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How to get fromChicago to Duke Universityby plane, bus, bus (Greyhound, Flixbus), train, car, or subway

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There are 6 ways to get from Chicago to Duke University by plane, bus, bus (Greyhound, Flixbus), train, car, or subway

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Raleigh-Durham International Airport, bus, line 700 bus, line 6 bus

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Raleigh-Durham International Airport (RDU)plane plane ORD - RDU
    2. Take the bus from RDU Airport at Terminal 2 to Regional Transit Centerbus bus
    3. Take the bus from Regional Transit Center to Pettigrew St at Parking Deckbus bus
    4. Take the bus from Durham Station to Flowers Dr at Duke Gardensbus bus
    5h 56m
    $74–399

  2. Bus

    1. Take the bus from Chicago Bus Station to Washington Union Stationbus bus Greyhound US0164
    2. Take the bus from Washington Union Station to Durhambus bus FlixBus N2471 / ...
    23h 16m
    $140–293

  3. Train, bus

    1. Take the train from Chicago Union Station to Raleigh Union Stationtrain train Floridian
    2. Take the bus from Union Station - Bus Platform A to Chapel Dr at Duke University Rdbus bus Drx
    26h 14m
    $315–657

  4. Drive 750.9 mi

    1. Drive from Chicago to Duke Universitycar car 750.9 mi
    14h 2m
    $137–198

  5. Subway to Chicago Midway International Airport, fly to Raleigh-Durham International Airport, bus, line 700 bus, line 6 bus

    1. Take the subway from Adams/Wabash to Midwaysubway subway
    2. Fly from Chicago Midway International Airport (MDW) to Raleigh-Durham International Airport (RDU)plane plane MDW - RDU
    3. Take the bus from RDU Airport at Terminal 2 to Regional Transit Centerbus bus
    4. Take the bus from Regional Transit Center to Pettigrew St at Parking Deckbus bus
    5. Take the bus from Durham Station to Flowers Dr at Duke Gardensbus bus
    5h 34m
    $104–559

  6. Fly Chicago O'Hare International Airport to Piedmont Triad International Airport, train

    1. Fly from Chicago O'Hare International Airport (ORD) to Piedmont Triad International Airport (GSO)plane plane ORD - GSO
    2. Take the train from Greensboro to Durham Amtrak Stationtrain train
    6h 41m
    $138–576

Chicago to Duke University by bus and foot

Calendar14Weekly Services
Duration23h 16mAverage Duration
Ticket$140Cheapest Price
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Questions & Answers

Map of how to get from Chicago to Duke University.ExpandLaunch map view
  • Distance: 683 mi
  • Duration: 5h 56m

What companies run services between Chicago, IL, USA and Duke University, NC, USA?

You can take a bus from Chicago Bus Station to Duke University via Washington Union Station, Durham, Durham Station, and Flowers Dr at Duke Gardens in around 23h 16m.

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