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How to get fromChicago to Iowaby plane, bus (Greyhound), car, bus, or train

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There are 8 ways to get from Chicago to Iowa by plane, bus (Greyhound), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Des Moines

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Des Moines (DSM)plane plane ORD - DSM
    3h 25m
    $94–576

  2. Fly Chicago O'Hare International Airport to Quad City International Airport, line 10 bus

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Quad City International Airport (MLI)plane plane ORD - MLI
    2. Take the bus from Centre Station to Districtbus bus
    4h 24m
    $34–267

  3. Bus (Greyhound)

    1. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    6h 35m
    $58–103

  4. Drive 330 mi

    1. Drive from Chicago to Des Moinescar car 330 mi
    5h 32m
    $61–87

  5. Fly Chicago Midway International Airport to Omaha

    1. Fly from Chicago Midway International Airport (MDW) to Omaha (OMA)plane plane MDW - OMA
    3h 15m
    $138–735

  6. Fly Chicago Midway International Airport to Des Moines

    1. Fly from Chicago Midway International Airport (MDW) to Des Moines (DSM)plane plane MDW - DSM
    3h 5m
    $120–776

  7. Fly Chicago O'Hare International Airport to The Eastern Iowa Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to The Eastern Iowa Airport (CID)plane plane ORD - CID
    2. Take the bus from GTC Bay 9 to Court St Transportation Centerbus bus
    6h 1m

  8. Train, bus

    1. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train Southwest Chief / ...
    2. Take the bus from Galesburg to Des Moinesbus bus Greyhound US0157S
    8h 36m
    $90–175

Chicago O'Hare International Airport (ORD) to Des Moines (DSM) flights

Calendar76Weekly Planes
Duration1h 44mAverage Duration
Ticket$79Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Iowa.ExpandLaunch map view
  • Distance: 321.9 mi
  • Duration: 3h 25m

What companies run services between Chicago, IL, USA and Iowa, USA?

American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Des Moines (DSM) every 2 hours. Alternatively, Greyhound USA operates a bus from Chicago Bus Station to Des Moines 3 times a day. Tickets cost $50–95 and the journey takes 6h 30m.

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