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How to get fromChicago to Murphysboroby train (Amtrak), bus (Flixbus), car, plane, taxi or bus

Find Transport to Murphysboro

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There are 7 ways to get from Chicago to Murphysboro by train (Amtrak), bus (Flixbus), car, plane, taxi, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Chicago Union Station to CarbondaletrainCity of New Orleans / ...
    5h 26m
    $65–172

  2. Drive 331.7 mi

    cheapest
    1. Drive from Chicago to Murphysborocar331.7 mi
    5h 40m
    $61–88

  3. Bus (Flixbus)

    1. Take the bus from Chicago Bus Station to Carbondale Intermodal StationbusFlixBus N2521
    9h 15m
    $74–154

  4. Fly Chicago O'Hare International Airport to Williamson County Regional Airport

    1. Fly from Chicago O'Hare International Airport (ORD) to Williamson County Regional Airport (MWA)planeORD - MWA
    3h 44m
    $108–235

  5. Fly Chicago O'Hare International Airport to Cape Girardeau Municipal Airport, taxi

    1. Fly from Chicago O'Hare International Airport (ORD) to Cape Girardeau Municipal Airport (CGI)planeORD - CGI
    2. Take the taxi from Cape Girardeau Municipal Airport (CGI) to Murphysborotaxi
    4h 37m
    $178–315

  6. Fly Chicago O'Hare International Airport to Barkley Regional Airport, drive

    1. Fly from Chicago O'Hare International Airport (ORD) to Barkley Regional Airport (PAH)planeORD - PAH
    2. Drive from Barkley Regional Airport (PAH) to Murphysborocar
    4h 42m
    $256–1,725

  7. Fly Chicago Midway International Airport to Lambert–St. Louis International Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)planeMDW - STL
    2. Take the bus from St. Louis to Carbondalebus
    6h 35m
    $120–651

Chicago O'Hare International Airport (ORD) to Williamson County Regional Airport (MWA) flights

Calendar13Weekly Planes
Duration1h 30mAverage Duration
Ticket$60Cheapest Price
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Questions & Answers

What companies run services between Chicago, IL, USA and Murphysboro, IL, USA?

Amtrak operates a train from Chicago Union Station to Carbondale 3 times a day. Tickets cost $45–150 and the journey takes 5h 16m. Alternatively, Flixbus USA operates a bus from Chicago Bus Station to Carbondale Intermodal Station once daily. Tickets cost $55–140 and the journey takes 9h 5m.

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