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How to get fromChicago to Simpsonvilleby plane, bus (Flixbus, Greyhound), train, bus, car or bus (Greyhound)

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There are 8 ways to get from Chicago to Simpsonville by plane, bus (Flixbus, Greyhound), train, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Greenville–Spartanburg International Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP)plane plane ORD - GSP
    4h
    $282–435

  2. Fly Chicago O'Hare International Airport to Asheville Regional Airport, drive

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Asheville Regional Airport (AVL)plane plane ORD - AVL
    2. Drive from Asheville-Airport-AVL to Simpsonvillecar car
    4h 54m
    $64–332

  3. Bus via Atlanta

    1. Take the bus from Chicago Bus Station to Atlanta Bus Stationbus bus FlixBus 2512 / ...
    2. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus Charlotte
    20h 11m
    $161–377

  4. Train, bus

    1. Take the train from Chicago Union Station to Carytrain train
    2. Take the train from Cary to Charlotte Amtrak Stationtrain train
    3. Take the bus from Charlotte, NC to Greenville, SCbus bus Nyc
    30h 57m
    $251–1,489

  5. Drive 680.6 mi

    1. Drive from Chicago to Simpsonvillecar car 680.6 mi
    12h 59m
    $125–180

  6. Fly Chicago Midway International Airport to Greenville–Spartanburg International Airport

    1. Fly from Chicago Midway International Airport (MDW) to Greenville–Spartanburg International Airport (GSP)plane plane MDW - GSP
    5h 41m
    $142–695

  7. Fly Chicago O'Hare International Airport to Columbia, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Columbia (CAE)plane plane ORD - CAE
    2. Drive from Columbia-Airport-CAE to Simpsonvillecar car
    5h 35m
    $128–680

  8. Bus

    1. Take the bus from Chicago Train Station to Atlanta Bus Stationbus bus Greyhound US0100
    2. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus Charlotte
    22h 14m
    $166–397

Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP) flights

Calendar93Weekly Planes
Duration3h 28mAverage Duration
Ticket$74Cheapest Price
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Questions & Answers

What companies run services between Chicago, IL, USA and Simpsonville, SC, USA?

American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Greenville–Spartanburg International Airport (GSP) hourly. Alternatively, you can take a bus from Chicago Bus Station to Simpsonville via Atlanta Bus Station, Garnett Station, Lindbergh Center Station, Lindbergh Center Station - North Loop/Morosgo Dr, Shallowford Rd @ New Peachtree, Atlanta, and Taqueria Guadalajara - Greenville in around 20h 11m.

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