Rome2Rio

How to get fromChicago to Santa Anaby plane, train (Amtrak), bus (Flixbus, Greyhound, Amtrak), car or train

Find Transport to Santa Ana

See all options

There are 9 ways to get from Chicago to Santa Ana by plane, train (Amtrak), bus (Flixbus, Greyhound, Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to John Wayne Airport Orange County

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to John Wayne Airport Orange County (SNA)planeORD - SNA
    6h 29m
    $152–540

  2. Fly Chicago O'Hare International Airport to Los Angeles International Airport, train

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Los Angeles International Airport (LAX)planeORD - LAX
    2. Take the train from L.A. Union Station to Santa Anatrain
    9h 30m
    $106–389

  3. Train (Amtrak)

    1. Take the train from Chicago Union Station to Fullerton Amtrak StationtrainSouthwest Chief
    43h 51m
    $310–1,500

  4. Bus

    1. Take the bus from Chicago Bus Station to St Louis Bus Stationbus
    2. Take the bus from St Louis Bus Station to Los Angeles Union Stationbus
    3. Take the bus from Los Angeles to Santa Anabus
    2d

  5. Drive 2,009.9 mi

    1. Drive from Chicago to Santa Anacar2,009.9 mi
    31h 21m
    $367–530

  6. Fly Chicago Midway International Airport to Los Angeles International Airport, train

    1. Fly from Chicago Midway International Airport (MDW) to Los Angeles International Airport (LAX)planeMDW - LAX
    2. Take the train from L.A. Union Station to Santa Anatrain
    9h 10m
    $130–529

  7. Fly Chicago Midway International Airport to Long Beach Airport

    1. Fly from Chicago Midway International Airport (MDW) to Long Beach Airport (LGB)planeMDW - LGB
    9h 7m
    $152–667

  8. Fly Chicago Midway International Airport to San Diego International Airport, train

    1. Fly from Chicago Midway International Airport (MDW) to San Diego International Airport (SAN)planeMDW - SAN
    2. Take the train from San Diego Old Town Transportation Center to Santa Anatrain
    9h 9m
    $230–936

  9. Fly Chicago O'Hare International Airport to San Diego International Airport, train

    1. Fly from Chicago O'Hare International Airport (ORD) to San Diego International Airport (SAN)planeORD - SAN
    2. Take the train from San Diego Old Town Transportation Center to Santa Anatrain
    9h 33m
    $180–736

Chicago to Santa Ana by train and bus (Amtrak)

Calendar13Weekly Services
Duration43h 51mAverage Duration
Ticket$310Cheapest Price
See schedules

Questions & Answers

What companies run services between Chicago, IL, USA and Santa Ana, CA, USA?

American Airlines, United Airlines, and two other airlines fly from Chicago O'Hare International Airport (ORD) to John Wayne Airport Orange County (SNA) every 2 hours. Alternatively, Amtrak operates a train from Chicago Union Station to Fullerton Amtrak Station twice daily. Tickets cost $300–1,500 and the journey takes 42h 44m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers

Trips from Chicago

Trips to Santa Ana

Popular routes