There are 8 ways to get from Chicago to Sesser by train (Amtrak), bus, car, plane, or taxi
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train (Amtrak)
best- Take the train from Chicago Union Station to Du Quoin Amtrak StationSaluki / ...
5h 27m$71–137Drive 294.9 mi
cheapest- Drive from Chicago to Sesser294.9 mi
5h 1m$54–78Bus
- Take the bus from Chicago to El Rancherito - Mount VernonChicago / ...
6h 34m$107–232Fly Chicago O'Hare International Airport to Williamson County Regional Airport, taxi
- Fly from Chicago O'Hare International Airport (ORD) to Williamson County Regional Airport (MWA)ORD - MWA
- Take the taxi from Williamson County Regional Airport (MWA) to Sesser
3h 55m$122–250Fly Chicago O'Hare International Airport to Cape Girardeau Municipal Airport, drive
- Fly from Chicago O'Hare International Airport (ORD) to Cape Girardeau Municipal Airport (CGI)ORD - CGI
- Drive from Cape Girardeau Municipal Airport (CGI) to Sesser
5h 26m$102–198Fly Chicago O'Hare International Airport to Decatur Airport, drive
- Fly from Chicago O'Hare International Airport (ORD) to Decatur Airport (DEC)ORD - DEC
- Drive from Decatur Airport (DEC) to Sesser
5h 51m$64–305Fly Chicago Midway International Airport to Lambert–St. Louis International Airport, bus
- Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)MDW - STL
- Take the bus from St Louis Bus Station to Mount Vernon
6h 18m$148–673Fly Chicago O'Hare International Airport to Lambert–St. Louis International Airport, bus, taxi
- Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)ORD - STL
- Take the bus from St Louis Bus Station to Mount Vernon
- Take the taxi from Mount Vernon to Sesser
6h 43m$208–603
Chicago O'Hare International Airport (ORD) to Williamson County Regional Airport (MWA) flights
Questions & Answers
The cheapest way to get from Chicago to Sesser is to drive which costs $50 - $80 and takes 5h 1m.
The fastest way to get from Chicago to Sesser is to fly and taxi which takes 3h 55m and costs $120 - $250.
The distance between Chicago and Sesser is 307 miles. The road distance is 296.6 miles.
The best way to get from Chicago to Sesser without a car is to train which takes 5h 27m and costs $70 - $140.
It takes approximately 5h 27m to get from Chicago to Sesser, including transfers.
The best way to get from Chicago to Sesser is to train which takes 5h 27m and costs $70 - $140. Alternatively, you can bus, which costs $100 - $240 and takes 6h 34m.
Yes, the driving distance between Chicago to Sesser is 297 miles. It takes approximately 5h 1m to drive from Chicago to Sesser.
There are six+ hotels available in Sesser.
What companies run services between Chicago, IL, USA and Sesser, IL, USA?
Amtrak operates a train from Chicago Union Station to Du Quoin Amtrak Station twice daily. Tickets cost $35–95 and the journey takes 5h 2m. Alternatively, Tornado Bus Company operates a bus from Chicago to El Rancherito - Mount Vernon once daily. Tickets cost $60–170 and the journey takes 4h 25m.
- Website
- united.com
Flights from Chicago O'Hare International Airport to Decatur Airport
- Ave. Duration
- 1h 2m
- When
- Every day
- Estimated price
- $35–260
Flights from Chicago O'Hare International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 27m
- When
- Every day
- Estimated price
- $55–410
- Website
- aa.com
Flights from Chicago O'Hare International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 27m
- When
- Every day
- Estimated price
- $55–410
- Website
- southwest.com
Flights from Chicago Midway International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 13m
- When
- Every day
- Estimated price
- $70–550
- Website
- contouraviation.com
Flights from Chicago O'Hare International Airport to Williamson County Regional Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- $60–170
Flights from Chicago O'Hare International Airport to Cape Girardeau Municipal Airport
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- $85–170
- Website
- gojetairlines.com
Flights from Chicago O'Hare International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 34m
- When
- Every day
- Estimated price
- $55–410
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Chicago Union Station to Du Quoin Amtrak Station
- Ave. Duration
- 5h 2m
- Frequency
- Twice daily
- Estimated price
- $35–95
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 888 358 6762
- info@tornadobus.com
- Website
- tornadobus.com
Bus from Chicago to El Rancherito - Mount Vernon
- Ave. Duration
- 4h 25m
- Frequency
- Once daily
- Estimated price
- $60–170
- Schedules at
- tornadobus.com
- Adults 11-59
- $60–170
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from St Louis Bus Station to Mount Vernon
- Ave. Duration
- 1h 20m
- Frequency
- Once daily
- Estimated price
- $27–60
- Website
- https://www.greyhound.com/
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide







