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How to get fromChicago to Mesaby plane, train, bus, bus (Greyhound, Flixbus), or car

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There are 6 ways to get from Chicago to Mesa by plane, train, bus, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Chicago Midway International Airport

    best
    1. Fly from Chicago Midway International Airport (MDW) to Phoenix (PHX)plane plane MDW - PHX
    6h 4m
    $174–857

  2. Train, bus

    1. Take the train from Chicago Union Station to Flagstafftrain train Southwest Chief
    2. Take the bus from Flagstaff Train Station to Tempebus bus FlixBus 2047
    36h 5m
    $502–1,069

  3. Bus

    1. Take the bus from Chicago Bus Station to Denver Union Stationbus bus
    2. Take the bus from Denver Union Station to Las Vegas Bus Terminalbus bus
    3. Take the bus from Las Vegas Strip to Tempebus bus
    47h 33m
    $352–662

  4. Drive 1,688.8 mi

    1. Drive from Chicago to Mesacar car 1,688.8 mi
    29h 41m
    $309–446

  5. Fly from Chicago O'Hare International Airport

    1. Fly from Chicago O'Hare International Airport (ORD) to Phoenix (PHX)plane plane ORD - PHX
    6h 27m
    $254–657

  6. Train to General Mitchell International Airport, fly

    1. Take the train from Chicago Union Station to Milwaukeetrain train
    2. Fly from General Mitchell International Airport (MKE) to Phoenix (PHX)plane plane MKE - PHX
    7h 41m
    $238–1,068

Chicago to Mesa by train, bus, and tram

Calendar4Weekly Services
Duration36h 5mAverage Duration
Ticket$502Cheapest Price
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Questions & Answers

What companies run services between Chicago, IL, USA and Mesa, AZ, USA?

Southwest Airlines flies from Chicago Midway International Airport (MDW) to Phoenix (PHX) every 2 hours. Alternatively, you can take a bus from Chicago Bus Station to University Dr & Mesa Dr via Denver Union Station, Las Vegas Bus Terminal, Las Vegas Strip, Tempe, and University Dr & Rural Rd in around 47h 33m.

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