There are 8 ways to get from Chicago to Mayo Clinic by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Chicago O'Hare to Rochester  •  4 h 7 min

  1. Fly from Chicago O'Hare (ORD) to Rochester (RST) ORD - RST

$159 - $716

Cheapest option

Amtrak Thruway, bus  •  10 h 23 min

  1. Take the Amtrak Thruway from Chicago, IL to Madison, WI - Univ. of Wisconsin 8960
  2. Take the bus from Madison to Rochester, MN 966

$45 - $65

6 alternative options

Fly Chicago Midway to Minneapolis, bus  •  5 h 17 min

  1. Fly from Chicago Midway (MDW) to Minneapolis (MSP) MDW - MSP
  2. Take the bus from Minneapolis-St Paul Airport, MN to Rochester, MN

$84 - $309

Fly Chicago O'Hare to Minneapolis, bus  •  5 h 34 min

  1. Fly from Chicago O'Hare (ORD) to Minneapolis (MSP) ORD - MSP
  2. Take the bus from Minneapolis-St Paul Airport, MN to Rochester, MN

$64 - $240

Fly Chicago O'Hare to La Crosse, bus  •  6 h 11 min

  1. Fly from Chicago O'Hare (ORD) to La Crosse (LSE) ORD - LSE
  2. Take the bus from La Crosse, WI to Rochester, MN

$196 - $699

Train, bus  •  7 h 52 min

  1. Take the train from Chicago Union Station Amtrak to Winona Amtrak Empire Builder
  2. Take the bus from Winona, MN to Rochester, MN

$89 - $172

Bus  •  9 h 8 min

  1. Take the bus from Chicago, Il to Milwaukee, Wi 4716 / ...
  2. Take the bus from Milwaukee to Rochester, MN 966

$70 - $114

Drive  •  5 h 50 min

  1. Drive from Chicago to Mayo Clinic 350.3 miles

$30 - $50

Questions & Answers

The cheapest way to get from Chicago to Mayo Clinic is to drive which costs $30 - $50 and takes 5 h 50 min.

More details

The quickest way to get from Chicago to Mayo Clinic is to fly which costs $150 - $750 and takes 4 h 7 min.

More details

The distance between Chicago and Mayo Clinic is 288 miles. The road distance is 350.3 miles.

Get driving directions

It takes approximately 4 h 7 min to get from Chicago to Mayo Clinic, including transfers.

More details

No, there is no direct bus from Chicago to Mayo Clinic. However, there are services departing from Chicago, Il and arriving at Rochester, MN via Milwaukee. The journey, including transfers, takes approximately 9 h 8 min.

More details

What companies run services between Chicago, IL, USA and Mayo Clinic, MN, USA?

American Airlines and United Airlines fly from Chicago to Mayo Clinic every 4 hours. Alternatively, you can take a bus from Chicago to Mayo Clinic via Milwaukee, Wi, Milwaukee, and Rochester, MN in around 9 h 8 min.

Airlines
Southwest Airlines
Website
southwest.com
Flights from Chicago Midway to Minneapolis
Ave. Duration
1 h 24 min
When
Every day
Estimated price
$85 - $390
American Airlines
Website
aa.com
Flights from Chicago O'Hare to Rochester
Ave. Duration
1 h 15 min
When
Every day
Estimated price
$260 - $750
Flights from Chicago O'Hare to Minneapolis
Ave. Duration
1 h 27 min
When
Every day
Estimated price
$70 - $350
Flights from Chicago O'Hare to La Crosse
Ave. Duration
1 h 8 min
When
Every day
Estimated price
$260 - $850
Delta
Website
delta.com
Flights from Chicago Midway to Minneapolis
Ave. Duration
1 h 34 min
When
Every day
Estimated price
$80 - $390
Flights from Chicago O'Hare to Minneapolis
Ave. Duration
1 h 34 min
When
Every day
Estimated price
$80 - $420
United Airlines
Website
united.com
Flights from Chicago O'Hare to Rochester
Ave. Duration
1 h 21 min
When
Every day
Estimated price
$150 - $750
Flights from Chicago O'Hare to Minneapolis
Ave. Duration
1 h 31 min
When
Every day
Estimated price
$75 - $400
Air Choice One
Website
airchoiceone.com
Flights from Chicago O'Hare to Minneapolis via Mason City
Ave. Duration
3 h 45 min
When
Saturday and Sunday
Estimated price
$140 - $420
Train operators
Amtrak
Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Chicago Union Station Amtrak to Winona Amtrak
Ave. Duration
5 h 26 min
Frequency
3 times a day
Estimated price
$50 - $140
Website
amtrak.com
Coach Seat
$50 - $80
Flexi Coach Seat
$95 - $140
Business Coach Seat
$95 - $140
Room
$240 - $340
Bus operators
Jefferson Lines
Phone
800-451-5333
Email
info@jeffersonlines.com
Website
jeffersonlines.com
Bus from Minneapolis-St Paul Airport, MN to Rochester, MN
Ave. Duration
1 h 20 min
Frequency
Every 3 hours
Estimated price
$22 - $35
Schedules at
jeffersonlines.com
Bus from Milwaukee to Rochester, MN
Ave. Duration
6 h 10 min
Frequency
Every 3 hours
Estimated price
$55 - $80
Schedules at
jeffersonlines.com
Bus from Madison to Rochester, MN
Ave. Duration
4 h 45 min
Frequency
Every 3 hours
Estimated price
$45 - $65
Schedules at
jeffersonlines.com
Go Carefree Shuttle
Website
gocarefreeshuttle.com
Bus from La Crosse, WI to Rochester, MN
Ave. Duration
1 h 50 min
Frequency
Every 4 hours
Estimated price
$44
Schedules at
gocarefreeshuttle.com
Bus from Winona, MN to Rochester, MN
Ave. Duration
1 h 20 min
Frequency
Every 4 hours
Estimated price
$35
Schedules at
gocarefreeshuttle.com
Greyhound USA
Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Chicago, Il to Milwaukee, Wi
Ave. Duration
1 h 50 min
Frequency
Every 30 minutes
Estimated price
$15 - $35
Website
greyhound.com
Economy
$15 - $23
Flexible
$27 - $35

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