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How to get fromChicago to Santa Anaby plane, train (Amtrak), bus (Flixbus, Greyhound, Amtrak), car, or train

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There are 9 ways to get from Chicago to Santa Ana by plane, train (Amtrak), bus (Flixbus, Greyhound, Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to John Wayne Airport Orange County

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to John Wayne Airport Orange County (SNA)plane plane ORD - SNA
    6h 21m
    $252–690

  2. Fly Chicago O'Hare International Airport to Los Angeles International Airport, train

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Los Angeles International Airport (LAX)plane plane ORD - LAX
    2. Take the train from Los Angeles to Santa Anatrain train
    8h 56m
    $128–470

  3. Train (Amtrak)

    1. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain train Southwest Chief
    43h 51m
    $634–1,358

  4. Bus

    1. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Los Angeles Union Stationbus bus
    3. Take the bus from Los Angeles to Santa Anabus bus
    2d 1h
    $363–738

  5. Drive 2,009.9 mi

    1. Drive from Chicago to Santa Anacar car 2,009.9 mi
    31h 33m
    $367–530

  6. Fly Chicago Midway International Airport to Los Angeles International Airport, train

    1. Fly from Chicago Midway International Airport (MDW) to Los Angeles International Airport (LAX)plane plane MDW - LAX
    2. Take the train from Los Angeles to Santa Anatrain train
    8h 30m
    $168–740

  7. Fly Chicago Midway International Airport to Long Beach Airport

    1. Fly from Chicago Midway International Airport (MDW) to Long Beach Airport (LGB)plane plane MDW - LGB
    8h 52m
    $206–912

  8. Fly Chicago Midway International Airport to San Diego International Airport, train

    1. Fly from Chicago Midway International Airport (MDW) to San Diego International Airport (SAN)plane plane MDW - SAN
    2. Take the train from San Diego to Santa Anatrain train
    9h 6m
    $290–1,270

  9. Fly Chicago O'Hare International Airport to San Diego International Airport, train

    1. Fly from Chicago O'Hare International Airport (ORD) to San Diego International Airport (SAN)plane plane ORD - SAN
    2. Take the train from San Diego to Santa Anatrain train
    9h 37m
    $200–820

Chicago to Santa Ana by train and bus (Amtrak)

Calendar7Weekly Services
Duration43h 51mAverage Duration
Ticket$634Cheapest Price
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Questions & Answers

What companies run services between Chicago, IL, USA and Santa Ana, CA, USA?

American Airlines, United Airlines, and Southwest Airlines fly from Chicago O'Hare International Airport (ORD) to John Wayne Airport Orange County (SNA) every 2 hours. Alternatively, Amtrak operates a train from Chicago Union Station to Fullerton Amtrak Station once daily. Tickets cost $600–1,400 and the journey takes 42h 44m.

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