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How to get fromChicago Loop to Saint Charlesby train (Amtrak), bus (Flixbus), car, plane, bus, subway or train

Find Transport to Saint Charles

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There are 6 ways to get from Chicago Loop to Saint Charles by train (Amtrak), bus (Flixbus), car, plane, bus, subway, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    6h 11m
    $85–176

  2. Bus (Flixbus)

    cheapest
    1. Take the bus from Chicago Bus Station to St Louis Bus Stationbus bus FlixBus N2521 / ...
    8h 8m
    $44–73

  3. Drive 310 mi

    1. Drive from Chicago Loop to Saint Charlescar car 310 mi
    5h 15m
    $57–82

  4. Fly from Chicago O'Hare International Airport, line 34 bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    2. Take the bus from North Hanley Transit Center to 4375 Rider Trail North Sbbus bus
    4h 8m
    $256–499

  5. Subway to Chicago Midway International Airport, fly

    1. Take the subway from Washington/Wells to Midwaysubway subway
    2. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    3h 59m
    $106–709

  6. Train to General Mitchell International Airport, fly

    1. Take the train from Chicago Union Station to Milwaukeetrain train
    2. Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane plane MKE - STL
    5h 31m
    $180–1,170

Chicago Loop to Saint Charles by train and bus (Amtrak)

Calendar38Weekly Services
Duration6h 11mAverage Duration
Ticket$85Cheapest Price
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Questions & Answers

What companies run services between Chicago Loop, IL, USA and Saint Charles, MO, USA?

Amtrak operates a train from Chicago Union Station to St. Louis 5 times a day. Tickets cost $80–180 and the journey takes 4h 46m. Alternatively, Flixbus USA operates a bus from Chicago Bus Station to St Louis Bus Station 3 times a day. Tickets cost $40–75 and the journey takes 6h 10m.

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