There are 4 ways to get from Chicago to Greenville by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  3 h 45 min

  1. Fly from Chicago O'Hare (ORD) to Greenville/Spartanburg (GSP) ORD - GSP

$172 - $600

Cheapest option

Bus  •  20 h 14 min

  1. Take the bus from Chicago, Il to Atlanta, Ga 1151 / ...
  2. Take the bus from Atlanta ,GA to Greenville, SC

$143 - $249

2 alternative options

Train, bus  •  29 h 36 min

  1. Take the train from Chicago Union Station to Charlottesville Amtrak
  2. Take the train from Charlottesville Amtrak to Charlotte Amtrak
  3. Take the bus from Charlotte, NC to Greenville, SC

$340 - $634

Drive  •  12 h

  1. Drive from Chicago to Greenville 710.3 miles

$65 - $100

Questions & Answers

The distance between Chicago and Greenville is 565 miles. The road distance is 710.3 miles.

Get driving directions

The best way to get from Chicago to Greenville without a car is to bus which takes 20 h 14 min and costs .

More details

It takes approximately 3 h 45 min to get from Chicago to Greenville, including transfers.

More details

The best way to get from Chicago to Greenville is to fly which takes 3 h 45 min and costs . Alternatively, you can bus, which costs and takes 20 h 14 min.

Mode details

The quickest flight from Chicago O'Hare Airport to Greenville/Spartanburg Airport is the direct flight which takes 1 h 46 min.

Search flights

Greenville is 1 h ahead of Chicago. It is currently 2:55 AM in Chicago and 3:55 AM in Greenville.

Yes, the driving distance between Chicago to Greenville is 710 miles. It takes approximately 12 h to drive from Chicago to Greenville.

Get driving directions

United Airlines, American Airlines and Delta offer flights from Chicago O'Hare Airport to Greenville/Spartanburg Airport.

Search flights

There are 83+ hotels available in Greenville. Prices start at $69 USD per night.

More details

The best way to get from Chicago to Chicago O'Hare Airport is to subway which takes 42 min and costs .

More details

Map of how to get from Chicago to Greenville.
Launch map view
  • Distance: 565 miles
  • Duration: 3 h 45 min

What companies run services between Chicago, IL, USA and Greenville, SC, USA?

American Airlines, United Airlines and Delta fly from Chicago to Greenville hourly. Alternatively, you can take a bus from Chicago to Greenville via Atlanta, Ga, Alabama St @ Forsyth St, University Ave Sw@Pryor Rd Sw, Atlanta ,GA, and Greenville, SC in around 20 h 14 min.

Airlines
American Airlines
Website
aa.com
Flights from Chicago O'Hare to Greenville/Spartanburg
Ave. Duration
1 h 48 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$280 - $800
Flights from Chicago O'Hare to Greenville/Spartanburg via Charlotte
Ave. Duration
3 h 47 min
When
Every day
Estimated price
$280 - $800
Delta
Website
delta.com
Flights from Chicago O'Hare to Greenville/Spartanburg via Atlanta
Ave. Duration
3 h 51 min
When
Every day
Estimated price
$260 - $1,300
Flights from Chicago O'Hare to Greenville/Spartanburg via Detroit
Ave. Duration
4 h
When
Saturday
Estimated price
$260 - $1,300
United Airlines
Website
united.com
Flights from Chicago O'Hare to Greenville/Spartanburg
Ave. Duration
1 h 55 min
When
Every day
Estimated price
$280 - $1,100
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Chicago Union Station to Charlottesville Amtrak
Ave. Duration
20 h 25 min
Frequency
4 times a week
Estimated price
$110 - $320
Website
amtrak.com
Coach Seat
$110 - $170
Flexi Coach Seat
$190 - $280
Business Coach Seat
$220 - $320
Room
$450 - $650
Train from Charlottesville Amtrak to Charlotte Amtrak
Ave. Duration
5 h 28 min
Frequency
Once daily
Estimated price
$45 - $130
Website
amtrak.com
Coach Seat
$45 - $75
Flexi Coach Seat
$85 - $130
Business Coach Seat
$85 - $130
Room
$220 - $320
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Chicago, Il to Atlanta, Ga
Ave. Duration
15 h 45 min
Frequency
Hourly
Estimated price
$70 - $180
Website
greyhound.com
Economy
$70 - $120
Flexible
$130 - $180
Pandora Bus
Website
pandorabus.com
Bus from Atlanta ,GA to Greenville, SC
Ave. Duration
3 h
Frequency
Every 4 hours
Estimated price
$60
Schedules at
pandorabus.com
Book at
search.gotobus.com
La Cubana
Phone
+1 305-541-1700
Website
lacubanabus.com
Bus from Charlotte, NC to Greenville, SC
Ave. Duration
1 h 30 min
Frequency
3 times a week
Estimated price
$159
Schedules at
lacubanabus.com

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.