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How to get fromCharlotte to St. Louisby plane, bus (Flixbus, Greyhound), train (Amtrak), car or bus (Greyhound)

Find Transport to St. Louis

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There are 5 ways to get from Charlotte to St. Louis by plane, bus (Flixbus, Greyhound), train (Amtrak), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL)plane plane CLT - STL
    4h 14m
    $285–415

  2. Bus

    cheapest
    1. Take the bus from Charlotte Bus Station to Atlanta Bus Stationbus bus FlixBus N2471 / ...
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    15h 50m
    $94–182

  3. Train (Amtrak)

    1. Take the train from Charlotte Amtrak Station to Raleigh Union Stationtrain train
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    34h 39m
    $339–788

  4. Drive 709 mi

    1. Drive from Charlotte to St. Louiscar car 709 mi
    12h 5m
    $130–187

  5. Bus via Columbus

    1. Take the bus from Charlotte Bus Station to Columbusbus bus Greyhound US0140
    2. Take the bus from Columbus to St Louis Bus Stationbus bus Greyhound US0421
    20h 10m
    $111–226

Charlotte to St. Louis by bus

Calendar7Weekly Buses
Duration15h 50mAverage Duration
Ticket$94Cheapest Price
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Questions & Answers

What companies run services between Charlotte, NC, USA and St. Louis, MO, USA?

American Airlines, Southwest Airlines, and Delta fly from Charlotte Douglas International Airport (CLT) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, you can take a bus from Charlotte Bus Station to St Louis Bus Station via Atlanta Bus Station in around 15h 50m.

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