There are 5 ways to get from Chicago to Great Smoky Mountains by plane, car or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Knoxville, drive  •  5 h 13 min

  1. Fly from Chicago O'Hare (ORD) to Knoxville (TYS) ORD - TYS
  2. Drive from Knoxville to Great Smoky Mountains

$158 - $435

Cheapest option

Bus, Megabus, drive  •  16 h 59 min

  1. Take the bus from Chicago to Chattanooga
  2. Take the Megabus from Chattanooga to Knoxville
  3. Drive from Knoxville to Great Smoky Mountains

$75 - $102

3 alternative options

Fly to Asheville, drive  •  5 h 45 min

  1. Fly from Chicago O'Hare (ORD) to Asheville (AVL) ORD - AVL
  2. Drive from Asheville to Great Smoky Mountains

$150 - $337

Fly to Greenville/Spartanburg, drive  •  6 h 42 min

  1. Fly from Chicago O'Hare (ORD) to Greenville/Spartanburg (GSP) ORD - GSP
  2. Drive from Greenville/Spartanburg to Great Smoky Mountains

$155 - $575

Drive  •  10 h 37 min

  1. Drive from Chicago to Great Smoky Mountains 606.6 miles

$55 - $90

Questions & Answers

The cheapest way to get from Chicago to Great Smoky Mountains is to drive which costs $55 - $90 and takes 10 h 37 min.

More details

The quickest way to get from Chicago to Great Smoky Mountains is to fly and drive which costs $150 - $440 and takes 5 h 13 min.

More details

The distance between Chicago and Great Smoky Mountains is 491 miles. The road distance is 606.6 miles.

Get driving directions

It takes approximately 5 h 13 min to get from Chicago to Great Smoky Mountains, including transfers.

More details

What companies run services between Chicago, IL, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Chicago to Great Smoky Mountains. However, you can take the subway to O'Hare, take the walk to Chicago O'Hare airport, fly to Knoxville, then take the drive to Great Smoky Mountains. Alternatively, you can take the subway to O'Hare, take the walk to Chicago O'Hare airport, fly to Asheville, then take the drive to Great Smoky Mountains.

Airlines
American Airlines
Website
aa.com
Flights from Chicago O'Hare to Knoxville
Ave. Duration
1 h 33 min
When
Every day
Estimated price
$330 - $750
Flights from Chicago O'Hare to Knoxville via Charlotte
Ave. Duration
3 h 52 min
When
Every day
Estimated price
$330 - $750
Flights from Chicago O'Hare to Asheville via Charlotte
Ave. Duration
4 h
When
Every day
Estimated price
$290 - $700
Flights from Chicago O'Hare to Greenville/Spartanburg
Ave. Duration
1 h 48 min
When
Every day
Estimated price
$280 - $800
Flights from Chicago O'Hare to Greenville/Spartanburg via Charlotte
Ave. Duration
3 h 47 min
When
Every day
Estimated price
$280 - $800
United Airlines
Website
united.com
Flights from Chicago O'Hare to Knoxville
Ave. Duration
1 h 43 min
When
Every day
Estimated price
$300 - $750
Flights from Chicago O'Hare to Asheville
Ave. Duration
1 h 53 min
When
Every day
Estimated price
$290 - $700
Flights from Chicago O'Hare to Greenville/Spartanburg
Ave. Duration
1 h 55 min
When
Every day
Estimated price
$280 - $1,100
Delta
Website
delta.com
Flights from Chicago O'Hare to Knoxville via Detroit
Ave. Duration
3 h 47 min
When
Every day
Estimated price
$340 - $850
Flights from Chicago O'Hare to Knoxville via Atlanta
Ave. Duration
3 h 50 min
When
Monday to Friday
Estimated price
$340 - $850
Flights from Chicago O'Hare to Asheville via Atlanta
Ave. Duration
4 h 7 min
When
Every day
Estimated price
$310 - $750
Flights from Chicago O'Hare to Greenville/Spartanburg via Atlanta
Ave. Duration
3 h 56 min
When
Every day
Estimated price
$260 - $1,300
Flights from Chicago O'Hare to Greenville/Spartanburg via Detroit
Ave. Duration
3 h 57 min
When
Monday to Saturday
Estimated price
$260 - $1,300
Bus operators
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Chicago to Chattanooga
Ave. Duration
12 h 14 min
Frequency
Twice daily
Estimated price
$55 - $70
Schedules at
us.megabus.com
Bus from Chattanooga to Knoxville
Ave. Duration
2 h
Frequency
Twice daily
Estimated price
$12 - $22
Schedules at
us.megabus.com

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