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How to get fromChicago to Santeeby plane, bus (Flixbus, Greyhound), train (Amtrak), car, or bus

Find Transport to Santee

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There are 6 ways to get from Chicago to Santee by plane, bus (Flixbus, Greyhound), train (Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to San Diego International Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to San Diego International Airport (SAN)plane plane ORD - SAN
    7h 57m
    $108–500

  2. Bus

    1. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Phoenix Bus Stationbus bus
    3. Take the bus from Phoenix Bus Station to El Cajon Transit Centerbus bus
    45h 25m
    $352–556

  3. Train (Amtrak)

    1. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain train Southwest Chief
    2. Take the train from Fullerton Amtrak Station to San Diego Old Town Transportation Centertrain train Pacific Surfliner
    46h 59m
    $1,273–1,985

  4. Drive  2,074.7 mi

    1. Drive from Chicago to Santeecar car 2,074.7 mi
    32h 36m
    $379–547

  5. Fly Chicago Midway International Airport to San Diego International Airport

    1. Fly from Chicago Midway International Airport (MDW) to San Diego International Airport (SAN)plane plane MDW - SAN
    7h 47m
    $148–690

  6. Fly Chicago O'Hare International Airport to Los Angeles International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Los Angeles International Airport (LAX)plane plane ORD - LAX
    2. Take the bus from LAX Terminal 3 Shared Rides Stop to San Diegobus bus
    10h 56m
    $182–505

Chicago to Santee by bus and tram

Calendar7Weekly Services
Duration45h 25mAverage Duration
Ticket$352Cheapest Price
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Comparing Your Travel Options

Map of how to get from Chicago to Santee.ExpandLaunch map view
  • Distance: 1,766.1 mi
  • Duration: 7h 57m

What companies run services between Chicago, IL, USA and Santee, CA, USA?

American Airlines, United Airlines, and Alaska Airlines, Inc. fly from Chicago O'Hare International Airport (ORD) to San Diego International Airport (SAN) hourly. Alternatively, you can take a bus from Chicago Bus Station to Gillespie Field Station via St Louis Bus Station, Phoenix Bus Station, El Cajon Transit Center, and El Cajon Station in around 45h 25m.

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Want to know more about travelling around United States

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Need to know: Greyhound

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