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How to get fromChicago to Santa Anaby plane, train (Amtrak), bus (Flixbus, Greyhound, Amtrak), car or train

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There are 9 ways to get from Chicago to Santa Ana by plane, train (Amtrak), bus (Flixbus, Greyhound, Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to John Wayne Airport Orange County

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to John Wayne Airport Orange County (SNA)plane plane ORD - SNA
    6h 31m
    $162–790

  2. Fly Chicago O'Hare International Airport to Los Angeles International Airport, train

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Los Angeles International Airport (LAX)plane plane ORD - LAX
    2. Take the train from L.A. Union Station to Santa Anatrain train
    9h 2m
    $118–460

  3. Train (Amtrak)

    1. Take the train from Chicago Union Station to Fullerton Amtrak Stationtrain train Southwest Chief
    43h 51m
    $500–1,123

  4. Bus

    1. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Los Angeles Union Stationbus bus
    3. Take the bus from Los Angeles to Santa Anabus bus
    2d
    $357–681

  5. Drive 2,009.9 mi

    1. Drive from Chicago to Santa Anacar car 2,009.9 mi
    31h 31m
    $367–530

  6. Fly Chicago Midway International Airport to Long Beach Airport

    1. Fly from Chicago Midway International Airport (MDW) to Long Beach Airport (LGB)plane plane MDW - LGB
    9h 2m
    $176–812

  7. Fly Chicago Midway International Airport to Los Angeles International Airport, train

    1. Fly from Chicago Midway International Airport (MDW) to Los Angeles International Airport (LAX)plane plane MDW - LAX
    2. Take the train from L.A. Union Station to Santa Anatrain train
    8h 54m
    $138–630

  8. Fly Chicago Midway International Airport to San Diego International Airport, train

    1. Fly from Chicago Midway International Airport (MDW) to San Diego International Airport (SAN)plane plane MDW - SAN
    2. Take the train from San Diego Old Town Transportation Center to Santa Anatrain train
    9h 14m
    $292–1,250

  9. Fly Chicago O'Hare International Airport to San Diego International Airport, train

    1. Fly from Chicago O'Hare International Airport (ORD) to San Diego International Airport (SAN)plane plane ORD - SAN
    2. Take the train from San Diego Old Town Transportation Center to Santa Anatrain train
    9h 37m
    $192–850

Chicago to Santa Ana by train and bus (Amtrak)

Calendar13Weekly Services
Duration43h 51mAverage Duration
Ticket$500Cheapest Price
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Questions & Answers

What companies run services between Chicago, IL, USA and Santa Ana, CA, USA?

American Airlines, United Airlines, and two other airlines fly from Chicago O'Hare International Airport (ORD) to John Wayne Airport Orange County (SNA) every 2 hours. Alternatively, Amtrak operates a train from Chicago Union Station to Fullerton Amtrak Station twice daily. Tickets cost $490–1,200 and the journey takes 42h 44m.

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