4h 5m
    $132–600

  2. Fly Chicago O'Hare International Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Asheville Regional Airport (AVL)plane plane ORD - AVL
    2. Drive from Asheville-Airport-AVL to Simpsonvillecar car
    4h 55m
    $74–362

  3. Bus

    1. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus Greyhound US0100
    2. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus Charlotte
    21h 32m
    $197–408

  4. Train, bus, taxi

    1. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    2. Take the train from Raleigh Union Station to Charlotte Amtrak Stationtrain train
    3. Take the bus from Charlotte to Servicios Zapata - Spartanburgbus bus
    4. Take the taxi from Servicios Zapata - Spartanburg to Simpsonvilletaxi taxi
    32h 1m
    $517–1,051

  5. Drive 680.6 mi

    1. Drive from Chicago to Simpsonvillecar car 680.6 mi
    13h
    $125–180

  6. Fly Chicago O'Hare International Airport to Columbia, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Columbia (CAE)plane plane ORD - CAE
    2. Drive from Columbia-Airport-CAE to Simpsonvillecar car
    5h 26m
    $198–980

  7. Fly Chicago Midway International Airport to Asheville Regional Airport, drive

    1. Fly from Chicago Midway International Airport (MDW) to Asheville Regional Airport (AVL)plane plane MDW - AVL
    2. Drive from Asheville-Airport-AVL to Simpsonvillecar car
    6h 38m
    $108–512

Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP) flights

Calendar98Weekly Planes
Duration3h 7mAverage Duration
Ticket$96Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Simpsonville.ExpandLaunch map view
  • Distance: 608.5 mi
  • Duration: 4h 5m

What companies run services between Chicago, IL, USA and Simpsonville, SC, USA?

American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP) hourly. Alternatively, you can take a bus from Chicago Bus Station to Simpsonville via Atlanta Bus Station, Garnett Station, Doraville Station, Atlanta, and Taqueria Guadalajara - Greenville in around 21h 32m.

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