Rome2Rio

How to get fromChicago to Santeeby plane, bus (Flixbus, Greyhound), train (Amtrak), car, train or bus

Find Transport to Santee

See all options

There are 8 ways to get from Chicago to Santee by plane, bus (Flixbus, Greyhound), train (Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago Midway International Airport to San Diego International Airport

    best
    1. Fly from Chicago Midway International Airport (MDW) to San Diego International Airport (SAN)plane plane MDW - SAN
    7h 38m
    $248–1,140

  2. Fly Chicago O'Hare International Airport to Los Angeles International Airport, bus

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Los Angeles International Airport (LAX)plane plane ORD - LAX
    2. Take the bus from LAX Terminal 3 Shared Rides Stop to San Diegobus bus
    10h 58m
    $172–585

  3. Bus

    1. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Phoenix Bus Stationbus bus
    3. Take the bus from Phoenix Bus Station to El Cajon Transit Centerbus bus
    45h 25m
    $346–669

  4. Train (Amtrak)

    1. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain train Southwest Chief
    2. Take the train from Fullerton Amtrak Station to San Diego Old Town Transportation Centertrain train Pacific Surfliner
    47h 2m
    $628–1,391

  5. Drive 2,074.7 mi

    1. Drive from Chicago to Santeecar car 2,074.7 mi
    32h 35m
    $379–547

  6. Fly Chicago O'Hare International Airport to San Diego International Airport

    1. Fly from Chicago O'Hare International Airport (ORD) to San Diego International Airport (SAN)plane plane ORD - SAN
    8h 12m
    $178–790

  7. Train to General Mitchell International Airport, fly to San Diego International Airport

    1. Take the train from Chicago Union Station to Milwaukeetrain train
    2. Fly from General Mitchell International Airport (MKE) to San Diego International Airport (SAN)plane plane MKE - SAN
    9h 14m
    $351–1,499

  8. Fly Chicago Midway International Airport to Los Angeles International Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Los Angeles International Airport (LAX)plane plane MDW - LAX
    2. Take the bus from LAX Terminal 3 Shared Rides Stop to San Diegobus bus
    10h 40m
    $202–795

Chicago to Santee by bus and tram

Calendar5Weekly Services
Duration45h 25mAverage Duration
Ticket$346Cheapest Price
See schedules

Questions & Answers

What companies run services between Chicago, IL, USA and Santee, CA, USA?

Southwest Airlines flies from Chicago Midway International Airport (MDW) to San Diego International Airport (SAN) every 4 hours. Alternatively, you can take a bus from Chicago Bus Station to Gillespie Field Station via St Louis Bus Station, Phoenix Bus Station, El Cajon Transit Center, and El Cajon Station in around 45h 25m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers

Trips from Chicago

Trips to Santee

Popular routes