There are 7 ways to get from Chicago to Greenville by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  3 h 46 min

  1. Fly from Chicago O'Hare (ORD) to Greenville/Spartanburg (GSP) ORD - GSP

$172 - $600

Cheapest option

Bus Greyhound USA #2  •  26 h 56 min

  1. Take the bus from Chicago Amtrak, Il to Atlanta, Ga 1151 / ...
  2. Take the bus from Atlanta, GA to Greenville

$108 - $246

5 alternative options

Bus Megabus  •  18 h 29 min

  1. Take the bus from Chicago to Marta Civic Center Station - Nb
  2. Take the bus from Doraville, GA to Greenville, SC

$132 - $157

Bus Greyhound USA  •  20 h 14 min

  1. Take the bus from Chicago, Il to Atlanta, Ga 1151
  2. Take the bus from Atlanta ,GA to Greenville, SC

$143 - $249

Train  •  28 h 49 min

  1. Take the train from Chicago Union Station Amtrak to Washington Union Station Amtrak Capitol Limited
  2. Take the train from Washington Union Station Amtrak to Greenville Amtrak Crescent

$179 - $505

Train via Charlottesville Amtrak  •  29 h 27 min

  1. Take the train from Chicago Union Station Amtrak to Charlottesville Amtrak Cardinal
  2. Take the train from Charlottesville Amtrak to Greenville Amtrak Crescent

$171 - $473

Drive  •  12 h

  1. Drive from Chicago to Greenville 710.3 miles

$65 - $100

Questions & Answers

The cheapest way to get from Chicago to Greenville is to drive which costs $65 - $100 and takes 12 h.

More details

The quickest way to get from Chicago to Greenville is to fly which costs $170 - $600 and takes 3 h 46 min.

More details

The distance between Chicago and Greenville is 565 miles. The road distance is 710.3 miles.

Get driving directions

It takes approximately 3 h 46 min to get from Chicago to Greenville, including transfers.

More details

No, there is no direct train from Chicago station to Greenville. However, there are services departing from Chicago Union Station Amtrak and arriving at Greenville Amtrak via Washington Union Station Amtrak. The journey, including transfers, takes approximately 28 h 49 min.

More details

What companies run services between Chicago, IL, USA and Greenville, SC, USA?

American Airlines, United Airlines and Delta fly from Chicago to Greenville hourly. Alternatively, you can take a bus from Chicago to Greenville via Marta Civic Center Station - Nb, Civic Center Station, Doraville Station, Doraville, GA, and Greenville, SC in around 18 h 29 min.

Airlines
American Airlines
Website
aa.com
Flights from Chicago O'Hare to Greenville/Spartanburg
Ave. Duration
1 h 48 min
When
Every day
Estimated price
$280 - $800
Flights from Chicago O'Hare to Greenville/Spartanburg via Charlotte
Ave. Duration
3 h 47 min
When
Every day
Estimated price
$280 - $800
United Airlines
Website
united.com
Flights from Chicago O'Hare to Greenville/Spartanburg
Ave. Duration
1 h 55 min
When
Every day
Estimated price
$280 - $1,100
Delta
Website
delta.com
Flights from Chicago O'Hare to Greenville/Spartanburg via Atlanta
Ave. Duration
3 h 56 min
When
Every day
Estimated price
$260 - $1,300
Flights from Chicago O'Hare to Greenville/Spartanburg via Detroit
Ave. Duration
3 h 57 min
When
Monday to Saturday
Estimated price
$260 - $1,300
Train operators
Amtrak
Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Chicago Union Station Amtrak to Washington Union Station Amtrak
Ave. Duration
17 h 25 min
Frequency
Once daily
Estimated price
$100 - $310
Website
amtrak.com
Coach Seat
$100 - $160
Flexi Coach Seat
$190 - $280
Business Coach Seat
$220 - $310
Room
$440 - $600
Train from Washington Union Station Amtrak to Greenville Amtrak
Ave. Duration
10 h 24 min
Frequency
Once daily
Estimated price
$70 - $200
Website
amtrak.com
Coach Seat
$70 - $110
Flexi Coach Seat
$130 - $190
Business Coach Seat
$140 - $200
Room
$310 - $440
Train from Chicago Union Station Amtrak to Charlottesville Amtrak
Ave. Duration
20 h 25 min
Frequency
4 times a week
Estimated price
$110 - $320
Website
amtrak.com
Coach Seat
$110 - $170
Flexi Coach Seat
$190 - $280
Business Coach Seat
$220 - $320
Room
$450 - $650
Train from Charlottesville Amtrak to Greenville Amtrak
Ave. Duration
8 h 2 min
Frequency
Once daily
Estimated price
$60 - $160
Website
amtrak.com
Coach Seat
$60 - $90
Flexi Coach Seat
$100 - $160
Business Coach Seat
$110 - $160
Room
$270 - $380
Bus operators
Megabus
Pandora Bus
Website
pandorabus.com
Bus from Doraville, GA to Greenville, SC
Ave. Duration
2 h 15 min
Frequency
Every 4 hours
Estimated price
$60
Schedules at
pandorabus.com
Book at
search.gotobus.com
Bus from Atlanta ,GA to Greenville, SC
Ave. Duration
3 h
Frequency
Every 4 hours
Estimated price
$60
Schedules at
pandorabus.com
Book at
search.gotobus.com
Greyhound USA
Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Chicago, Il to Atlanta, Ga
Ave. Duration
15 h 45 min
Frequency
Every 3 hours
Estimated price
$70 - $180
Website
greyhound.com
Economy
$70 - $120
Flexible
$130 - $180
Bus from Chicago Amtrak, Il to Atlanta, Ga
Ave. Duration
16 h 30 min
Frequency
Hourly
Estimated price
$70 - $180
Website
greyhound.com
Economy
$70 - $120
Flexible
$130 - $180

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.