There are 8 ways to get from Chicago to Buffalo–Depew Station by plane, train, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Chicago Midway to Buffalo  •  4 h 38 min

  1. Fly from Chicago Midway (MDW) to Buffalo (BUF) MDW - BUF

$134 - $406

Cheapest option

Bus  •  13 h 8 min

  1. Take the bus from Chicago, Il to Cleveland, Oh 1604 / ...
  2. Take the bus from Cleveland, Oh to Buffalo, Ny 4178 / ...

$67 - $158

6 alternative options

Fly Chicago O'Hare to Buffalo  •  4 h 56 min

  1. Fly from Chicago O'Hare (ORD) to Buffalo (BUF) ORD - BUF

$124 - $377

Fly Chicago O'Hare to Rochester, train  •  5 h 47 min

  1. Fly from Chicago O'Hare (ORD) to Rochester (ROC) ORD - ROC
  2. Take the train from Rochester Amtrak to Buffalo Depew Station Amtrak

$168 - $406

Fly Chicago O'Hare to Erie, train  •  5 h 50 min

  1. Fly from Chicago O'Hare (ORD) to Erie (ERI) ORD - ERI
  2. Take the train from Erie Amtrak to Buffalo Depew Station Amtrak

$197 - $852

Train  •  10 h 16 min

  1. Take the train from Chicago Union Station Amtrak to Buffalo Depew Station Amtrak Lake Shore Limited

$75 - $220

Bus, train  •  17 h 43 min

  1. Take the bus from Chicago, IL to Toronto - Royal York Hotel 5500 / ...
  2. Take the train from Toronto to Buffalo VIA Rail

$76 - $202

Drive  •  8 h 59 min

  1. Drive from Chicago to Buffalo–Depew Station 539 miles

$50 - $80

Questions & Answers

The cheapest way to get from Chicago to Buffalo–Depew Station is to drive which costs $50 - $80 and takes 8 h 59 min.

More details

The quickest way to get from Chicago to Buffalo–Depew Station is to fly which costs $130 - $410 and takes 4 h 38 min.

More details

The distance between Chicago and Buffalo–Depew Station is 462 miles. The road distance is 539 miles.

Get driving directions

It takes approximately 4 h 38 min to get from Chicago to Buffalo–Depew Station, including transfers.

More details

No, there is no direct bus from Chicago to Buffalo–Depew Station. However, there are services departing from Chicago, Il and arriving at Walden Ave & 2929 Walden via Cleveland, Oh, Ellicott St & North Division St and Galleria Drway & Green Parking Entrance. The journey, including transfers, takes approximately 13 h 8 min.

More details

Yes, there is a direct train departing from Chicago Union Station Amtrak station and arriving at Buffalo Depew Station Amtrak station. Services depart twice daily, and operate every day. The journey takes approximately 10 h 16 min.

More details

What companies run services between Chicago, IL, USA and Buffalo–Depew Station, NY, USA?

Southwest Airlines and Delta fly from Chicago to Buffalo–Depew Station 5 times a day. Alternatively, Amtrak operates a train from Chicago to Buffalo–Depew Station twice daily. Tickets cost $75 - $220 and the journey takes 10 h 16 min.

Airlines
United Airlines
Website
united.com
Flights from Chicago O'Hare to Buffalo
Ave. Duration
1 h 37 min
When
Every day
Estimated price
$140 - $750
Flights from Chicago O'Hare to Buffalo via Washington Dulles
Ave. Duration
3 h 57 min
When
Every day
Estimated price
$140 - $750
Flights from Chicago O'Hare to Rochester
Ave. Duration
1 h 42 min
When
Every day
Estimated price
$180 - $700
Flights from Chicago O'Hare to Erie
Ave. Duration
1 h 31 min
When
Every day
Estimated price
$160 - $800
Southwest Airlines
Website
southwest.com
Flights from Chicago Midway to Buffalo
Ave. Duration
1 h 26 min
When
Every day
Estimated price
$160 - $750
Delta
Website
delta.com
Flights from Chicago Midway to Buffalo via Detroit
Ave. Duration
3 h 41 min
When
Every day
Estimated price
$130 - $800
Flights from Chicago O'Hare to Buffalo via Detroit
Ave. Duration
3 h 39 min
When
Every day
Estimated price
$130 - $800
Flights from Chicago O'Hare to Rochester via Detroit
Ave. Duration
3 h 51 min
When
Every day
Estimated price
$160 - $800
Flights from Chicago O'Hare to Erie via Detroit
Ave. Duration
3 h 31 min
When
Every day
Estimated price
$140 - $750
American Airlines
Website
aa.com
Flights from Chicago O'Hare to Buffalo
Ave. Duration
1 h 31 min
When
Every day
Estimated price
$120 - $650
Flights from Chicago O'Hare to Rochester
Ave. Duration
1 h 38 min
When
Every day
Estimated price
$160 - $700
Train operators
Amtrak
Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Rochester Amtrak to Buffalo Depew Station Amtrak
Ave. Duration
46 min
Frequency
Every 4 hours
Estimated price
$25 - $50
Website
amtrak.com
Coach Seat
$25 - $40
Flexi Coach Seat
$45 - $65
Business Coach Seat
$35 - $50
Room
$140 - $200
Train from Erie Amtrak to Buffalo Depew Station Amtrak
Ave. Duration
1 h 26 min
Frequency
Twice daily
Estimated price
$29 - $65
Website
amtrak.com
Coach Seat
$29 - $45
Flexi Coach Seat
$50 - $75
Business Coach Seat
$40 - $65
Room
$150 - $220
Train from Chicago Union Station Amtrak to Buffalo Depew Station Amtrak
Ave. Duration
10 h 16 min
Frequency
Twice daily
Estimated price
$75 - $220
Website
amtrak.com
Coach Seat
$75 - $120
Flexi Coach Seat
$140 - $200
Business Coach Seat
$150 - $220
Room
$330 - $460
VIA Rail
Phone
+1 1 888 842-7245
Website
viarail.ca
Train from Rochester to Buffalo
Ave. Duration
1 h 4 min
Frequency
Every 3 hours
Estimated price
$24 - $70
Website
viarail.ca
Escape
$24 - $35
Economy
$30 - $45
Economy Plus
$45 - $70
Business
$40 - $60
Business Plus/Sleeper
$75 - $110
Train from Toronto to Buffalo
Ave. Duration
4 h 9 min
Frequency
Every 3 hours
Estimated price
$29 - $90
Website
viarail.ca
Escape
$29 - $45
Economy
$40 - $55
Economy Plus
$60 - $90
Business
$55 - $80
Business Plus/Sleeper
$100 - $150
Bus operators
Greyhound USA
Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Chicago, Il to Cleveland, Oh
Ave. Duration
7 h 15 min
Frequency
Hourly
Estimated price
$35 - $95
Website
greyhound.com
Economy
$35 - $65
Flexible
$70 - $95
Bus from Cleveland, Oh to Buffalo, Ny
Ave. Duration
3 h 45 min
Frequency
Every 30 minutes
Estimated price
$24 - $60
Website
greyhound.com
Economy
$24 - $40
Flexible
$45 - $60
Greyhound Canada
Phone
+1 1-800-661-8747
Email
Canada.info@greyhound.ca
Website
greyhound.ca
Bus from Chicago, IL to Toronto - Royal York Hotel
Ave. Duration
12 h 34 min
Frequency
Twice daily
Estimated price
$45 - $120
Website
Greyhound.ca
Advanced Purchase
$45 - $70
Online Fare
$60 - $90
Standard Fare
$75 - $120
Refundable
$85 - $130

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