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How to get fromChicago Loop to Sikestonby plane, car, bus, train, or taxi

Find Transport to Sikeston

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There are 7 ways to get from Chicago Loop to Sikeston by plane, car, bus, train, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Barkley Regional Airport, drive

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Barkley Regional Airport (PAH)plane plane ORD - PAH
    2. Drive from Barkley Regional Airport (PAH) to Sikestoncar car
    4h 24m
    $58–310

  2. Bus

    1. Take the bus from Tornado Bus Co - Chicago to Flying J - Matthewsbus bus Milwaukee
    9h 12m
    $114–148

  3. Train, drive (Amtrak)

    1. Take the train from Chicago Union Station to Fulton Amtrak Stationtrain train City of New Orleans
    2. Drive from Fulton Amtrak Station to Sikestoncar car
    9h 16m
    $121–258

  4. Drive  395.6 mi

    1. Drive from Chicago Loop to Sikestoncar car 395.6 mi
    6h 32m
    $73–105

  5. Fly Chicago O'Hare International Airport to Williamson County Regional Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Williamson County Regional Airport (MWA)plane plane ORD - MWA
    2. Take the bus from Marathon Gas Station - Marion to Flying J - Matthewsbus bus
    5h 53m
    $138–306

  6. Fly Chicago Midway International Airport to Lambert–St. Louis International Airport, bus, taxi

    1. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    3. Take the taxi from Cape Girardeau to Sikestontaxi taxi
    7h 14m
    $182–658

  7. Fly Chicago O'Hare International Airport to Lambert–St. Louis International Airport, bus, taxi

    1. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    3. Take the taxi from Cape Girardeau to Sikestontaxi taxi
    7h 28m
    $382–858

Chicago O'Hare International Airport (ORD) to Barkley Regional Airport (PAH) flights

Calendar7Weekly Planes
Duration1h 30mAverage Duration
Ticket$45Cheapest Price
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Questions & Answers

Map of how to get from Chicago Loop to Sikeston.ExpandLaunch map view
  • Distance: 415.1 mi
  • Duration: 4h 24m

What companies run services between Chicago Loop, IL, USA and Sikeston, MO, USA?

Tornado Bus Company operates a bus from Tornado Bus Co - Chicago to Flying J - Matthews once daily. Tickets cost $80–100 and the journey takes 7h 24m.

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