There are 6 ways to get from Chicago Bus Station to St. Louis by train (Amtrak), bus (Flixbus), car, plane, subway, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train (Amtrak)
best- Take the train from Chicago Union Station to St. Louistrain Lincoln Service / ...
4h 55m$75–180Bus (Flixbus)
cheapest- Take the bus from Chicago Bus Station to St Louis Bus Stationbus FlixBus 2510 / ...
5h 55m$40–75Drive 294.9 mi
- Drive from Chicago Bus Station to St. Louiscar 294.9 mi
4h 57m$54–78Fly from Chicago O'Hare International Airport
- Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane ORD - STL
3h 59m$266–558Subway to Chicago Midway International Airport, fly
- Take the subway from Quincy to Midwaysubway
- Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane MDW - STL
3h 51m$100–708Train to General Mitchell International Airport, fly
- Take the train from Chicago Union Station to Milwaukeetrain
- Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane MKE - STL
5h 15m$179–1,169
Chicago Bus Station to St. Louis by foot and train (Amtrak)
Questions & Answers
The cheapest way to get from Chicago Bus Station to St. Louis is to bus which costs $40 - $75 and takes 5h 55m.
The fastest way to get from Chicago Bus Station to St. Louis is to subway and fly which takes 3h 51m and costs $100 - $750.
Yes, there is a direct bus departing from Chicago Bus Station station and arriving at St Louis Bus Station station. Services depart three times a day, and operate every day. The journey takes approximately 5h 55m.
Yes, there is a direct train departing from Chicago Union Station station and arriving at St. Louis. Services depart five times a day, and operate every day. The journey takes approximately 4h 46m.
The distance between Chicago Bus Station and St. Louis is 283 miles. The road distance is 296.6 miles.
The best way to get from Chicago Bus Station to St. Louis without a car is to train which takes 4h 55m and costs $75 - $180.
The train from Chicago Union Station to St. Louis takes 4h 46m including transfers and departs five times a day.
Chicago Bus Station to St. Louis bus services, operated by Flixbus USA, depart from Chicago Bus Station.
Chicago Bus Station to St. Louis train services, operated by Amtrak, depart from Chicago Union Station.
The best way to get from Chicago Bus Station to St. Louis is to train which takes 4h 55m and costs $75 - $180. Alternatively, you can bus, which costs $40 - $75 and takes 5h 55m, you could also fly, which costs $260 - $600 and takes 3h 59m.
What companies run services between Chicago Bus Station, IL, USA and St. Louis, MO, USA?
Amtrak operates a train from Chicago Union Station to St. Louis 5 times a day. Tickets cost $75–180 and the journey takes 4h 46m. Alternatively, Flixbus USA operates a bus from Chicago Bus Station to St Louis Bus Station 3 times a day. Tickets cost $40–75 and the journey takes 5h 55m.
- Website
- united.com
Flights from Chicago O'Hare International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 29m
- When
- Every day
- Estimated price
- $70–500
- Website
- southwest.com
Flights from Chicago Midway International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 14m
- When
- Every day
- Estimated price
- $95–700
Flights from General Mitchell International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- $150–1,100
Flights from General Mitchell International Airport to Lambert–St. Louis International Airport via Chicago Midway International Airport
- Ave. Duration
- 3h 32m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $160–1,100
- Website
- aa.com
Flights from Chicago O'Hare International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 24m
- When
- Every day
- Estimated price
- $70–500
- Website
- gojetairlines.com
Flights from Chicago O'Hare International Airport to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 31m
- When
- Every day
- Estimated price
- $70–500
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Chicago Union Station to St. Louis
- Ave. Duration
- 4h 46m
- Frequency
- 5 times a day
- Estimated price
- $75–180
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to Milwaukee
- Ave. Duration
- 1h 29m
- Frequency
- Every 4 hours
- Estimated price
- $23–55
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 888-968-7282
- Website
- transitchicago.com
Subway from Quincy to Midway
- Ave. Duration
- 32 min
- Frequency
- Every 15 minutes
- Estimated price
- $2–5
- Website
- https://www.transitchicago.com
- Schedules at
- https://www.transitchicago.com/schedules/
- Adult
- $2–5
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Chicago Bus Station to St Louis Bus Station
- Ave. Duration
- 5h 55m
- Frequency
- 3 times a day
- Estimated price
- $40–75
- Schedules at
- flixbus.com
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More Questions & Answers
Chicago Bus Station to St. Louis bus services, operated by Flixbus USA, arrive at St Louis Bus Station.
Chicago Bus Station to St. Louis train services, operated by Amtrak, arrive at St. Louis station.
Yes, the driving distance between Chicago Bus Station to St. Louis is 297 miles. It takes approximately 4h 57m to drive from Chicago Bus Station to St. Louis.
Book your Chicago Bus Station to St. Louis train tickets online with Omio.
Book your Chicago Bus Station to St. Louis bus tickets online with Omio and FlixBus.
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