Rome2Rio

How to get fromChicago to Santeeby plane, bus (Flixbus, Greyhound), train (Amtrak) or car

Find Transport to Santee

See all options

There are 5 ways to get from Chicago to Santee by plane, bus (Flixbus, Greyhound), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Chicago Midway International Airport

    best
    1. Fly from Chicago Midway International Airport (MDW) to San Diego International Airport (SAN)planeMDW - SAN
    7h 35m
    $188–840
  2. Fly from Chicago O'Hare International Airport

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to San Diego International Airport (SAN)planeORD - SAN
    7h 54m
    $94–430
  3. Bus

    1. Take the bus from Chicago Bus Station to St Louis Bus Stationbus
    2. Take the bus from St Louis Bus Station to Phoenix Bus Stationbus
    3. Take the bus from Phoenix Bus Station to El Cajon Transit Centerbus
    45h 35m
    $286–578
  4. Train (Amtrak)

    1. Take the train from Chicago Union Station to Fullerton Amtrak StationtrainSouthwest Chief
    2. Take the train from Fullerton Amtrak Station to San Diego Old Town Transportation CentertrainPacific Surfliner
    47h 2m
    $247–499
  5. Drive 2,074.7 mi

    1. Drive from Chicago to Santeecar2,074.7 mi
    32h 23m
    $379–547

Chicago to Santee by bus and tram

Calendar5Weekly Services
Duration45h 35mAverage Duration
Ticket$286Cheapest Price
See schedules

Questions & Answers

What companies run services between Chicago, IL, USA and Santee, CA, USA?

Southwest Airlines flies from Chicago Midway International Airport (MDW) to San Diego International Airport (SAN) every 4 hours. Alternatively, you can take a bus from Chicago Bus Station to Gillespie Field Station via St Louis Bus Station, Phoenix Bus Station, El Cajon Transit Center, and El Cajon Station in around 45h 35m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers