There are 4 ways to get from Chicago to Kirksville by train, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Train  •  5 h 9 min

  1. Take the train from Chicago Union Station Amtrak to La Plata Amtrak Southwest Chief

$83 - $174

3 alternative options

Drive  •  6 h 49 min

  1. Drive from Chicago to Kirksville 383.1 miles

$35 - $55

Fly Chicago Midway to Kirksville  •  5 h 2 min

  1. Fly from Chicago Midway (MDW) to Kirksville (IRK) MDW - IRK

$172 - $729

Fly Chicago O'Hare to Burlington, train  •  9 h 1 min

  1. Fly from Chicago O'Hare (ORD) to Burlington (BRL) ORD - BRL
  2. Take the train from Burlington Amtrak to Galesburg Amtrak
  3. Take the train from Galesburg Amtrak to La Plata Amtrak

$148 - $247

Questions & Answers

The cheapest way to get from Chicago to Kirksville is to drive which costs $35 - $55 and takes 6 h 49 min.

More details

The quickest way to get from Chicago to Kirksville is to fly which costs $170 - $750 and takes 5 h 2 min.

More details

The distance between Chicago and Kirksville is 285 miles. The road distance is 383.1 miles.

Get driving directions

It takes approximately 5 h 9 min to get from Chicago to Kirksville, including transfers.

More details

What companies run services between Chicago, IL, USA and Kirksville, MO, USA?

Amtrak operates a train from Chicago to Kirksville once daily. Tickets cost $50 - $140 and the journey takes 4 h 52 min. Alternatively, Southwest Airlines, Cape Air and Delta fly from Chicago to Kirksville every 4 hours.

Airlines
Cape Air
Website
capeair.com
Flights from Chicago Midway to Kirksville via St. Louis
Ave. Duration
4 h 10 min
When
Saturday and Sunday
Estimated price
$150 - $700
Flights from Chicago Midway to Kirksville via Kansas City, St. Louis
Ave. Duration
6 h 30 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $800
Flights from Chicago Midway to Kirksville via Detroit, St. Louis
Ave. Duration
6 h 30 min
When
Monday to Friday
Estimated price
$160 - $800
Flights from Chicago Midway to Kirksville via Columbus, St. Louis
Ave. Duration
6 h 40 min
When
Sunday
Estimated price
$190 - $800
Flights from Chicago Midway to Kirksville via Minneapolis, St. Louis
Ave. Duration
6 h 57 min
When
Saturday and Sunday
Estimated price
$190 - $850
Flights from Chicago Midway to Kirksville via Dallas, St. Louis
Ave. Duration
6 h 55 min
When
Sunday
Estimated price
$250 - $950
Flights from Chicago Midway to Kirksville via Atlanta, St. Louis
Ave. Duration
7 h 20 min
When
Saturday
Estimated price
$190 - $900
Flights from Chicago Midway to Kirksville via Cleveland, St. Louis
Ave. Duration
7 h 35 min
When
Sunday
Estimated price
$200 - $850
Air Choice One
Website
airchoiceone.com
Flights from Chicago O'Hare to Burlington
Ave. Duration
1 h 40 min
When
Every day
Estimated price
$50 - $120
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Chicago Union Station Amtrak to La Plata Amtrak
Ave. Duration
4 h 52 min
Frequency
Once daily
Estimated price
$50 - $140
Website
amtrak.com
Coach Seat
$50 - $80
Flexi Coach Seat
$90 - $140
Business Coach Seat
$95 - $140
Room
$240 - $330
Train from Burlington Amtrak to Galesburg Amtrak
Ave. Duration
1 h 5 min
Frequency
Once daily
Estimated price
$23 - $45
Website
amtrak.com
Coach Seat
$23 - $35
Flexi Coach Seat
$40 - $60
Business Coach Seat
$30 - $45
Room
$130 - $190
Train from Galesburg Amtrak to La Plata Amtrak
Ave. Duration
2 h 11 min
Frequency
Once daily
Estimated price
$30 - $80
Website
amtrak.com
Coach Seat
$30 - $50
Flexi Coach Seat
$60 - $85
Business Coach Seat
$55 - $80
Room
$170 - $240

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