Travel from Chicago to Charleston-SC-USA

Bus or fly from Chicago to Charleston?

Southwest Airlines and Delta fly from Chicago to Charleston 5 times a day. Alternatively, you can take a bus from Chicago to Charleston via Atlanta, GA, Savannah, GA, Charleston, SC, and Rivers Ave / Cosgrove Ave in around 24 h 34 min.

Travel Guides

Need to know: GreyhoundRome2rio’s guide on the bus operator has all the information you need
Want to know more about US trains?Rome2rio has everything you need to know about travelling with Amtrak

How to get from Chicago to Charleston

From Adams/Wabash subway to Chicago Midway airport, fly to Charleston airport, then Shuttle Bus to Charleston. 4 h 7 min $378. From Jackson-Blue subway to Chicago O'Hare airport, fly to Charleston airport, then Shuttle Bus to Charleston. 4 h 42 min $289. From Chicago, IL bus to Atlanta, GA, bus to Savannah, GA, bus to Charleston, SC, walk to Rivers Ave / Cosgrove Ave, then line 10 bus to Mary St / Meeting St. 24 h 34 min $129. From Chicago bus to Civic Center Station, subway to Atlanta, GA, bus to Charleston, SC, walk to Rivers Ave / Cosgrove Ave, then line 10 bus to Mary St / Meeting St. 26 h 47 min $126. From Chicago, IL bus to Atlanta, GA, bus to Charleston, SC, walk to Rivers Ave / Cosgrove Ave, then line 10 bus to Mary St / Meeting St. 27 h 7 min $127. From Chicago Union Station Amtrak train to Washington Union Station Amtrak, train to Yemassee Amtrak, then drive to Charleston. 30 h 7 min $388. From Chicago drive to Charleston. 15 h 16 min $109.
Close Print Itinerary
  1. Here are 7 options to get from
    Chicago to Charleston:

    1. Trip:
      1 Fly from Chicago Midway
      • One-Way approx: USD $197 - $629
      • Duration: 4 h 7 min
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      • Trip:
        1 Fly from Chicago Midway
        • One-Way approx: USD $197 - $629
        • Duration: 4 h 7 min
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    2. Trip:
      2 Fly from Chicago O'Hare
      • One-Way approx: USD $167 - $500
      • Duration: 4 h 42 min
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      • Trip:
        2 Fly from Chicago O'Hare
        • One-Way approx: USD $167 - $500
        • Duration: 4 h 42 min
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    3. Trip:
      3 Bus Greyhound USA
      • One-Way approx: USD $122 - $282
      • Duration: 24 h 34 min
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      • Trip:
        3 Bus Greyhound USA
        • One-Way approx: USD $122 - $282
        • Duration: 24 h 34 min
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    4. Trip:
      4 Bus Megabus
      • One-Way approx: USD $109 - $162
      • Duration: 26 h 47 min
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      • Trip:
        4 Bus Megabus
        • One-Way approx: USD $109 - $162
        • Duration: 26 h 47 min
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    5. Trip:
      5 Bus
      • One-Way approx: USD $117 - $252
      • Duration: 27 h 7 min
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      • Trip:
        5 Bus
        • One-Way approx: USD $117 - $252
        • Duration: 27 h 7 min
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    6. Trip:
      6 Train, drive
      • One-Way approx: USD $195 - $545
      • Duration: 30 h 7 min
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      • Trip:
        6 Train, drive
        • One-Way approx: USD $195 - $545
        • Duration: 30 h 7 min
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    7. Trip:
      7 Drive
      • One-Way approx: USD $85 - $130
      • Duration: 15 h 16 min
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      • Trip:
        7 Drive
        • One-Way approx: USD $85 - $130
        • Duration: 15 h 16 min
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