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How to get fromChicago Loop to San Diegoby plane, train (Amtrak), bus (Flixbus, Greyhound, Amtrak), car or train

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There are 6 ways to get from Chicago Loop to San Diego by plane, train (Amtrak), bus (Flixbus, Greyhound, Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Chicago O'Hare International Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to San Diego International Airport (SAN)planeORD - SAN
    6h 32m
    $104–350

  2. Train (Amtrak)

    1. Take the train from Chicago Union Station to Fullerton Amtrak StationtrainSouthwest Chief
    2. Take the train from Fullerton Amtrak Station to San DiegotrainPacific Surfliner
    46h 7m
    $190–393

  3. Bus

    1. Take the bus from Chicago Bus Station to St Louis Bus Stationbus
    2. Take the bus from St Louis Bus Station to Los Angeles Union Stationbus
    3. Take the bus from Los Angeles to San Diegobus
    2d 2h

  4. Drive 2,075.1 mi

    1. Drive from Chicago Loop to San Diegocar2,075.1 mi
    32h 25m
    $379–547

  5. Fly from Chicago Midway International Airport

    1. Fly from Chicago Midway International Airport (MDW) to San Diego International Airport (SAN)planeMDW - SAN
    6h 28m
    $164–710

  6. Train to General Mitchell International Airport, fly

    1. Take the train from Chicago Union Station to Milwaukeetrain
    2. Fly from General Mitchell International Airport (MKE) to San Diego International Airport (SAN)planeMKE - SAN
    7h 49m
    $266–1,223

Chicago Loop to San Diego by train (Amtrak)

Calendar13Weekly Trains
Duration46h 7mAverage Duration
Ticket$190Cheapest Price
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Questions & Answers

What companies run services between Chicago Loop, IL, USA and San Diego, CA, USA?

American Airlines, Alaska Airlines, Inc., and two other airlines fly from Chicago O'Hare International Airport (ORD) to San Diego International Airport (SAN) hourly. Alternatively, you can take a train from Chicago Union Station to San Diego via Fullerton Amtrak Station in around 46h 7m.

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