Travel options for:
Chicago to Great Smoky Mountains
  • Fly to Knoxville, drive

    $158 - $435
    1. Chicago

      43 min - every 10 minutes

      $2 - $5

    2. Chicago O'Hare (ORD)

      1 h 35 min - non-stop

      $150 - $420

    3. Knoxville (TYS)

      1 h 58 min - 68.7 miles

      $6 - $10

  • Fly to Asheville, drive

    $150 - $337
    1. Chicago

      43 min - every 10 minutes

      $2 - $5

    2. Chicago O'Hare (ORD)

      1 h 49 min - non-stop

      $140 - $320

    3. Asheville (AVL)

      2 h 9 min - 84.6 miles

      $8 - $12

  • Fly to Greenville/Spartanburg, drive

    $155 - $575
    1. Chicago

      43 min - every 10 minutes

      $2 - $5

    2. Chicago O'Hare (ORD)

      1 h 45 min - non-stop

      $140 - $550

    3. Greenville/Spartanburg (GSP)

      3 h 13 min - 137 miles

      $13 - $20

  • Bus, Megabus, drive

    $75 - $102
    1. Chicago

      12 h 14 min - twice daily

      $55 - $70

    2. Chattanooga

      2 h - once daily

      $12 - $22

    3. Knoxville

      1 h 45 min - 65.6 miles

      $6 - $10

  • Train, bus, drive

    $84 - $184
    1. Chicago Union Station Amtrak

      5 h 16 min - once daily

      $27 - $50

    2. Carbondale Amtrak

      10 min - 2901 feet

    3. Carbondale, IL

      4 h 14 min - once daily

      $27 - $65

    4. Nashville, TN

      3 h 33 min - once daily

      $24 - $60

    5. Knoxville, TN

      1 h 45 min - 65.2 miles

      $6 - $10

  • Bus, drive

    $30 - $67
    1. Chicago, IL

      11 h - once daily

    2. Nashville, TN

      3 h 33 min - once daily

      $24 - $60

    3. Knoxville, TN

      1 h 45 min - 65.2 miles

      $6 - $10

  • Train, bus, drive via Cincinnati, OH

    $95 - $218
    1. Chicago Union Station Amtrak

      4 h 54 min - 4 times a week

      $40 - $100

    2. Indianapolis, IN

      3 h 14 min - once daily

      $18 - $35

    3. Cincinnati, OH

      5 h 31 min - once daily

      $30 - $75

    4. Knoxville, TN

      1 h 45 min - 65.2 miles

      $6 - $10

  • Drive

    $55 - $90
    1. Chicago

      10 h 37 min - 606.6 miles

      $55 - $90

  • Accommodation
  • Best Price Guarantee
  • Car Hire
  • Compare Best Rates
  • Things to do
  • View attractions

From Jackson-Blue subway to Chicago O'Hare airport, fly to Knoxville airport, then drive to Great Smoky Mountains. 5 h 16 min $222. From Jackson-Blue subway to Chicago O'Hare airport, fly to Asheville airport, then drive to Great Smoky Mountains. 5 h 41 min $204. From Jackson-Blue subway to Chicago O'Hare airport, fly to Greenville/Spartanburg airport, then drive to Great Smoky Mountains. 6 h 41 min $260. From Chicago bus to Chattanooga, Megabus to Knoxville, then drive to Great Smoky Mountains. 16 h 59 min $85. From Chicago Union Station Amtrak train to Carbondale Amtrak, walk to Carbondale, IL, bus to Nashville, TN, bus to Knoxville, TN, then drive to Great Smoky Mountains. 16 h 58 min $127. From Chicago, IL bus to Nashville, TN, bus to Knoxville, TN, then drive to Great Smoky Mountains. 17 h 18 min $49. From Chicago Union Station Amtrak train to Indianapolis, IN, bus to Cincinnati, OH, bus to Knoxville, TN, then drive to Great Smoky Mountains. 17 h 24 min $163. From Chicago drive to Great Smoky Mountains. 10 h 37 min $72.