There are 6 ways to get from Chicago to Murphysboro by train (Amtrak), bus (Flixbus, Amtrak), car, plane, or taxi
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train (Amtrak)
best- Take the train from Chicago Union Station to Carbondaletrain Saluki / ...
5h 40m$120–220Drive 331.7 mi
cheapest- Drive from Chicago to Murphysborocar 331.7 mi
5h 43m$61–88Bus
- Take the bus from Chicago Bus Station to St Louis Bus Stationbus FlixBus 2510 / ...
- Take the bus from St. Louis to Carbondalebus Amtrak Thruway Connecting Service
9h 5m$80–150Fly to Williamson County Regional Airport
- Fly from Chicago O'Hare International Airport (ORD) to Williamson County Regional Airport (MWA)plane ORD - MWA
3h 35m$132–275Fly to Cape Girardeau Municipal Airport, taxi
- Fly from Chicago O'Hare International Airport (ORD) to Cape Girardeau Municipal Airport (CGI)plane ORD - CGI
- Take the taxi from Cape Girardeau Municipal Airport (CGI) to Murphysborotaxi
4h 40m$178–355Fly to Barkley Regional Airport, drive
- Fly from Chicago O'Hare International Airport (ORD) to Barkley Regional Airport (PAH)plane ORD - PAH
- Drive from Barkley Regional Airport (PAH) to Murphysborocar
4h 44m$66–336
Chicago O'Hare International Airport (ORD) to Williamson County Regional Airport (MWA) flights
Questions & Answers
The cheapest way to get from Chicago to Murphysboro is to drive which costs $60 - $90 and takes 5h 43m.
The fastest way to get from Chicago to Murphysboro is to fly which takes 3h 35m and costs $130 - $280.
No, there is no direct bus from Chicago station to Murphysboro. However, there are services departing from Chicago Bus Station and arriving at Carbondale via St. Louis. The journey, including transfers, takes approximately 9h 5m.
No, there is no direct train from Chicago station to Murphysboro. However, there are services departing from Chicago Union Station and arriving at Carbondale via . The journey, including transfers, takes approximately 5h 40m.
The distance between Chicago and Murphysboro is 318 miles. The road distance is 333.7 miles.
The best way to get from Chicago to Murphysboro without a car is to train which takes 5h 40m and costs $120 - $220.
It takes approximately 5h 40m to get from Chicago to Murphysboro, including transfers.
Chicago to Murphysboro bus services, operated by Flixbus USA, depart from Chicago Bus Station.
Chicago to Murphysboro train services, operated by Amtrak, depart from Chicago Union Station.
The best way to get from Chicago to Murphysboro is to train which takes 5h 40m and costs $120 - $220. Alternatively, you can bus, which costs $80 - $150 and takes 9h 5m, you could also fly, which costs $130 - $280 and takes 3h 35m.
What companies run services between Chicago, IL, USA and Murphysboro, IL, USA?
Amtrak operates a train from Chicago Union Station to Carbondale 3 times a day. Tickets cost $100–200 and the journey takes 5h 30m. Alternatively, you can take a bus from Chicago Bus Station to Murphysboro via St Louis Bus Station, St. Louis, and Carbondale in around 9h 5m.
- Website
- contouraviation.com
Flights from Chicago O'Hare International Airport to Williamson County Regional Airport
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- $85–210
Flights from Chicago O'Hare International Airport to Cape Girardeau Municipal Airport
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- $65–210
- Website
- aa.com
Flights from Chicago O'Hare International Airport to Williamson County Regional Airport
- Ave. Duration
- 1h 23m
- When
- Every day
- Estimated price
- $45–290
- Website
- united.com
Flights from Chicago O'Hare International Airport to Barkley Regional Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- $50–310
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Chicago Union Station to Carbondale
- Ave. Duration
- 5h 30m
- Frequency
- 3 times a day
- Estimated price
- $100–200
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Chicago Bus Station to St Louis Bus Station
- Ave. Duration
- 5h 55m
- Frequency
- Twice daily
- Estimated price
- $45–80
- Schedules at
- flixbus.com
Bus from St. Louis to Carbondale
- Ave. Duration
- 1h 50m
- Frequency
- 5 times a week
- Estimated price
- $14–24
- Schedules at
- flixbus.com
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from St. Louis to Carbondale
- Ave. Duration
- 2h
- Frequency
- Once daily
- Estimated price
- $30–50
- Website
- https://www.amtrak.com/home.html
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More Questions & Answers
Chicago to Murphysboro bus services, operated by Flixbus USA, arrive at St Louis Bus Station.
Chicago to Murphysboro train services, operated by Amtrak, arrive at Carbondale station.
Yes, the driving distance between Chicago to Murphysboro is 334 miles. It takes approximately 5h 43m to drive from Chicago to Murphysboro.
Book your Chicago to Murphysboro train tickets online with Omio.
Book your Chicago to Murphysboro bus tickets online with Omio.
There are 17+ hotels available in Murphysboro.