There are 8 ways to get from Chicago to Mayo Clinic by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Chicago O'Hare to Rochester  •  3 h 59 min

  1. Fly from Chicago O'Hare (ORD) to Rochester (RST) ORD - RST

$159 - $716

Cheapest option

Bus  •  9 h 8 min

  1. Take the bus from Chicago to Madison - Langdon & N Park
  2. Take the bus from Madison to Rochester, MN 966

$63 - $93

6 alternative options

Fly Chicago Midway to Minneapolis, bus  •  5 h 17 min

  1. Fly from Chicago Midway (MDW) to Minneapolis (MSP) MDW - MSP
  2. Take the bus from Minneapolis-St Paul Airport, MN to Rochester, MN

$84 - $309

Fly Chicago O'Hare to Minneapolis, bus  •  5 h 33 min

  1. Fly from Chicago O'Hare (ORD) to Minneapolis (MSP) ORD - MSP
  2. Take the bus from Minneapolis-St Paul Airport, MN to Rochester, MN

$64 - $240

Fly Chicago O'Hare to La Crosse, bus  •  6 h 10 min

  1. Fly from Chicago O'Hare (ORD) to La Crosse (LSE) ORD - LSE
  2. Take the bus from La Crosse, WI to Rochester, MN

$196 - $699

Train, bus  •  7 h 52 min

  1. Take the train from Chicago Union Station to Winona Amtrak Empire Builder
  2. Take the bus from Winona, MN to Rochester, MN

$89 - $172

Bus via Milwaukee  •  9 h 38 min

  1. Take the bus from Chicago, Il to Milwaukee, Wi 4712 / ...
  2. Take the bus from Milwaukee to Rochester, MN 966

$71 - $115

Drive  •  5 h 50 min

  1. Drive from Chicago to Mayo Clinic 350.3 miles

$30 - $50

Questions & Answers

No, there is no direct bus from Chicago to Mayo Clinic. However, there are services departing from Chicago and arriving at Rochester, MN via Madison. The journey, including transfers, takes approximately 9 h 8 min.

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The distance between Chicago and Mayo Clinic is 288 miles. The road distance is 350.3 miles.

Get driving directions

The best way to get from Chicago to Mayo Clinic without a car is to train and bus which takes 7 h 52 min and costs .

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It takes approximately 3 h 59 min to get from Chicago to Mayo Clinic, including transfers.

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Chicago to Mayo Clinic bus services, operated by Megabus, depart from Chicago station.

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The best way to get from Chicago to Mayo Clinic is to fly which takes 3 h 59 min and costs . Alternatively, you can bus, which costs and takes 9 h 8 min.

Mode details

The quickest flight from Chicago O'Hare Airport to Rochester Airport is the direct flight which takes 1 h 7 min.

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Chicago to Mayo Clinic bus services, operated by Jefferson Lines, arrive at Rochester, MN station.

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Yes, the driving distance between Chicago to Mayo Clinic is 350 miles. It takes approximately 5 h 50 min to drive from Chicago to Mayo Clinic.

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Delta, United Airlines and American Airlines offer flights from Chicago O'Hare Airport to Rochester Airport.

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Map of how to get from Chicago to Mayo Clinic.
Launch map view
  • Distance: 287.8 miles
  • Duration: 3 h 59 min

What companies run services between Chicago, IL, USA and Mayo Clinic, MN, USA?

American Airlines, United Airlines and Delta fly from Chicago to Mayo Clinic every 4 hours. Alternatively, you can take a bus from Chicago to Mayo Clinic via Madison - Langdon & N Park, Madison, and Rochester, MN in around 9 h 8 min.

Airlines
Southwest Airlines
Website
southwest.com
Flights from Chicago Midway to Minneapolis
Ave. Duration
1 h 25 min
When
Every day
Estimated price
$85 - $390
Flights from Chicago Midway to Minneapolis via Kansas City
Ave. Duration
3 h 35 min
When
Sunday
Estimated price
$85 - $390
Flights from Chicago Midway to Minneapolis via St. Louis
Ave. Duration
3 h 35 min
When
Monday to Friday
Estimated price
$85 - $390
American Airlines
Website
aa.com
Flights from Chicago O'Hare to Rochester
Ave. Duration
1 h 11 min
When
Every day
Estimated price
$260 - $750
Flights from Chicago O'Hare to Minneapolis
Ave. Duration
1 h 27 min
When
Every day
Estimated price
$70 - $350
Flights from Chicago O'Hare to La Crosse
Ave. Duration
1 h 7 min
When
Every day
Estimated price
$260 - $850
United Airlines
Website
united.com
Flights from Chicago O'Hare to Rochester
Ave. Duration
1 h 19 min
When
Every day
Estimated price
$150 - $750
Flights from Chicago O'Hare to Minneapolis
Ave. Duration
1 h 35 min
When
Every day
Estimated price
$75 - $400
Delta
Website
delta.com
Flights from Chicago O'Hare to Rochester via Minneapolis
Ave. Duration
3 h 7 min
When
Monday to Friday
Estimated price
$320 - $750
Flights from Chicago Midway to Minneapolis
Ave. Duration
1 h 33 min
When
Every day
Estimated price
$80 - $390
Flights from Chicago O'Hare to Minneapolis
Ave. Duration
1 h 34 min
When
Every day
Estimated price
$80 - $420
Air Choice One
Website
airchoiceone.com
Flights from Chicago O'Hare to Minneapolis via Mason City
Ave. Duration
3 h 45 min
When
Saturday and Sunday
Estimated price
$140 - $420
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Chicago Union Station to Winona Amtrak
Ave. Duration
5 h 26 min
Frequency
3 times a day
Estimated price
$50 - $140
Website
amtrak.com
Coach Seat
$50 - $80
Flexi Coach Seat
$95 - $140
Business Coach Seat
$95 - $140
Room
$240 - $340
Bus operators
Jefferson Lines
Phone
800-451-5333
Email
info@jeffersonlines.com
Website
jeffersonlines.com
Bus from Minneapolis-St Paul Airport, MN to Rochester, MN
Ave. Duration
1 h 20 min
Frequency
Every 3 hours
Estimated price
$22 - $35
Book at
jeffersonlines.com
Bus from Madison to Rochester, MN
Ave. Duration
4 h 45 min
Frequency
Every 3 hours
Estimated price
$45 - $65
Book at
jeffersonlines.com
Bus from Milwaukee to Rochester, MN
Ave. Duration
6 h 10 min
Frequency
Every 3 hours
Estimated price
$55 - $80
Book at
jeffersonlines.com
Go Carefree Shuttle
Website
gocarefreeshuttle.com
Bus from La Crosse, WI to Rochester, MN
Ave. Duration
1 h 50 min
Frequency
Every 4 hours
Estimated price
$44
Schedules at
gocarefreeshuttle.com
Bus from Winona, MN to Rochester, MN
Ave. Duration
1 h 20 min
Frequency
Every 4 hours
Estimated price
$35
Schedules at
gocarefreeshuttle.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Chicago, Il to Milwaukee, Wi
Ave. Duration
2 h 20 min
Frequency
Every 20 minutes
Estimated price
$15 - $35
Website
greyhound.com
Economy
$15 - $23
Flexible
$28 - $35

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More Questions & Answers

There are 56+ hotels available in Mayo Clinic. Prices start at $67 USD per night.

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The best way to get from Chicago to Chicago O'Hare Airport is to subway which takes 42 min and costs .

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