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How to get fromChicago to Simpsonvilleby plane, bus (Flixbus, Greyhound), train, bus, car or bus (Greyhound)

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There are 8 ways to get from Chicago to Simpsonville by plane, bus (Flixbus, Greyhound), train, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Greenville–Spartanburg International Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP)planeORD - GSP
    3h 59m
    $282–595

  2. Fly Chicago O'Hare International Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Asheville Regional Airport (AVL)planeORD - AVL
    2. Drive from Asheville-Airport-AVL to Simpsonvillecar
    4h 54m
    $68–342

  3. Bus via Atlanta

    1. Take the bus from Chicago Bus Station to Atlanta Bus StationbusFlixBus 2512 / ...
    2. Take the bus from Atlanta to Taqueria Guadalajara - GreenvillebusCharlotte
    20h 11m
    $164–407

  4. Train, bus

    1. Take the train from Chicago Union Station to Carytrain
    2. Take the train from Cary to Charlotte Amtrak Stationtrain
    3. Take the bus from Charlotte, NC to Greenville, SCbusNyc
    30h 57m
    $230–1,891

  5. Drive 680.5 mi

    1. Drive from Chicago to Simpsonvillecar680.5 mi
    12h 53m
    $125–180

  6. Fly Chicago Midway International Airport to Greenville–Spartanburg International Airport

    1. Fly from Chicago Midway International Airport (MDW) to Greenville–Spartanburg International Airport (GSP)planeMDW - GSP
    5h 47m
    $132–645

  7. Fly Chicago O'Hare International Airport to Columbia, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Columbia (CAE)planeORD - CAE
    2. Drive from Columbia-Airport-CAE to Simpsonvillecar
    5h 39m
    $118–580

  8. Bus

    1. Take the bus from Chicago Train Station to Atlanta Bus StationbusGreyhound US0100
    2. Take the bus from Atlanta to Taqueria Guadalajara - GreenvillebusCharlotte
    22h 14m
    $170–406

Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP) flights

Calendar102Weekly Planes
Duration3h 20mAverage Duration
Ticket$78Cheapest Price
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Questions & Answers

What companies run services between Chicago, IL, USA and Simpsonville, SC, USA?

American Airlines, United Airlines, and two other airlines fly from Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP) hourly. Alternatively, you can take a bus from Chicago Bus Station to Simpsonville via Atlanta Bus Station, Garnett Station, Lindbergh Center Station, Lindbergh Center Station - North Loop/Morosgo Dr, Shallowford Rd @ New Peachtree, Atlanta, and Taqueria Guadalajara - Greenville in around 20h 11m.

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