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How to get fromChicago to Mesaby plane, train, bus, bus (Flixbus, Greyhound) or car

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There are 7 ways to get from Chicago to Mesa by plane, train, bus, bus (Flixbus, Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Chicago O'Hare International Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Phoenix (PHX)plane plane ORD - PHX
    6h 37m
    $274–657
  2. Bus

    cheapest
    1. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus N2521 / ...
    2. Take the bus from St Louis Bus Station to Phoenix Bus Stationbus bus Greyhound US1210
    40h 33m
    $156–596
  3. Train, bus via Flagstaff

    1. Take the train from Chicago Union Station to Flagstafftrain train Southwest Chief
    2. Take the bus from Flagstaff Train Station to Phoenix Sky Harbor Airport/44th Street Sky Train Stationbus bus FlixBus 2047
    35h 59m
    $198–420
  4. Drive 1,688.8 mi

    1. Drive from Chicago to Mesacar car 1,688.8 mi
    29h 41m
    $309–446
  5. Fly from Chicago Midway International Airport

    1. Fly from Chicago Midway International Airport (MDW) to Phoenix (PHX)plane plane MDW - PHX
    6h 22m
    $174–857
  6. Train to General Mitchell International Airport, fly

    1. Take the train from Chicago Union Station to Milwaukeetrain train
    2. Fly from General Mitchell International Airport (MKE) to Phoenix (PHX)plane plane MKE - PHX
    7h 49m
    $246–1,218
  7. Train, bus

    1. Take the train from Chicago Union Station to Tucson Amtrak Stationtrain train Texas Eagle
    2. Take the bus from Tucson Downtown to Tempebus bus FlixBus 2047 / ...
    2d 11h
    $191–453

Chicago to Mesa by train, bus, and tram

Calendar8Weekly Services
Duration35h 59mAverage Duration
Ticket$198Cheapest Price
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Questions & Answers

What companies run services between Chicago, IL, USA and Mesa, AZ, USA?

American Airlines, Frontier Airlines, and two other airlines fly from Chicago O'Hare International Airport (ORD) to Phoenix (PHX) hourly. Alternatively, you can take a bus from Chicago Bus Station to University Dr & Mesa Dr via St Louis Bus Station, Phoenix Bus Station, Phoenix Sky Harbor Airport/44th Street Sky Train Station, Tempe, and University Dr & Rural Rd in around 40h 33m.

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