There are 7 ways to get from Chicago, IL to St. Louis by train (Amtrak), bus (Flixbus), car, plane, subway, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train (Amtrak)
best- Take the train from Chicago Union Station to St. Louistrain Lincoln Service / ...
4h 55m$35–220Bus (Flixbus)
- Take the bus from Chicago Bus Station to St Louis Bus Stationbus FlixBus N2521 / ...
6h 10m$35–70Drive 294.9 mi
- Drive from Chicago, IL to St. Louiscar 294.9 mi
4h 57m$54–78Fly Chicago O'Hare International Airport to Lambert–St. Louis International Airport
- Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane ORD - STL
4h 6m$206–498Subway to Chicago Midway International Airport, fly to Lambert–St. Louis International Airport
- Take the subway from Quincy to Midwaysubway
- Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane MDW - STL
3h 51m$86–558Train to General Mitchell International Airport, fly to Lambert–St. Louis International Airport
- Take the train from Chicago Union Station to Milwaukeetrain
- Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane MKE - STL
5h 15m$147–921Fly Chicago O'Hare International Airport to Decatur Airport, drive
- Fly from Chicago O'Hare International Airport (ORD) to Decatur Airport (DEC)plane ORD - DEC
- Drive from Decatur Airport (DEC) to St. Louiscar
5h 39m$60–290
Chicago, IL to St. Louis by foot and train (Amtrak)
Questions & Answers
The cheapest way to get from Chicago, IL to St. Louis is to bus which costs $35 - $70 and takes 6h 10m.
The fastest way to get from Chicago, IL to St. Louis is to subway and fly which takes 3h 51m and costs $85 - $600.
Yes, there is a direct bus departing from Chicago Bus Station station and arriving at St Louis Bus Station station. Services depart three times a day, and operate every day. The journey takes approximately 6h 10m.
Yes, there is a direct train departing from Chicago Union Station station and arriving at St. Louis. Services depart five times a day, and operate every day. The journey takes approximately 4h 46m.
The distance between Chicago, IL and St. Louis is 283 miles. The road distance is 296.6 miles.
The best way to get from Chicago, IL to St. Louis without a car is to train which takes 4h 55m and costs $35 - $220.
The train from Chicago Union Station to St. Louis takes 4h 46m including transfers and departs five times a day.
Chicago, IL to St. Louis bus services, operated by Flixbus USA, depart from Chicago Bus Station.
Chicago, IL to St. Louis train services, operated by Amtrak, depart from Chicago Union Station.
The best way to get from Chicago, IL to St. Louis is to train which takes 4h 55m and costs $35 - $220. Alternatively, you can bus, which costs $35 - $70 and takes 6h 10m, you could also fly, which costs $200 - $500 and takes 4h 6m.
What companies run services between Chicago, IL, USA and St. Louis, MO, USA?
Amtrak operates a train from Chicago Union Station to St. Louis 5 times a day. Tickets cost $35–220 and the journey takes 4h 46m. Alternatively, Flixbus USA operates a bus from Chicago Bus Station to St Louis Bus Station 3 times a day. Tickets cost $35–70 and the journey takes 6h 10m.
- Website
- southwest.com
Flights from Chicago Midway International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 17m
- When
- Every day
- Estimated price
- $80–550
Flights from General Mitchell International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 31m
- When
- Every day
- Estimated price
- $120–800
- Website
- united.com
Flights from Chicago O'Hare International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 31m
- When
- Every day
- Estimated price
- $65–420
Flights from Chicago O'Hare International Airport to Decatur Airport
- Ave. Duration
- 1h 14m
- When
- Every day
- Estimated price
- $35–250
- Website
- aa.com
Flights from Chicago O'Hare International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 26m
- When
- Every day
- Estimated price
- $65–420
Flights from General Mitchell International Airport to Lambert–St. Louis International Airport via Chicago O'Hare International Airport
- Ave. Duration
- 3h 36m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $120–800
- Website
- gojetairlines.com
Flights from Chicago O'Hare International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 28m
- When
- Every day
- Estimated price
- $65–420
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Chicago Union Station to St. Louis
- Ave. Duration
- 4h 46m
- Frequency
- 5 times a day
- Estimated price
- $35–220
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to Milwaukee
- Ave. Duration
- 1h 29m
- Frequency
- Every 4 hours
- Estimated price
- $22–40
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 888-968-7282
- Website
- transitchicago.com
Subway from Quincy to Midway
- Ave. Duration
- 32 min
- Frequency
- Every 15 minutes
- Estimated price
- $2–5
- Website
- https://www.transitchicago.com
- Schedules at
- https://www.transitchicago.com/schedules/
- Adult
- $2–5
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Chicago Bus Station to St Louis Bus Station
- Ave. Duration
- 6h 10m
- Frequency
- 3 times a day
- Estimated price
- $35–70
- Schedules at
- flixbus.com
Want to know more about travelling around United States
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More Questions & Answers
Chicago, IL to St. Louis bus services, operated by Flixbus USA, arrive at St Louis Bus Station.
Chicago, IL to St. Louis train services, operated by Amtrak, arrive at St. Louis station.
Yes, the driving distance between Chicago, IL to St. Louis is 297 miles. It takes approximately 4h 57m to drive from Chicago, IL to St. Louis.
Book your Chicago, IL to St. Louis train tickets online with Omio.
Book your Chicago, IL to St. Louis bus tickets online with Omio and FlixBus.
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