There are 7 ways to get from Chicago to Mesa by plane, train, bus, bus (Flixbus, Greyhound), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Chicago O'Hare International Airport
best- Fly from Chicago O'Hare International Airport (ORD) to Phoenix (PHX)plane ORD - PHX
6h 37m$274–657Bus
cheapest- Take the bus from Chicago Bus Station to St Louis Bus Stationbus FlixBus N2521 / ...
- Take the bus from St Louis Bus Station to Phoenix Bus Stationbus Greyhound US1210
40h 33m$156–596Train, bus via Flagstaff
- Take the train from Chicago Union Station to Flagstafftrain Southwest Chief
- Take the bus from Flagstaff Train Station to Phoenix Sky Harbor Airport/44th Street Sky Train Stationbus FlixBus 2047
35h 59m$198–420Drive 1,688.8 mi
- Drive from Chicago to Mesacar 1,688.8 mi
29h 41m$309–446Fly from Chicago Midway International Airport
- Fly from Chicago Midway International Airport (MDW) to Phoenix (PHX)plane MDW - PHX
6h 22m$174–857Train to General Mitchell International Airport, fly
- Take the train from Chicago Union Station to Milwaukeetrain
- Fly from General Mitchell International Airport (MKE) to Phoenix (PHX)plane MKE - PHX
7h 49m$246–1,218Train, bus
- Take the train from Chicago Union Station to Tucson Amtrak Stationtrain Texas Eagle
- Take the bus from Tucson Downtown to Tempebus FlixBus 2047 / ...
2d 11h$191–453
Chicago to Mesa by train, bus, and tram
Questions & Answers
The cheapest way to get from Chicago to Mesa is to train and bus via Flagstaff which costs $190 - $420 and takes 35h 59m.
The fastest way to get from Chicago to Mesa is to fly which takes 6h 22m and costs $170 - $900.
No, there is no direct bus from Chicago station to Mesa. However, there are services departing from Chicago Bus Station and arriving at University Dr & Mesa Dr via St Louis Bus Station, Phoenix Bus Station, Phoenix Sky Harbor Airport/44th Street Sky Train Station and University Dr & Rural Rd. The journey, including transfers, takes approximately 40h 33m.
The distance between Chicago and Mesa is 1475 miles. The road distance is 1698.7 miles.
The best way to get from Chicago to Mesa without a car is to train and bus via Flagstaff which takes 35h 59m and costs $190 - $420.
It takes approximately 6h 37m to get from Chicago to Mesa, including transfers.
Chicago to Mesa bus services, operated by Flixbus USA, depart from Chicago Bus Station.
The best way to get from Chicago to Mesa is to fly which takes 6h 37m and costs $270 - $700. Alternatively, you can bus, which costs $150 - $600 and takes 40h 33m.
Chicago to Mesa bus services, operated by Flixbus USA, arrive at St Louis Bus Station.
Mesa is 1h behind Chicago. It is currently 4:29 AM in Chicago and 3:29 AM in Mesa.
What companies run services between Chicago, IL, USA and Mesa, AZ, USA?
American Airlines, Frontier Airlines, and two other airlines fly from Chicago O'Hare International Airport (ORD) to Phoenix (PHX) hourly. Alternatively, you can take a bus from Chicago Bus Station to University Dr & Mesa Dr via St Louis Bus Station, Phoenix Bus Station, Phoenix Sky Harbor Airport/44th Street Sky Train Station, Tempe, and University Dr & Rural Rd in around 40h 33m.
- Website
- southwest.com
Flights from Chicago O'Hare International Airport to Phoenix
- Ave. Duration
- 4h 5m
- When
- Every day
- Estimated price
- $120–600
Flights from Chicago Midway International Airport to Phoenix
- Ave. Duration
- 3h 59m
- When
- Every day
- Estimated price
- $170–850
Flights from Chicago Midway International Airport to Phoenix via Kansas City
- Ave. Duration
- 5h 27m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $170–850
Flights from Chicago Midway International Airport to Phoenix via Des Moines
- Ave. Duration
- 5h 25m
- When
- Monday, Thursday, and Friday
- Estimated price
- $170–850
Flights from Chicago Midway International Airport to Phoenix via Omaha
- Ave. Duration
- 5h 40m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $170–850
Flights from Chicago Midway International Airport to Phoenix via Wichita Dwight D. Eisenhower
- Ave. Duration
- 5h 55m
- When
- Monday, Thursday, and Friday
- Estimated price
- $170–850
Flights from General Mitchell International Airport to Phoenix
- Ave. Duration
- 3h 56m
- When
- Every day
- Estimated price
- $220–1,100
Flights from General Mitchell International Airport to Phoenix via Denver
- Ave. Duration
- 5h 50m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $220–1,100
Flights from General Mitchell International Airport to Phoenix via Kansas City
- Ave. Duration
- 5h 50m
- When
- Monday, Thursday, and Friday
- Estimated price
- $220–1,100
Flights from General Mitchell International Airport to Phoenix via Chicago Midway International Airport
- Ave. Duration
- 6h
- When
- Thursday and Friday
- Estimated price
- $230–1,100
Flights from General Mitchell International Airport to Phoenix via Las Vegas
- Ave. Duration
- 6h 5m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $260–1,200
- Website
- aa.com
Flights from Chicago O'Hare International Airport to Phoenix
- Ave. Duration
- 4h
- When
- Every day
- Estimated price
- $120–600
Flights from General Mitchell International Airport to Phoenix
- Ave. Duration
- 4h
- When
- Every day
- Estimated price
- $220–1,100
Flights from General Mitchell International Airport to Phoenix via Chicago O'Hare International Airport
- Ave. Duration
- 6h 9m
- When
- Thursday
- Estimated price
- $230–1,100
- Website
- united.com
Flights from Chicago O'Hare International Airport to Phoenix
- Ave. Duration
- 4h 7m
- When
- Every day
- Estimated price
- $120–600
Flights from General Mitchell International Airport to Phoenix via Denver
- Ave. Duration
- 6h 2m
- When
- Every day
- Estimated price
- $220–1,100
- Website
- flyfrontier.com
Flights from Chicago O'Hare International Airport to Phoenix
- Ave. Duration
- 4h 9m
- When
- Every day
- Estimated price
- $120–600
Flights from Chicago Midway International Airport to Phoenix
- Ave. Duration
- 4h 12m
- When
- Thursday, Friday, and Sunday
- Estimated price
- $170–850
Flights from General Mitchell International Airport to Phoenix via Denver
- Ave. Duration
- 5h 54m
- When
- Friday
- Estimated price
- $220–1,100
- Website
- delta.com
Flights from General Mitchell International Airport to Phoenix via Minneapolis
- Ave. Duration
- 6h 3m
- When
- Every day
- Estimated price
- $230–1,100
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Chicago Union Station to Flagstaff
- Ave. Duration
- 31h 44m
- Frequency
- Twice daily
- Estimated price
- $160–370
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to Milwaukee
- Ave. Duration
- 1h 29m
- Frequency
- Every 4 hours
- Estimated price
- $22–40
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to Tucson Amtrak Station
- Ave. Duration
- 2d 8h
- Frequency
- 3 times a week
- Estimated price
- $160–420
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Flagstaff Train Station to Phoenix Sky Harbor Airport/44th Street Sky Train Station
- Ave. Duration
- 2h 25m
- Frequency
- Once daily
- Estimated price
- $30–50
- Schedules at
- flixbus.com
Bus from Chicago Bus Station to St Louis Bus Station
- Ave. Duration
- 6h 10m
- Frequency
- 3 times a day
- Estimated price
- $35–65
- Schedules at
- flixbus.com
Bus from Tucson Downtown to Tempe
- Ave. Duration
- 1h 50m
- Frequency
- 5 times a day
- Estimated price
- $26–40
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from St Louis Bus Station to Phoenix Bus Station
- Ave. Duration
- 30h
- Frequency
- Twice daily
- Estimated price
- $110–370
- Website
- https://www.greyhound.com/
Want to know more about travelling around United States
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More Questions & Answers
Yes, the driving distance between Chicago to Mesa is 1699 miles. It takes approximately 29h 41m to drive from Chicago to Mesa.
There are 2667+ hotels available in Mesa.









