There are 7 ways to get from Chicago to Murrells Inlet by plane, bus (Flixbus, Greyhound), train, car, bus (Greyhound), or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Chicago Midway International Airport
best- Fly from Chicago Midway International Airport (MDW) to Myrtle Beach (MYR)MDW - MYR
3h 48m$122–495Bus
- Take the bus from Chicago Bus Station to Atlanta Bus StationFlixBus 2512 / ...
- Take the bus from Atlanta to Myrtle Beach, SCAtlanta
23h 16m$157–376Train, drive (Amtrak)
- Take the train from Chicago Union Station to Petersburg Amtrak Station
- Take the train from Petersburg Amtrak Station to Kingstree Amtrak Station
- Drive from Kingstree Amtrak Station to Murrells Inlet
29h 4m$235–454Drive 903.4 mi
- Drive from Chicago to Murrells Inlet903.4 mi
16h 34m$165–239Fly from Chicago O'Hare International Airport
- Fly from Chicago O'Hare International Airport (ORD) to Myrtle Beach (MYR)ORD - MYR
4h 11m$128–365Bus via Madison
- Take the bus from Chicago Train Station to Atlanta Bus Station
- Take the bus from Atlanta, GA to Madison, GA
- Take the bus from Madison to Myrtle Beach Bus Station
26h 31m$191–398Train, bus
- Take the train from Chicago Union Station to Petersburg Amtrak Station
- Take the train from Petersburg Amtrak Station to Fayetteville Amtrak Station
- Take the bus from Fayetteville Bus Station to Florence Bus Station
- Take the bus from Florence Bus Station to Myrtle Beach Bus Station
30h 1m$328–712
Chicago Midway International Airport (MDW) to Myrtle Beach (MYR) flights
Questions & Answers
The cheapest way to get from Chicago to Murrells Inlet is to drive which costs $160 - $240 and takes 16h 34m.
The fastest way to get from Chicago to Murrells Inlet is to fly which takes 3h 48m and costs $120 - $500.
The distance between Chicago and Murrells Inlet is 766 miles. The road distance is 908.7 miles.
The best way to get from Chicago to Murrells Inlet without a car is to bus which takes 23h 16m and costs $150 - $380.
It takes approximately 3h 48m to get from Chicago to Murrells Inlet, including transfers.
The best way to get from Chicago to Murrells Inlet is to fly which takes 3h 48m and costs $120 - $500. Alternatively, you can bus, which costs $150 - $380 and takes 23h 16m.
Murrells Inlet is 1h ahead of Chicago. It is currently 4:26 PM in Chicago and 5:26 PM in Murrells Inlet.
Yes, the driving distance between Chicago to Murrells Inlet is 909 miles. It takes approximately 16h 34m to drive from Chicago to Murrells Inlet.
There are 2761+ hotels available in Murrells Inlet.
What companies run services between Chicago, IL, USA and Murrells Inlet, SC, USA?
Southwest Airlines and Delta fly from Chicago Midway International Airport (MDW) to Myrtle Beach (MYR) 3 times a day. Alternatively, you can take a bus from Chicago Bus Station to Murrells Inlet via Atlanta Bus Station, Atlanta, and Myrtle Beach, SC in around 23h 16m.
Transport is disrupted due to the Russia-Ukraine war. Read more
- Website
- aa.com
Flights from Chicago O'Hare International Airport to Myrtle Beach
- Ave. Duration
- 2h 5m
- When
- Every day
- Estimated price
- $65–350
Flights from Chicago O'Hare International Airport to Myrtle Beach via Charlotte
- Ave. Duration
- 4h 15m
- When
- Every day
- Estimated price
- $65–350
- Website
- southwest.com
Flights from Chicago Midway International Airport to Myrtle Beach
- Ave. Duration
- 1h 55m
- When
- Every day
- Estimated price
- $80–440
Flights from Chicago Midway International Airport to Myrtle Beach via Nashville
- Ave. Duration
- 4h 35m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $90–470
Flights from Chicago O'Hare International Airport to Myrtle Beach
- Ave. Duration
- 2h 10m
- When
- Saturday
- Estimated price
- $65–350
Flights from Chicago O'Hare International Airport to Myrtle Beach via Nashville
- Ave. Duration
- 4h 45m
- When
- Monday, Tuesday, Wednesday, Friday, Saturday, and Sunday
- Estimated price
- $70–370
- Website
- delta.com
Flights from Chicago Midway International Airport to Myrtle Beach via Atlanta
- Ave. Duration
- 4h 8m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $90–480
Flights from Chicago O'Hare International Airport to Myrtle Beach via Atlanta
- Ave. Duration
- 4h 27m
- When
- Every day
- Estimated price
- $70–380
- Website
- united.com
Flights from Chicago O'Hare International Airport to Myrtle Beach
- Ave. Duration
- 2h 18m
- When
- Every day
- Estimated price
- $65–350
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Chicago Union Station to Petersburg Amtrak Station
- Ave. Duration
- 20h 56m
- Frequency
- Once daily
- Estimated price
- $180–320
- Website
- https://www.amtrak.com/home.html
Train from Petersburg Amtrak Station to Kingstree Amtrak Station
- Ave. Duration
- 5h 36m
- Frequency
- Twice daily
- Estimated price
- $35–120
- Website
- https://www.amtrak.com/home.html
- Coach Seat - Advance Purchase
- $35–80
- Coach Seat short notice purchase
- $40–120
- Business - advance purchase
- $50–250
- Business Class
- $90–300
Train from Petersburg Amtrak Station to Fayetteville Amtrak Station
- Ave. Duration
- 2h 54m
- Frequency
- Twice daily
- Estimated price
- $50–150
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Chicago Bus Station to Atlanta Bus Station
- Ave. Duration
- 14h 25m
- Frequency
- 3 times a day
- Estimated price
- $85–160
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Chicago Bus Station to Atlanta Bus Station
- Ave. Duration
- 16h 15m
- Frequency
- 4 times a day
- Estimated price
- $75–150
- Website
- https://www.greyhound.com/
Bus from Atlanta to Myrtle Beach, SC
- Ave. Duration
- 8h 5m
- Frequency
- Once daily
- Estimated price
- $35–170
- Website
- https://www.greyhound.com/
Bus from Chicago Train Station to Atlanta Bus Station
- Ave. Duration
- 16h 15m
- Frequency
- Twice daily
- Estimated price
- $75–160
- Website
- https://www.greyhound.com/
Bus from Atlanta, GA to Madison, GA
- Ave. Duration
- 1h 5m
- Frequency
- Once daily
- Estimated price
- $25–55
- Website
- https://www.greyhound.com/
Bus from Madison to Myrtle Beach Bus Station
- Ave. Duration
- 6h 55m
- Frequency
- Once daily
- Estimated price
- $45–95
- Website
- https://www.greyhound.com/
Bus from Fayetteville Bus Station to Florence Bus Station
- Ave. Duration
- 1h 30m
- Frequency
- Once daily
- Estimated price
- $28–60
- Website
- https://www.greyhound.com/
Bus from Florence Bus Station to Myrtle Beach Bus Station
- Ave. Duration
- 1h 20m
- Frequency
- Once daily
- Estimated price
- $16–19
- Website
- https://www.greyhound.com/
- Phone
- +1 404-591-2750
- info@southeasternstages.com
- Website
- southeasternstages.com
Bus from Atlanta to Myrtle Beach, SC
- Ave. Duration
- 7h 30m
- Frequency
- Once daily
- Estimated price
- $90–110
- Schedules at
- southeasternstages.com
Bus from Atlanta, GA to Madison, GA
- Ave. Duration
- 1h
- Frequency
- Once daily
- Estimated price
- $23–95
- Schedules at
- southeasternstages.com
Bus from Fayetteville Bus Station to Florence Bus Station
- Ave. Duration
- 1h 40m
- Frequency
- Once daily
- Estimated price
- $29–95
- Schedules at
- southeasternstages.com
Bus from Florence Bus Station to Myrtle Beach Bus Station
- Ave. Duration
- 1h 25m
- Frequency
- Once daily
- Estimated price
- $25–95
- Schedules at
- southeasternstages.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide









