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How to get fromChicago to Murphysboroby train (Amtrak), bus (Flixbus, Amtrak), car, plane, or taxi

Find Transport to Murphysboro

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There are 6 ways to get from Chicago to Murphysboro by train (Amtrak), bus (Flixbus, Amtrak), car, plane, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Chicago Union Station to Carbondaletrain train Saluki / ...
    5h 40m
    $115–218

  2. Fly to Barkley Regional Airport, drive

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Barkley Regional Airport (PAH)plane plane ORD - PAH
    2. Drive from Barkley Regional Airport (PAH) to Murphysborocar car
    4h 44m
    $60–326

  3. Bus

    1. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus 2510 / ...
    2. Take the bus from St. Louis to Carbondalebus bus Amtrak Thruway Connecting Service
    9h 5m
    $74–143

  4. Drive 331.7 mi

    1. Drive from Chicago to Murphysborocar car 331.7 mi
    5h 43m
    $61–88

  5. Fly to Williamson County Regional Airport

    1. Fly from Chicago O'Hare International Airport (ORD) to Williamson County Regional Airport (MWA)plane plane ORD - MWA
    3h 35m
    $142–275

  6. Fly to Cape Girardeau Municipal Airport, taxi

    1. Fly from Chicago O'Hare International Airport (ORD) to Cape Girardeau Municipal Airport (CGI)plane plane ORD - CGI
    2. Take the taxi from Cape Girardeau Municipal Airport (CGI) to Murphysborotaxi taxi
    4h 40m
    $188–355

Chicago O'Hare International Airport (ORD) to Williamson County Regional Airport (MWA) flights

Calendar19Weekly Planes
Duration1h 31mAverage Duration
Ticket$42Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Murphysboro.ExpandLaunch map view
  • Distance: 316.5 mi
  • Duration: 5h 40m

What companies run services between Chicago, IL, USA and Murphysboro, IL, USA?

Amtrak operates a train from Chicago Union Station to Carbondale 3 times a day. Tickets cost $95–200 and the journey takes 5h 30m. Alternatively, you can take a bus from Chicago Bus Station to Murphysboro via St Louis Bus Station, St. Louis, and Carbondale in around 9h 5m.

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