There are 7 ways to get from Chicago to Mesa by plane, train, bus, bus (Greyhound), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Chicago Midway International Airport
best- Fly from Chicago Midway International Airport (MDW) to Phoenix (PHX)plane MDW - PHX
6h 19m$154–707Train, bus via Flagstaff
- Take the train from Chicago Union Station to Flagstafftrain Southwest Chief
- Take the bus from Flagstaff Train Station to Tempebus FlixBus 2047
36h 30m$951–1,460Bus (Greyhound)
- Take the bus from Chicago Bus Station to Denver Union Stationbus
- Take the bus from Denver Union Station to El Paso Bus Stationbus
- Take the bus from El Paso Bus Station to Phoenix Sky Harbor Airport/44th Street Sky Train Stationbus
2d$375–573Drive 1,688.8 mi
- Drive from Chicago to Mesacar 1,688.8 mi
29h 38m$279–403Fly from Chicago O'Hare International Airport
- Fly from Chicago O'Hare International Airport (ORD) to Phoenix (PHX)plane ORD - PHX
6h 33m$164–347Train to General Mitchell International Airport, fly
- Take the train from Chicago Union Station to Milwaukeetrain
- Fly from General Mitchell International Airport (MKE) to Phoenix (PHX)plane MKE - PHX
7h 43m$191–788Train, bus
- Take the train from Chicago Union Station to Tucson Amtrak Stationtrain Texas Eagle
- Take the bus from Tucson Downtown to Tempebus FlixBus 2047 / ...
2d 10h$1,238–1,898
Chicago to Mesa by train and bus
Comparing Your Travel Options
The cheapest way to get from Chicago to Mesa is to fly which costs $160 - $350 and takes 6h 33m.
The fastest way to get from Chicago to Mesa is to fly which takes 6h 19m and costs $150 - $750.
No, there is no direct bus from Chicago station to Mesa. However, there are services departing from Chicago Bus Station and arriving at University Dr & Mesa Dr via Denver Union Station, El Paso Bus Station, Phoenix Sky Harbor Airport/44th Street Sky Train Station and University Dr & Rural Rd. The journey, including transfers, takes approximately 2 days 0h.
The distance between Chicago and Mesa is 1473 miles. The road distance is 1698.7 miles.
The best way to get from Chicago to Mesa without a car is to train and bus via Flagstaff which takes 36h 30m and costs $950 - $1,500.
It takes approximately 6h 19m to get from Chicago to Mesa, including transfers.
Chicago to Mesa bus services, operated by Greyhound USA, depart from Chicago Bus Station.
The best way to get from Chicago to Mesa is to fly which takes 6h 19m and costs $150 - $750. Alternatively, you can bus, which costs $370 - $600 and takes 2 days 0h.
Chicago to Mesa bus services, operated by Greyhound USA, arrive at Denver Union Station.
Mesa is 1h behind Chicago. It is currently 9:24 AM in Chicago and 8:24 AM in Mesa.
What companies run services between Chicago, IL, USA and Mesa, AZ, USA?
Southwest Airlines flies from Chicago Midway International Airport (MDW) to Phoenix (PHX) every 3 hours. Alternatively, you can take a bus from Chicago Bus Station to University Dr & Mesa Dr via Denver Union Station, El Paso Bus Station, Phoenix Sky Harbor Airport/44th Street Sky Train Station, Tempe, and University Dr & Rural Rd in around 2d.
- Website
- southwest.com
Flights from Chicago Midway International Airport to Phoenix
- Ave. Duration
- 3h 54m
- When
- Every day
- Estimated price
- $150–700
Flights from Chicago Midway International Airport to Phoenix via Omaha
- Ave. Duration
- 5h 45m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $150–700
Flights from Chicago Midway International Airport to Phoenix via Kansas City
- Ave. Duration
- 5h 30m
- When
- Saturday, Monday, Thursday, Friday, and Sunday
- Estimated price
- $150–700
Flights from Chicago Midway International Airport to Phoenix via St. Louis
- Ave. Duration
- 5h 45m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $150–700
Flights from General Mitchell International Airport to Phoenix
- Ave. Duration
- 3h 53m
- When
- Every day
- Estimated price
- $140–700
Flights from General Mitchell International Airport to Phoenix via Denver
- Ave. Duration
- 5h 45m
- When
- Saturday, Monday, Thursday, Tuesday, and Wednesday
- Estimated price
- $150–700
- Website
- aa.com
Flights from Chicago O'Hare International Airport to Phoenix
- Ave. Duration
- 4h 4m
- When
- Every day
- Estimated price
- $85–400
Flights from Chicago O'Hare International Airport to Phoenix via Des Moines
- Ave. Duration
- 5h 45m
- When
- Every day
- Estimated price
- $85–400
Flights from General Mitchell International Airport to Phoenix
- Ave. Duration
- 3h 55m
- When
- Every day
- Estimated price
- $140–700
- Website
- united.com
Flights from Chicago O'Hare International Airport to Phoenix
- Ave. Duration
- 4h 3m
- When
- Every day
- Estimated price
- $85–400
Flights from Chicago O'Hare International Airport to Phoenix via Denver
- Ave. Duration
- 5h 48m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $90–410
- Website
- flyfrontier.com
Flights from Chicago O'Hare International Airport to Phoenix
- Ave. Duration
- 4h 10m
- When
- Monday, Tuesday, Wednesday, Friday, and Saturday
- Estimated price
- $190–370
- Website
- suncountry.com
Flights from General Mitchell International Airport to Phoenix
- Ave. Duration
- 3h 56m
- When
- Thursday
- Estimated price
- $140–700
- Website
- delta.com
Flights from General Mitchell International Airport to Phoenix via Minneapolis
- Ave. Duration
- 5h 55m
- When
- Every day
- Estimated price
- $150–700
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Chicago Union Station to Flagstaff
- Ave. Duration
- 31h 44m
- Frequency
- Once daily
- Estimated price
- $900–1,500
- Website
- Amtrak
Train from Chicago Union Station to Milwaukee
- Ave. Duration
- 1h 29m
- Frequency
- Every 4 hours
- Estimated price
- $45–75
- Website
- Amtrak
Train from Chicago Union Station to Tucson Amtrak Station
- Ave. Duration
- 2d 6h
- Frequency
- 3 times a week
- Estimated price
- $1,200–1,900
- Website
- Amtrak
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Flagstaff Train Station to Tempe
- Ave. Duration
- 2h 50m
- Frequency
- 5 times a week
- Estimated price
- $25–40
- Schedules at
- Flixbus USA
Bus from Tucson Downtown to Tempe
- Ave. Duration
- 1h 50m
- Frequency
- 5 times a day
- Estimated price
- $18–27
- Schedules at
- Flixbus USA
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- Greyhound
Bus from Chicago Bus Station to Denver Union Station
- Ave. Duration
- 21h 35m
- Frequency
- Once daily
- Estimated price
- $180–270
- Website
- Greyhound
Bus from Denver Union Station to El Paso Bus Station
- Ave. Duration
- 13h 45m
- Frequency
- 5 times a week
- Estimated price
- $120–190
- Website
- Greyhound
Bus from El Paso Bus Station to Phoenix Sky Harbor Airport/44th Street Sky Train Station
- Ave. Duration
- 9h 5m
- Frequency
- Once daily
- Estimated price
- $70–110
- Website
- Greyhound
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
Booking & Getting There
Yes, the driving distance between Chicago to Mesa is 1699 miles. It takes approximately 29h 38m to drive from Chicago to Mesa.
Book your Chicago to Mesa bus tickets online with Omio.
There are 2818+ hotels available in Mesa.















