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How to get fromChicago to Opelousasby plane, taxi, train (Amtrak), bus (Flixbus, Greyhound), car or bus

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There are 7 ways to get from Chicago to Opelousas by plane, taxi, train (Amtrak), bus (Flixbus, Greyhound), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago Midway International Airport to Lafayette Regional Airport, taxi

    best
    1. Fly from Chicago Midway International Airport (MDW) to Lafayette Regional Airport (LFT)plane plane MDW - LFT
    2. Take the taxi from Lafayette Regional Airport (LFT) to Opelousastaxi taxi
    6h 42m
    $124–618

  2. Fly Chicago O'Hare International Airport to Lafayette Regional Airport, taxi

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Lafayette Regional Airport (LFT)plane plane ORD - LFT
    2. Take the taxi from Lafayette Regional Airport (LFT) to Opelousastaxi taxi
    7h 5m
    $88–418

  3. Train (Amtrak)

    1. Take the train from Chicago Union Station to New Orleans Union Passenger Terminaltrain train City of New Orleans
    2. Take the train from New Orleans Union Passenger Terminal to Lafayette Amtrak Stationtrain train Sunset Limited
    24h 30m
    $167–278

  4. Bus

    1. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Baton Rouge Bus Stationbus bus
    3. Take the bus from Baton Rouge Bus Station to Opelousasbus bus
    28h
    $144–302

  5. Drive 920.9 mi

    1. Drive from Chicago to Opelousascar car 920.9 mi
    16h 51m
    $169–243

  6. Fly Chicago Midway International Airport to Louis Armstrong New Orleans International Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Louis Armstrong New Orleans International Airport (MSY)plane plane MDW - MSY
    2. Take the bus from New Orleans International Airport to Opelousasbus bus
    9h 7m
    $134–558

  7. Fly Chicago O'Hare International Airport to Louis Armstrong New Orleans International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Louis Armstrong New Orleans International Airport (MSY)plane plane ORD - MSY
    2. Take the bus from New Orleans International Airport to Opelousasbus bus
    9h 30m
    $134–438

Chicago Midway International Airport (MDW) to Lafayette Regional Airport (LFT) flights

Calendar28Weekly Planes
Duration5h 44mAverage Duration
Ticket$111Cheapest Price
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Questions & Answers

What companies run services between Chicago, IL, USA and Opelousas, LA, USA?

You can take a train from Chicago Union Station to Opelousas via New Orleans Union Passenger Terminal and Lafayette Amtrak Station in around 24h 30m. Alternatively, you can take a bus from Chicago Bus Station to Opelousas via St Louis Bus Station, Baton Rouge Bus Station, and Opelousas in around 28h.

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Need to know: Greyhound

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