There are 7 ways to get from Chicago Loop to St. Louis by train (Amtrak), bus (Flixbus), car, plane, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train (Amtrak)
best- Take the train from Chicago Union Station to St. LouisLincoln Service / ...
4h 46m$30–120Bus (Flixbus)
- Take the bus from Chicago Bus Station to St Louis Bus StationFlixBus 2510 / ...
6h$35–85Drive 296.1 mi
- Drive from Chicago Loop to St. Louis296.1 mi
4h 55m$54–78Fly Chicago Midway International Airport to Lambert–St. Louis International Airport
- Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)MDW - STL
3h 35m$76–558Fly Chicago O'Hare International Airport to Lambert–St. Louis International Airport
- Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)ORD - STL
3h 46m$136–488Train to General Mitchell International Airport, fly to Lambert–St. Louis International Airport
- Take the train from Chicago Union Station to Milwaukee
- Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)MKE - STL
5h 6m$227–619Fly Chicago O'Hare International Airport to Decatur Airport, drive
- Fly from Chicago O'Hare International Airport (ORD) to Decatur Airport (DEC)ORD - DEC
- Drive from Decatur Airport (DEC) to St. Louis
5h 13m$60–300
Chicago Loop to St. Louis by train (Amtrak)
Questions & Answers
The cheapest way to get from Chicago Loop to St. Louis is to bus which costs $35 - $85 and takes 6h.
The fastest way to get from Chicago Loop to St. Louis is to fly which takes 3h 35m and costs $75 - $600.
Yes, there is a direct bus departing from Chicago Bus Station station and arriving at St Louis Bus Station station. Services depart twice daily, and operate every day. The journey takes approximately 6h.
Yes, there is a direct train departing from Chicago Union Station station and arriving at St. Louis. Services depart five times a day, and operate every day. The journey takes approximately 4h 46m.
The distance between Chicago Loop and St. Louis is 282 miles. The road distance is 297.8 miles.
The best way to get from Chicago Loop to St. Louis without a car is to train which takes 4h 46m and costs $30 - $120.
The train from Chicago Union Station to St. Louis takes 4h 46m including transfers and departs five times a day.
Chicago Loop to St. Louis bus services, operated by Flixbus USA, depart from Chicago Bus Station.
Chicago Loop to St. Louis train services, operated by Amtrak, depart from Chicago Union Station.
The best way to get from Chicago Loop to St. Louis is to train which takes 4h 46m and costs $30 - $120. Alternatively, you can bus, which costs $35 - $85 and takes 6h, you could also fly, which costs $75 - $600 and takes 3h 35m.
What companies run services between Chicago Loop, IL, USA and St. Louis, MO, USA?
Amtrak operates a train from Chicago Union Station to St. Louis 5 times a day. Tickets cost $30–120 and the journey takes 4h 46m. Alternatively, Flixbus USA operates a bus from Chicago Bus Station to St Louis Bus Station twice daily. Tickets cost $35–85 and the journey takes 6h.
- Website
- southwest.com
Flights from Chicago Midway International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 13m
- When
- Every day
- Estimated price
- $70–550
Flights from General Mitchell International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 21m
- When
- Every day
- Estimated price
- $110–750
- Website
- united.com
Flights from Chicago O'Hare International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 27m
- When
- Every day
- Estimated price
- $55–410
Flights from General Mitchell International Airport to Lambert–St. Louis International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 3h 31m
- When
- Every day
- Estimated price
- $110–750
Flights from Chicago O'Hare International Airport to Decatur Airport
- Ave. Duration
- 1h 2m
- When
- Every day
- Estimated price
- $35–260
- Website
- aa.com
Flights from Chicago O'Hare International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 27m
- When
- Every day
- Estimated price
- $55–410
Flights from General Mitchell International Airport to Lambert–St. Louis International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 3h 37m
- When
- Tuesday and Wednesday
- Estimated price
- $110–750
- Website
- gojetairlines.com
Flights from Chicago O'Hare International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 34m
- When
- Every day
- Estimated price
- $55–410
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Chicago Union Station to St. Louis
- Ave. Duration
- 4h 46m
- Frequency
- 5 times a day
- Estimated price
- $30–120
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to Milwaukee
- Ave. Duration
- 1h 29m
- Frequency
- Every 4 hours
- Estimated price
- $22–40
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Chicago Bus Station to St Louis Bus Station
- Ave. Duration
- 6h
- Frequency
- Twice daily
- Estimated price
- $35–85
- Schedules at
- flixbus.com
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More Questions & Answers
Chicago Loop to St. Louis bus services, operated by Flixbus USA, arrive at St Louis Bus Station.
Chicago Loop to St. Louis train services, operated by Amtrak, arrive at St. Louis station.
Yes, the driving distance between Chicago Loop to St. Louis is 298 miles. It takes approximately 4h 55m to drive from Chicago Loop to St. Louis.
Book your Chicago Loop to St. Louis train tickets online with Omio.
Book your Chicago Loop to St. Louis bus tickets online with Omio and FlixBus.
There are 427+ hotels available in St. Louis.