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How to get fromChicago, IL to Buffaloby plane, bus (Greyhound), train (Amtrak), car, subway, bus or bus (Greyhound, Flixbus)

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There are 8 ways to get from Chicago, IL to Buffalo by plane, bus (Greyhound), train (Amtrak), car, subway, bus, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Buffalo Niagara International Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Buffalo Niagara International Airport (BUF)planeORD - BUF
    4h 48m
    $156–985

  2. Bus via Cleveland

    cheapest
    1. Take the bus from Chicago Bus Station to Cleveland Bus StationbusGreyhound US0164
    2. Take the bus from Cleveland, OH to Buffalo, NYbusCinncinati,OH-Buffalo
    11h 20m
    $52–145

  3. Train (Amtrak)

    1. Take the train from Chicago Union Station to Buffalo Depew StationtrainLake Shore Limited
    11h 53m
    $65–277

  4. Drive 532.4 mi

    1. Drive from Chicago, IL to Buffalocar532.4 mi
    8h 56m
    $98–141

  5. Subway to Chicago Midway International Airport, fly to Buffalo Niagara International Airport

    1. Take the subway from Quincy to Midwaysubway
    2. Fly from Chicago Midway International Airport (MDW) to Buffalo Niagara International Airport (BUF)planeMDW - BUF
    4h 38m
    $196–1,185

  6. Fly Chicago O'Hare International Airport to Rochester, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Rochester (ROC)planeORD - ROC
    2. Take the bus from Rochester, NY to Buffalo, NYbus
    6h 56m
    $136–630

  7. Fly Chicago Midway International Airport to Rochester, bus

    1. Fly from Chicago Midway International Airport (MDW) to Rochester (ROC)planeMDW - ROC
    2. Take the bus from Rochester, NY to Buffalo, NYbus
    6h 48m
    $126–740

  8. Bus

    1. Take the bus from Chicago Bus Station to Detroit Bus Stationbus
    2. Take the bus from Detroit Bus Station to Torontobus
    3. Take the bus from Toronto to Buffalobus
    17h 15m
    $89–249

Chicago, IL to Buffalo by bus

Calendar14Weekly Buses
Duration11h 20mAverage Duration
Ticket$52Cheapest Price
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Questions & Answers

What companies run services between Chicago, IL, USA and Buffalo, NY, USA?

American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Buffalo Niagara International Airport (BUF) every 2 hours. Alternatively, you can take a bus from Chicago Bus Station to Buffalo, NY via Cleveland Bus Station and Cleveland, OH in around 11h 20m.

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